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iGMDRD562

Canonical SMILES: CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

InChI: InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1

InChI Key: JLYAXFNOILIKPP-KXQOOQHDSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Navitoclax	CHEMBL443684	24978500	DB12340	Alone	Small Molecule

Drug Class:

Amides Amines Antineoplastic Agents Sulfones Sulfur Compounds

Drug Targets:

BCL2 (P10415)BCL2L2 (Q92843)BAD (Q92934)

Drug Pathways:

Apoptosis regulation

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	3
64901	RANBP17	2
27125	AFF4	1
4854	NOTCH3	3
7074	TIAM1	1
5027	P2RX7	5
997	CDC34	9
471	ATIC	3
79848	CSPP1	4
7837	PXDN	4
79054	TRPM8	2
23085	ERC1	7
7128	TNFAIP3	1
8444	DYRK3	2
9261	MAPKAPK2	2
21	ABCA3	3
6581	SLC22A3	2
6774	STAT3	3
5933	RBL1	3
8476	CDC42BPA	2
7750	ZMYM2	2
4926	NUMA1	3
2048	EPHB2	3
114801	TMEM200A	3
4627	MYH9	6
5546	PRCC	3
8929	PHOX2B	3
10806	SDCCAG8	2
2956	MSH6	2
55872	PBK	6
57679	ALS2	2
3708	ITPR1	3
1520	CTSS	7
57554	LRRC7	9
1969	EPHA2	4
9706	ULK2	2
9149	DYRK1B	6
817	CAMK2D	3
7272	TTK	6
347365	ITIH6	3
3845	KRAS	3
51347	TAOK3	3
4750	NEK1	4
23097	CDK19	3
2100	ESR2	3
80070	ADAMTS20	2
701	BUB1B	6
3939	LDHA	3
51231	VRK3	9
57143	ADCK1	2
51129	ANGPTL4	3
25778	DSTYK	1
84700	MYO18B	3
4928	NUP98	3
79092	CARD14	3
3431	SP110	4
6597	SMARCA4	2
81035	COLEC12	2
9869	SETDB1	7
7764	ZNF217	5
10395	DLC1	2
5133	PDCD1	4
79820	CATSPERB	3
7444	VRK2	8
7942	TFEB	3
6657	SOX2	3
390502	SERPINA2	2
5754	PTK7	2
64783	RBM15	2
4313	MMP2	3
23235	SIK2	2
4170	MCL1	2
1607	DGKB	7
3694	ITGB6	5
3320	HSP90AA1	2
10142	AKAP9	2
22853	LMTK2	2
7253	TSHR	7
23310	NCAPD3	3
7098	TLR3	5
3195	TLX1	3
5298	PI4KB	3
27	ABL2	2
3841	KPNA5	2
2241	FER	5
6318	SERPINB4	2
9816	URB2	1
84299	MIEN1	2
2249	FGF4	8
54822	TRPM7	6
28231	SLCO4A1	2
202374	STK32A	3
1387	CREBBP	2
1893	ECM1	1
11329	STK38	3
8844	KSR1	6
5788	PTPRC	3
2313	FLI1	2
4283	CXCL9	2
31	ACACA	5
7133	TNFRSF1B	3
9699	RIMS2	4
5596	MAPK4	2
9411	ARHGAP29	9
3604	TNFRSF9	6
29998	BICRA	7
8295	TRRAP	4
2977	GUCY1A2	1
11122	PTPRT	4
5314	PKHD1	3
5605	MAP2K2	3
7158	TP53BP1	5
55294	FBXW7	2
974	CD79B	3
2033	EP300	4
6927	HNF1A	3
8784	TNFRSF18	3
5914	RARA	3
1021	CDK6	6
7852	CXCR4	3
57670	KIAA1549	5
837	CASP4	2
284521	OR2L13	3
440279	UNC13C	4
340156	MYLK4	2
4610	MYCL	8
2115	ETV1	2
4301	AFDN	6
5081	PAX7	9
55819	RNF130	6
84033	OBSCN	3
5607	MAP2K5	2
5900	RALGDS	3
51776	MAP3K20	3
256646	NUTM1	3
2268	FGR	3
1540	CYLD	3
131096	KCNH8	3
122011	CSNK1A1L	4
2051	EPHB6	5
9693	RAPGEF2	2
23012	STK38L	9
222484	LNX2	1
1586	CYP17A1	7
8549	LGR5	2
3714	JAG2	3
32	ACACB	4
8852	AKAP4	2
22806	IKZF3	6
22984	PDCD11	2
6041	RNASEL	1
5468	PPARG	2
200576	PIKFYVE	6
6733	SRPK2	3
1050	CEBPA	1
116986	AGAP2	2
5330	PLCB2	3
10188	TNK2	2
9636	ISG15	1
10217	CTDSPL	2
4216	MAP3K4	4
2736	GLI2	5
29904	EEF2K	3
695	BTK	2
1936	EEF1D	1
3688	ITGB1	3
1984	EIF5A	3
269	AMHR2	2
83931	STK40	1
1143	CHRNB4	2
2045	EPHA7	5
1992	SERPINB1	5
238	ALK	3
375449	MAST4	4
22858	ICK	3
2064	ERBB2	4
85443	DCLK3	2
6850	SYK	3
287015	TRIM42	8
83983	TSSK6	3
65217	PCDH15	5
3916	LAMP1	3
8395	PIP5K1B	4
6663	SOX10	6
9020	MAP3K14	3
993	CDC25A	6
54899	PXK	1
5534	PPP3R1	3
7486	WRN	1
29775	CARD10	3
23387	SIK3	6
1456	CSNK1G3	9
6416	MAP2K4	2
9759	HDAC4	1
92	ACVR2A	4
1452	CSNK1A1	2
8714	ABCC3	2
6709	SPTAN1	2
158056	MAMDC4	4
10087	COL4A3BP	3
50488	MINK1	6
5591	PRKDC	3
8859	STK19	7
80312	TET1	2
5568	PRKACG	3
6464	SHC1	6
6037	RNASE3	2
54437	SEMA5B	3
8515	ITGA10	6
3685	ITGAV	3
3667	IRS1	5
80243	PREX2	5
4605	MYBL2	3
5229	PGGT1B	3
8148	TAF15	3
5924	RASGRF2	3
84433	CARD11	3
9096	TBX18	2
9564	BCAR1	2
4058	LTK	4
1123	CHN1	1
1496	CTNNA2	9
7010	TEK	2
5289	PIK3C3	2
91461	PKDCC	3
23152	CIC	6
2272	FHIT	10
2066	ERBB4	2
904	CCNT1	1
1647	GADD45A	3
5863	RGL2	2
10290	SPEG	1
7184	HSP90B1	2
10062	NR1H3	3
5129	CDK18	3
27436	EML4	3
57523	NYNRIN	4
83694	RPS6KL1	6
2868	GRK4	4
657	BMPR1A	2
5336	PLCG2	6
861	RUNX1	2
149420	PDIK1L	3
7157	TP53	2
2099	ESR1	5
4602	MYB	3
79058	ASPSCR1	2
4855	NOTCH4	2
6794	STK11	1
25836	NIPBL	8
7869	SEMA3B	3
8218	CLTCL1	3
93210	PGAP3	1
54498	SMOX	3
3000	GUCY2D	2
2263	FGFR2	4
572	BAD	3
130399	ACVR1C	3
8408	ULK1	2
5585	PKN1	6
7249	TSC2	4
1019	CDK4	8
7409	VAV1	3
65243	ZFP69B	10
11213	IRAK3	2
84075	FSCB	2
9967	THRAP3	2
105	ADARB2	2
85481	PSKH2	6
4869	NPM1	2
64386	MMP25	3
863	CBFA2T3	3
10516	FBLN5	5
9088	PKMYT1	3
7038	TG	6
369	ARAF	2
4921	DDR2	3
3572	IL6ST	3
6197	RPS6KA3	2
55589	BMP2K	3
57591	MRTFA	3
136332	LRGUK	3
4436	MSH2	2
50945	TBX22	3
7175	TPR	6
5871	MAP4K2	6
80205	CHD9	3
23365	ARHGEF12	2
2081	ERN1	3
8831	SYNGAP1	5
57578	UNC79	4
23269	MGA	2
2175	FANCA	1
4089	SMAD4	7
54658	UGT1A1	1
6654	SOS1	2
672	BRCA1	3
11168	PSIP1	5
1848	DUSP6	4
78989	COLEC11	2
5727	PTCH1	2
9448	MAP4K4	2
285220	EPHA6	2
3426	CFI	6
5297	PI4KA	2
2047	EPHB1	1
5069	PAPPA	4
64840	PORCN	4
340533	NEXMIF	2
3702	ITK	2
440275	EIF2AK4	3
8731	RNMT	1
9972	NUP153	5
3239	HOXD13	6
50615	IL21R	4
84823	LMNB2	9
5290	PIK3CA	2
92335	STRADA	3
6046	BRD2	3
1514	CTSL	6
5034	P4HB	2
1000	CDH2	4
1687	GSDME	2
90	ACVR1	2
5045	FURIN	4
2318	FLNC	5
5530	PPP3CA	4
10155	TRIM28	3
744	MPPED2	5
8445	DYRK2	3
4318	MMP9	1
841	CASP8	8
3065	HDAC1	6
64333	ARHGAP9	6
11064	CNTRL	1
64750	SMURF2	7
2624	GATA2	3
1459	CSNK2A2	2
4684	NCAM1	5
26278	SACS	3
894	CCND2	2
5462	POU5F1B	2
6776	STAT5A	3
51265	CDKL3	2
6446	SGK1	3
5663	PSEN1	2
5592	PRKG1	6
1594	CYP27B1	5
5156	PDGFRA	3
1022	CDK7	3
3635	INPP5D	3
8900	CCNA1	2
375056	MIA3	6
10971	YWHAQ	8
10000	AKT3	3
93627	TBCK	3
27330	RPS6KA6	3
7132	TNFRSF1A	6
3949	LDLR	1
6872	TAF1	2
7153	TOP2A	6
57082	KNL1	1
84630	TTBK1	5
84879	MFSD2A	6
1769	DNAH8	1
23532	PRAME	5
780	DDR1	1
57538	ALPK3	3
120892	LRRK2	4
89795	NAV3	2
65268	WNK2	2
79184	BRCC3	9
867	CBL	3
6095	RORA	2
146057	TTBK2	3
7301	TYRO3	3
93273	LEMD1	2
7468	NSD2	6
8029	CUBN	3
11184	MAP4K1	3
460	ASTN1	2
8178	ELL	3
9064	MAP3K6	2
9321	TRIP11	6
11262	SP140	2
1230	CCR1	2
9509	ADAMTS2	6
3229	HOXC13	6
4791	NFKB2	3
23742	NPAP1	4
23049	SMG1	6
10010	TANK	6
8312	AXIN1	6
1806	DPYD	6
57521	RPTOR	3
4914	NTRK1	2
100187828	HBD	9
22883	CLSTN1	3
1974	EIF4A2	3
3554	IL1R1	3
5305	PIP4K2A	2
2897	GRIK1	5
23542	MAPK8IP2	2
140803	TRPM6	3
6146	RPL22	2
85409	NKD2	3
1950	EGF	2
3678	ITGA5	2
1676	DFFA	3
7042	TGFB2	3
9344	TAOK2	2
1445	CSK	2
8522	GAS7	4
91807	MYLK3	8
5582	PRKCG	2
7465	WEE1	6
2119	ETV5	6
7059	THBS3	3
7454	WAS	9
85415	RHPN2	4
10562	OLFM4	3
8028	MLLT10	3
203447	NRK	3
2277	VEGFD	2
54904	NSD3	2
23411	SIRT1	6
8648	NCOA1	2
387	RHOA	3
3161	HMMR	4
9372	ZFYVE9	3
7150	TOP1	3
10243	GPHN	3
84930	MASTL	2
282974	STK32C	3
9943	OXSR1	3
286151	FBXO43	4
10595	ERN2	3
2072	ERCC4	3
344905	ATP13A5	3
5588	PRKCQ	3
51151	SLC45A2	3
5291	PIK3CB	7
1493	CTLA4	3
10076	PTPRU	2
558	AXL	2
126792	B3GALT6	7
9748	SLK	6
57680	CHD8	5
3297	HSF1	3
2690	GHR	7
10111	RAD50	6
9223	MAGI1	6
171389	NLRP6	6
3181	HNRNPA2B1	3
152110	NEK10	3
1281	COL3A1	2
9659	PDE4DIP	8
9201	DCLK1	6
63976	PRDM16	5
4000	LMNA	3
2049	EPHB3	3
283455	KSR2	4
6093	ROCK1	2
131890	GRK7	3
1719	DHFR	3
5583	PRKCH	6
900	CCNG1	2
5170	PDPK1	6
57448	BIRC6	3
2131	EXT1	3
5681	PSKH1	3
7227	TRPS1	2
53335	BCL11A	5
79837	PIP4K2C	4
3709	ITPR2	3
57147	SCYL3	5
11040	PIM2	2
4221	MEN1	3
8899	PRPF4B	6
8550	MAPKAPK5	3
23301	EHBP1	6
65267	WNK3	8
150094	SIK1	2
8428	STK24	1
3516	RBPJ	6
3552	IL1A	2
4261	CIITA	6
4330	MN1	5
84072	HORMAD1	9
23512	SUZ12	9
444	ASPH	2
11076	TPPP	3
23250	ATP11A	3
182	JAG1	2
2122	MECOM	2
3662	IRF4	6
51167	CYB5R4	2
1760	DMPK	2
9212	AURKB	3
6653	SORL1	3
2903	GRIN2A	5
5925	RB1	4
4893	NRAS	1
5584	PRKCI	3
1026	CDKN1A	2
63923	TNN	2
25	ABL1	4
5324	PLAG1	3
8661	EIF3A	3
7403	KDM6A	2
8717	TRADD	3
7508	XPC	2
4302	MLLT6	6
197259	MLKL	4
7040	TGFB1	3
30849	PIK3R4	2
50964	SOST	6
23092	ARHGAP26	3
4299	AFF1	4
5049	PAFAH1B2	3
2651	GCNT2	2
9262	STK17B	3
374	AREG	3
23072	HECW1	6
5567	PRKACB	6
4040	LRP6	4
84446	BRSK1	4
79966	SCD5	6
57697	FANCM	4
1612	DAPK1	3
5260	PHKG1	5
55791	LRIF1	5
1994	ELAVL1	6
4613	MYCN	1
10891	PPARGC1A	3
5288	PIK3C2G	3
5287	PIK3C2B	2
30811	HUNK	6
3679	ITGA7	2
81788	NUAK2	6
10048	RANBP9	4
4193	MDM2	1
6868	ADAM17	2
27255	CNTN6	2
83732	RIOK1	6
29110	TBK1	5
1499	CTNNB1	5
2444	FRK	3
27151	CPAMD8	6
56155	TEX14	6
5602	MAPK10	6
1436	CSF1R	2
4916	NTRK3	2
167359	NIM1K	2
11035	RIPK3	4
5624	PROC	8
5970	RELA	2

Gene in drug-gene network: Network Plot

Models in Navitoclax

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.