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iGMDRD424

Canonical SMILES: CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C

InChI: InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)

InChI Key: NHHQJBCNYHBUSI-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Tamatinib	CHEMBL475251	11213600	DB07159	Alone	Small Molecule

Drug Targets:

SYK (P43405)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3725	JUN	2
5027	P2RX7	3
10903	MTMR11	2
7837	PXDN	2
79054	TRPM8	1
1464	CSPG4	3
23085	ERC1	1
6491	STIL	3
21	ABCA3	9
132	ADK	2
6774	STAT3	2
6195	RPS6KA1	3
7161	TP73	3
7750	ZMYM2	2
2986	GUCY2F	2
5546	PRCC	2
23513	SCRIB	2
7171	TPM4	6
4303	FOXO4	2
57679	ALS2	3
3708	ITPR1	3
1969	EPHA2	3
7272	TTK	5
1138	CHRNA5	3
3757	KCNH2	2
4750	NEK1	3
55215	FANCI	6
8289	ARID1A	2
80070	ADAMTS20	4
8573	CASK	3
5593	PRKG2	3
79092	CARD14	3
53616	ADAM22	1
1263	PLK3	1
6597	SMARCA4	2
150209	AIFM3	3
3551	IKBKB	1
4036	LRP2	3
11160	ERLIN2	1
7444	VRK2	3
56776	FMN2	3
10892	MALT1	3
23235	SIK2	6
1607	DGKB	1
3066	HDAC2	2
22853	LMTK2	5
7253	TSHR	8
27	ABL2	2
8749	ADAM18	3
3841	KPNA5	2
55534	MAML3	3
1404	HAPLN1	3
9816	URB2	9
2249	FGF4	1
80122	MAP3K19	3
1387	CREBBP	2
9232	PTTG1	4
5467	PPARD	3
2313	FLI1	3
10013	HDAC6	2
31	ACACA	2
10178	TENM1	1
57472	CNOT6	1
5966	REL	1
29998	BICRA	1
1111	CHEK1	1
2977	GUCY1A2	2
3456	IFNB1	1
9024	BRSK2	2
139378	ADGRG4	3
89910	UBE3B	2
10295	BCKDK	4
8784	TNFRSF18	3
5664	PSEN2	1
637	BID	2
2115	ETV1	3
5081	PAX7	1
5607	MAP2K5	5
256646	NUTM1	3
122011	CSNK1A1L	2
57787	MARK4	5
169436	STKLD1	3
64083	GOLPH3	1
22806	IKZF3	3
2242	FES	3
22984	PDCD11	2
80351	TNKS2	3
6091	ROBO1	3
116986	AGAP2	2
114548	NLRP3	6
5984	RFC4	3
10298	PAK4	2
2736	GLI2	2
695	BTK	5
51804	SIX4	3
83931	STK40	2
1143	CHRNB4	1
23405	DICER1	2
1277	COL1A1	2
375449	MAST4	1
4752	NEK3	3
6850	SYK	1
287015	TRIM42	2
8643	PTCH2	1
1456	CSNK1G3	2
783	CACNB2	2
9131	AIFM1	3
4140	MARK3	2
6416	MAP2K4	1
29760	BLNK	1
8714	ABCC3	3
158056	MAMDC4	2
50488	MINK1	3
6464	SHC1	3
8515	ITGA10	3
2778	GNAS	2
2580	GAK	3
1009	CDH11	2
139285	AMER1	1
83903	HASPIN	4
53942	CNTN5	2
5924	RASGRF2	3
84433	CARD11	2
4058	LTK	1
54986	ULK4	2
1496	CTNNA2	3
7010	TEK	1
91461	PKDCC	3
2066	ERBB4	4
839	CASP6	3
5863	RGL2	5
1029	CDKN2A	6
7184	HSP90B1	1
9794	MAML1	2
23048	FNBP1	2
2868	GRK4	6
3236	HOXD10	3
11143	KAT7	3
3932	LCK	1
58508	KMT2C	1
7157	TP53	1
2099	ESR1	2
7704	ZBTB16	3
6794	STK11	2
2322	FLT3	2
57194	ATP10A	1
8218	CLTCL1	3
5910	RAP1GDS1	3
3791	KDR	3
836	CASP3	1
2263	FGFR2	1
225689	MAPK15	3
9639	ARHGEF10	2
9967	THRAP3	2
105	ADARB2	1
8874	ARHGEF7	2
1102	RCBTB2	1
23043	TNIK	6
55437	STRADB	1
369	ARAF	2
8660	IRS2	3
57188	ADAMTSL3	3
65125	WNK1	2
136332	LRGUK	3
4436	MSH2	2
50945	TBX22	2
676	BRDT	1
984	CDK11B	3
4437	MSH3	3
8923202	COX2	1
2071	ERCC3	5
2175	FANCA	1
23469	PHF3	5
6654	SOS1	3
672	BRCA1	1
2668	GDNF	1
2737	GLI3	1
4139	MARK1	4
10733	PLK4	2
5727	PTCH1	9
546	ATRX	4
51366	UBR5	3
3426	CFI	2
5297	PI4KA	2
6134	RPL10	1
5069	PAPPA	6
501	ALDH7A1	3
10926	DBF4	2
30827	CXXC1	3
57144	PAK5	2
3239	HOXD13	5
84823	LMNB2	3
5290	PIK3CA	3
3720	JARID2	1
1000	CDH2	9
4293	MAP3K9	5
26524	LATS2	2
90	ACVR1	2
10565	ARFGEF1	3
64919	BCL11B	3
5530	PPP3CA	3
7075	TIE1	2
1956	EGFR	3
4609	MYC	3
64333	ARHGAP9	3
64750	SMURF2	2
90956	ADCK2	3
91	ACVR1B	3
3308	HSPA4	3
8021	NUP214	3
6885	MAP3K7	4
5747	PTK2	1
2189	FANCG	3
375056	MIA3	1
10000	AKT3	3
9159	PCSK7	1
10186	LHFPL6	2
673	BRAF	5
1213	CLTC	2
4790	NFKB1	6
6011	GRK1	2
4863	NPAT	3
2078	ERG	3
867	CBL	4
6095	RORA	2
8029	CUBN	3
11184	MAP4K1	1
8626	TP63	1
9113	LATS1	3
9064	MAP3K6	2
9451	EIF2AK3	2
11262	SP140	1
8491	MAP4K3	3
4853	NOTCH2	1
157	GRK3	3
3229	HOXC13	3
10010	TANK	4
8312	AXIN1	2
23476	BRD4	3
5728	PTEN	3
57521	RPTOR	3
51592	TRIM33	6
7155	TOP2B	2
80124	VCPIP1	3
22883	CLSTN1	1
284086	NEK8	4
53836	GPR87	1
1950	EGF	2
658	BMPR1B	3
5896	RAG1	3
4055	LTBR	2
7273	TTN	2
79834	PEAK1	1
7454	WAS	2
10257	ABCC4	1
23389	MED13L	4
23411	SIRT1	3
29941	PKN3	3
79012	CAMKV	2
54861	SNRK	1
2046	EPHA8	3
4297	KMT2A	6
558	AXL	3
126792	B3GALT6	1
4619	MYH1	2
2932	GSK3B	6
5581	PRKCE	5
5562	PRKAA1	3
2317	FLNB	5
171389	NLRP6	2
63976	PRDM16	5
3557	IL1RN	6
5335	PLCG1	3
2130	EWSR1	2
131890	GRK7	1
2194	FASN	3
5587	PRKD1	3
5170	PDPK1	2
57448	BIRC6	2
10922	FASTK	2
23139	MAST2	3
22982	DIP2C	3
2157	F8	3
7227	TRPS1	2
8899	PRPF4B	4
4067	LYN	3
65267	WNK3	3
80216	ALPK1	1
5932	RBBP8	2
3977	LIFR	2
7112	TMPO	4
2122	MECOM	3
51167	CYB5R4	3
9212	AURKB	3
4217	MAP3K5	3
63923	TNN	3
1576	CYP3A4	1
7403	KDM6A	4
4638	MYLK	4
51364	ZMYND10	3
197259	MLKL	2
255239	ANKK1	3
5586	PKN2	6
30849	PIK3R4	2
57120	GOPC	1
3480	IGF1R	5
10494	STK25	3
11086	ADAM29	3
3237	HOXD11	1
2073	ERCC5	1
581	BAX	3
3092	HIP1	1
4763	NF1	2
1612	DAPK1	2
5260	PHKG1	10
138474	TAF1L	3
1994	ELAVL1	3
5288	PIK3C2G	5
94	ACVRL1	3
2044	EPHA5	2
4593	MUSK	2
30811	HUNK	5
23683	PRKD3	3
3679	ITGA7	3
81788	NUAK2	3
23112	TNRC6B	2
2178	FANCE	2
27255	CNTN6	3
1499	CTNNB1	4
2444	FRK	1
3440	IFNA2	1
56155	TEX14	3
1436	CSF1R	3
4916	NTRK3	3
2886	GRB7	3

Gene in drug-gene network: Network Plot

Models in Tamatinib

SITE

DATATYPES

CLASSFICATION

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