CCR1
Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C-C motif chemokine receptor 1 | MIM:601159 | Ensembl:ENSG00000163823 | HGNC:HGNC:1602 | PA26166 | 3p21.31 |
GO terms in CCR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IMP | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| BP | TAS | GO:0002407 | dendritic cell chemotaxis |
| BP | IDA | GO:0006816 | calcium ion transport |
| BP | IDA | GO:0006874 | cellular calcium ion homeostasis |
| BP | IDA | GO:0006887 | exocytosis |
| BP | IBA | GO:0006935 | chemotaxis |
| BP | NAS | GO:0006935 | chemotaxis |
| BP | IBA | GO:0006954 | inflammatory response |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IBA | GO:0006955 | immune response |
| BP | IDA | GO:0006955 | immune response |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| BP | IBA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IDA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IDA | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0009611 | response to wounding |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | NAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0019722 | calcium-mediated signaling |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0030502 | negative regulation of bone mineralization |
| BP | IMP | GO:0045672 | positive regulation of osteoclast differentiation |
| BP | IDA | GO:0051928 | positive regulation of calcium ion transport |
| BP | IBA | GO:0060326 | cell chemotaxis |
| BP | IDA | GO:0070098 | chemokine-mediated signaling pathway |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0090026 | positive regulation of monocyte chemotaxis |
| MF | IDA | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | IDA | GO:0004950 | chemokine receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016493 | C-C chemokine receptor activity |
| MF | IDA | GO:0016493 | C-C chemokine receptor activity |
| MF | IBA | GO:0019956 | chemokine binding |
| MF | IBA | GO:0019957 | C-C chemokine binding |
| MF | IPI | GO:0019957 | C-C chemokine binding |
| MF | IBA | GO:0035717 | chemokine (C-C motif) ligand 7 binding |
| MF | IPI | GO:0035717 | chemokine (C-C motif) ligand 7 binding |
| MF | IBA | GO:0071791 | chemokine (C-C motif) ligand 5 binding |
| MF | IPI | GO:0071791 | chemokine (C-C motif) ligand 5 binding |
Gene expression in normal tissue: CCR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP24 | Peptide GPCRs |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-380108 | Chemokine receptors bind chemokines |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD307 | Manumycin A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCR1
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