WRN
Summary: This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Werner syndrome RecQ like helicase | MIM:604611 | Ensembl:ENSG00000165392 | HGNC:HGNC:12791 | PA367 | 8p12 |
Gene Categories:
DNA REPAIRGO terms in WRN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000287 | magnesium ion binding |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0000400 | four-way junction DNA binding |
| MF | IDA | GO:0000400 | four-way junction DNA binding |
| MF | IBA | GO:0000403 | Y-form DNA binding |
| MF | IDA | GO:0000403 | Y-form DNA binding |
| MF | IBA | GO:0000405 | bubble DNA binding |
| MF | IDA | GO:0000405 | bubble DNA binding |
| MF | IBA | GO:0003677 | DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IDA | GO:0003678 | DNA helicase activity |
| MF | IMP | GO:0003678 | DNA helicase activity |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0004003 | ATP-dependent DNA helicase activity |
| MF | IDA | GO:0004386 | helicase activity |
| MF | IDA | GO:0004527 | exonuclease activity |
| MF | IMP | GO:0004527 | exonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008408 | 3'-5' exonuclease activity |
| MF | IDA | GO:0008408 | 3'-5' exonuclease activity |
| MF | IBA | GO:0009378 | four-way junction helicase activity |
| MF | IDA | GO:0009378 | four-way junction helicase activity |
| MF | IDA | GO:0016887 | ATPase activity |
| MF | IBA | GO:0030145 | manganese ion binding |
| MF | IDA | GO:0030145 | manganese ion binding |
| MF | IBA | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0043138 | 3'-5' DNA helicase activity |
| MF | IBA | GO:0043140 | ATP-dependent 3'-5' DNA helicase activity |
| MF | IDA | GO:0044877 | protein-containing complex binding |
| MF | IDA | GO:0051880 | G-quadruplex DNA binding |
| MF | IBA | GO:0061749 | forked DNA-dependent helicase activity |
| MF | IDA | GO:0061749 | forked DNA-dependent helicase activity |
| MF | IBA | GO:0061821 | telomeric D-loop binding |
| MF | IDA | GO:0061821 | telomeric D-loop binding |
| MF | IC | GO:0061849 | telomeric G-quadruplex DNA binding |
| MF | IBA | GO:0070337 | 3'-flap-structured DNA binding |
| MF | IDA | GO:0070337 | 3'-flap-structured DNA binding |
| MF | IBA | GO:1905773 | 8-hydroxy-2'-deoxyguanosine DNA binding |
| MF | IDA | GO:1905773 | 8-hydroxy-2'-deoxyguanosine DNA binding |
| CC | IBA | GO:0000781 | chromosome, telomeric region |
| CC | IDA | GO:0000781 | chromosome, telomeric region |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005657 | replication fork |
| CC | ISS | GO:0005657 | replication fork |
| CC | IBA | GO:0005662 | DNA replication factor A complex |
| CC | IBA | GO:0005694 | chromosome |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IBA | GO:0032389 | MutLalpha complex |
| CC | IDA | GO:0032389 | MutLalpha complex |
| CC | IBA | GO:0035861 | site of double-strand break |
| CC | IEA | GO:0043005 | neuron projection |
| BP | IMP | GO:0000723 | telomere maintenance |
| BP | TAS | GO:0000723 | telomere maintenance |
| BP | IBA | GO:0000724 | double-strand break repair via homologous recombination |
| BP | IBA | GO:0000731 | DNA synthesis involved in DNA repair |
| BP | IDA | GO:0000731 | DNA synthesis involved in DNA repair |
| BP | IBA | GO:0001302 | replicative cell aging |
| BP | IEA | GO:0001302 | replicative cell aging |
| BP | IDA | GO:0006259 | DNA metabolic process |
| BP | IMP | GO:0006260 | DNA replication |
| BP | ISS | GO:0006260 | DNA replication |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IBA | GO:0006281 | DNA repair |
| BP | IBA | GO:0006284 | base-excision repair |
| BP | IDA | GO:0006284 | base-excision repair |
| BP | IMP | GO:0006302 | double-strand break repair |
| BP | IBA | GO:0006310 | DNA recombination |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IBA | GO:0006979 | response to oxidative stress |
| BP | IDA | GO:0006979 | response to oxidative stress |
| BP | IEA | GO:0007420 | brain development |
| BP | NAS | GO:0007568 | aging |
| BP | IBA | GO:0007569 | cell aging |
| BP | IMP | GO:0007569 | cell aging |
| BP | IBA | GO:0008340 | determination of adult lifespan |
| BP | IBA | GO:0009267 | cellular response to starvation |
| BP | IDA | GO:0009267 | cellular response to starvation |
| BP | IBA | GO:0010225 | response to UV-C |
| BP | IDA | GO:0010225 | response to UV-C |
| BP | IBA | GO:0010259 | multicellular organism aging |
| BP | IMP | GO:0010259 | multicellular organism aging |
| BP | IBA | GO:0031297 | replication fork processing |
| BP | IDA | GO:0031297 | replication fork processing |
| BP | IMP | GO:0031297 | replication fork processing |
| BP | IBA | GO:0032508 | DNA duplex unwinding |
| BP | IDA | GO:0032508 | DNA duplex unwinding |
| BP | IEA | GO:0040009 | regulation of growth rate |
| BP | IBA | GO:0042981 | regulation of apoptotic process |
| BP | IGI | GO:0042981 | regulation of apoptotic process |
| BP | IBA | GO:0044806 | G-quadruplex DNA unwinding |
| BP | IDA | GO:0044806 | G-quadruplex DNA unwinding |
| BP | ISS | GO:0044806 | G-quadruplex DNA unwinding |
| BP | IBA | GO:0051345 | positive regulation of hydrolase activity |
| BP | IDA | GO:0051345 | positive regulation of hydrolase activity |
| BP | IBA | GO:0061820 | telomeric D-loop disassembly |
| BP | IDA | GO:0061820 | telomeric D-loop disassembly |
| BP | IGI | GO:0061820 | telomeric D-loop disassembly |
| BP | TAS | GO:0061820 | telomeric D-loop disassembly |
| BP | IBA | GO:0071480 | cellular response to gamma radiation |
| BP | IDA | GO:0071480 | cellular response to gamma radiation |
| BP | IEA | GO:0090305 | nucleic acid phosphodiester bond hydrolysis |
| BP | TAS | GO:0090656 | t-circle formation |
| BP | IBA | GO:0098530 | positive regulation of strand invasion |
| BP | IDA | GO:0098530 | positive regulation of strand invasion |
| BP | IDA | GO:1902570 | protein localization to nucleolus |
Gene expression in normal tissue: WRN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WRN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5685938 | HDR through Single Strand Annealing (SSA) |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693537 | Resolution of D-Loop Structures |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| reactome | R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| pid | telomerasepathway | Regulation of Telomerase |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD159 | 3-Chloro-L-alanine | 3 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD484 | Pluripotin | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD207 | Capsaicin | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD299 | ICL 670 | 1 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD322 | FK 866 | 6 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD434 | BMS-536924 | 7 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD202 | Curcumin | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WRN
CLASSFICATION
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