BID

Summary: This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameBH3 interacting domain death agonist
OMIM IDMIM:601997
Ensembl IDEnsembl:ENSG00000015475
HGNC IDHGNC:HGNC:1050
PHARMGKB IDPA25353
Map Location22q11.21

Gene Categories:

PROTEASETUMOR SUPPRESSOR

GO terms in BID


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0001836 release of cytochrome c from mitochondria
BP IEA GO:0006626 protein targeting to mitochondrion
BP IEA GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
BP TAS GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
BP TAS GO:0008637 apoptotic mitochondrial changes
BP IEA GO:0010918 positive regulation of mitochondrial membrane potential
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Gene expression in normal tissue: BID

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 8UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: undefined model num: 1OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 1LIVEtissue: LIVE cancer: LIVER model num: 0LIVERtissue: LIVER cancer: undefined model num: 1

Gene-drug pathway distribution

undefined4Genome integrity1Chromatin histone acetylation1

Pathways in BID


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Database
Pathway ID
Pathway Des.
wikipathways WP1530 miRNA Regulation of DNA Damage Response
wikipathways WP1742 TP53 Network
wikipathways WP1772 Apoptosis Modulation and Signaling
wikipathways WP2059 Alzheimers Disease
wikipathways WP231 TNF alpha Signaling Pathway
wikipathways WP2447 Amyotrophic lateral sclerosis (ALS)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD885 Compound 110 3
iGMDRD424 Tamatinib 2
iGMDRD1 Nicotin-Amide 1
iGMDRD33 Entinostat 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BID

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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