Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008].

C-C motif chemokine receptor 1MIM:601159Ensembl:ENSG00000163823HGNC:HGNC:1602PA261663p21.31

GO terms in CCR1

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005886plasma membrane
CCIMPGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIBAGO:0009897external side of plasma membrane
CCIDAGO:0009897external side of plasma membrane
BPTASGO:0002407dendritic cell chemotaxis
BPIDAGO:0006816calcium ion transport
BPIDAGO:0006874cellular calcium ion homeostasis
BPIBAGO:0006954inflammatory response
BPIEAGO:0006954inflammatory response
BPIBAGO:0006955immune response
BPIDAGO:0006955immune response
BPTASGO:0007155cell adhesion
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BPIBAGO:0007204positive regulation of cytosolic calcium ion concentration
BPIDAGO:0007204positive regulation of cytosolic calcium ion concentration
BPIDAGO:0007267cell-cell signaling
BPTASGO:0009611response to wounding
BPIMPGO:0010629negative regulation of gene expression
BPNASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPIBAGO:0019722calcium-mediated signaling
BPIMPGO:0030335positive regulation of cell migration
BPIMPGO:0030502negative regulation of bone mineralization
BPIMPGO:0045672positive regulation of osteoclast differentiation
BPIDAGO:0051928positive regulation of calcium ion transport
BPIBAGO:0060326cell chemotaxis
BPIDAGO:0070098chemokine-mediated signaling pathway
BPIMPGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0090026positive regulation of monocyte chemotaxis
MFIDAGO:0004435phosphatidylinositol phospholipase C activity
MFIDAGO:0004950chemokine receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0016493C-C chemokine receptor activity
MFIDAGO:0016493C-C chemokine receptor activity
MFIBAGO:0019956chemokine binding
MFIBAGO:0019957C-C chemokine binding
MFIPIGO:0019957C-C chemokine binding
MFIBAGO:0035717chemokine (C-C motif) ligand 7 binding
MFIPIGO:0035717chemokine (C-C motif) ligand 7 binding
MFIBAGO:0071791chemokine (C-C motif) ligand 5 binding
MFIPIGO:0071791chemokine (C-C motif) ligand 5 binding

Gene expression in normal tissue: CCR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCR1

DatabasePathway IDPathway Des.
wikipathwaysWP24Peptide GPCRs
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-380108Chemokine receptors bind chemokines
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-6783783Interleukin-10 signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD286Nsc 6328393
iGMDRD297Austocystin D5
iGMDRD61Kinetin riboside5
iGMDRD446LY 21832401
iGMDRD307Manumycin A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCR1