PAK4
Summary: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| p21 (RAC1) activated kinase 4 | MIM:605451 | Ensembl:ENSG00000130669 | HGNC:HGNC:16059 | PA32920 | 19q13.2 |
GO terms in PAK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IMP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0048365 | Rac GTPase binding |
| MF | HDA | GO:0098641 | cadherin binding involved in cell-cell adhesion |
| BP | TAS | GO:0001558 | regulation of cell growth |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007010 | cytoskeleton organization |
| BP | IEA | GO:0007049 | cell cycle |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007266 | Rho protein signal transduction |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IBA | GO:0016477 | cell migration |
| BP | TAS | GO:0016477 | cell migration |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0030036 | actin cytoskeleton organization |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IBA | GO:0043408 | regulation of MAPK cascade |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | IEA | GO:0060996 | dendritic spine development |
| BP | IEA | GO:0071407 | cellular response to organic cyclic compound |
| BP | IEA | GO:0098609 | cell-cell adhesion |
| BP | IMP | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005794 | Golgi apparatus |
| CC | HDA | GO:0005913 | cell-cell adherens junction |
| CC | HDA | GO:0005925 | focal adhesion |
Gene expression in normal tissue: PAK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PAK4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP673 | ErbB Signaling Pathway |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | fgf_pathway | FGF signaling pathway |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-428540 | Activation of RAC1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD511 | CHEMBL399379 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PAK4
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