PAX7
Summary: This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| paired box 7 | MIM:167410 | Ensembl:ENSG00000009709 | HGNC:HGNC:8621 | PA32961 | 1p36.13 |
Gene Categories:
HISTONE MODIFICATIONGO terms in PAX7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006338 | chromatin remodeling |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | IEA | GO:0010453 | regulation of cell fate commitment |
| BP | IEA | GO:0014813 | skeletal muscle satellite cell commitment |
| BP | IEA | GO:0021527 | spinal cord association neuron differentiation |
| BP | IEA | GO:0021904 | dorsal/ventral neural tube patterning |
| BP | IEA | GO:0031062 | positive regulation of histone methylation |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043393 | regulation of protein binding |
| BP | IEA | GO:0043403 | skeletal muscle tissue regeneration |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048663 | neuron fate commitment |
| BP | IEA | GO:0048706 | embryonic skeletal system development |
| BP | IEA | GO:0051216 | cartilage development |
| BP | IEA | GO:0060415 | muscle tissue morphogenesis |
| BP | IEA | GO:2000288 | positive regulation of myoblast proliferation |
| CC | IEA | GO:0005634 | nucleus |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0043565 | sequence-specific DNA binding |
Gene expression in normal tissue: PAX7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PAX7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2023 | Cell Differentiation - Index expanded |
| wikipathways | WP2064 | Neural Crest Differentiation |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD562 | Navitoclax | 9 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD219 | Bax channel blocker | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PAX7
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.