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iGMDRD781

Canonical SMILES: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC

InChI: InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17-,35-25+/t30-,32-,33?,34+,36-,37?,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1

InChI Key: QFJCIRLUMZQUOT-GWUMUYGYSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
Sirolimus	CHEMBL1329171 CHEMBL413	73707400	Alone	Small Molecule

Drug Targets:

MTORC1

Drug Pathways:

PI3K/MTOR signaling Type I polyketide structures Longevity regulating pathway Longevity regulating pathway - worm Cellular senescence

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3696	ITGB8	2
4854	NOTCH3	6
8019	BRD3	1
5296	PIK3R2	3
5027	P2RX7	3
997	CDC34	3
79848	CSPP1	2
7535	ZAP70	3
10221	TRIB1	3
23085	ERC1	4
7128	TNFAIP3	1
6774	STAT3	6
7750	ZMYM2	2
4926	NUMA1	4
11183	MAP4K5	2
2048	EPHB2	3
4627	MYH9	4
5546	PRCC	3
8929	PHOX2B	3
4168	MCF2	3
23513	SCRIB	2
2200	FBN1	2
55872	PBK	6
4303	FOXO4	1
1520	CTSS	5
57554	LRRC7	7
9706	ULK2	2
9149	DYRK1B	7
347365	ITIH6	1
3845	KRAS	3
4750	NEK1	3
5295	PIK3R1	1
137994	LETM2	3
701	BUB1B	2
8573	CASK	1
3939	LDHA	7
51231	VRK3	3
51129	ANGPTL4	3
2335	FN1	2
84700	MYO18B	3
3205	HOXA9	3
53616	ADAM22	6
3431	SP110	2
4352	MPL	3
6938	TCF12	3
2475	MTOR	6
3551	IKBKB	1
81035	COLEC12	3
3326	HSP90AB1	1
9869	SETDB1	8
7764	ZNF217	8
2176	FANCC	3
10395	DLC1	1
5241	PGR	3
353345	GPR141	2
79820	CATSPERB	5
7444	VRK2	3
6657	SOX2	3
390502	SERPINA2	8
4771	NF2	3
10863	ADAM28	3
6598	SMARCB1	2
4170	MCL1	6
1607	DGKB	2
3694	ITGB6	2
5218	CDK14	2
10142	AKAP9	3
22853	LMTK2	3
7098	TLR3	2
5298	PI4KB	3
3841	KPNA5	1
2241	FER	5
340371	NRBP2	3
114908	TMEM123	3
1032	CDKN2D	3
79934	COQ8B	2
54822	TRPM7	3
51199	NIN	1
80122	MAP3K19	3
28231	SLCO4A1	3
114783	LMTK3	1
1893	ECM1	2
8844	KSR1	4
5788	PTPRC	4
7133	TNFRSF1B	3
1602	DACH1	4
9048	ARTN	5
5596	MAPK4	6
9411	ARHGAP29	1
29998	BICRA	4
26576	SRPK3	1
2977	GUCY1A2	1
5159	PDGFRB	2
7373	COL14A1	1
55351	STK32B	3
7173	TPO	6
4851	NOTCH1	3
5314	PKHD1	1
5605	MAP2K2	3
51512	GTSE1	3
7158	TP53BP1	2
89910	UBE3B	3
55294	FBXW7	1
974	CD79B	3
2033	EP300	2
54567	DLL4	2
8784	TNFRSF18	12
9578	CDC42BPB	2
641	BLM	2
64324	NSD1	5
57670	KIAA1549	3
22861	NLRP1	2
284521	OR2L13	3
440279	UNC13C	4
2115	ETV1	4
4301	AFDN	4
816	CAMK2B	2
5081	PAX7	3
5743	PTGS2	2
51776	MAP3K20	3
2268	FGR	7
1540	CYLD	2
11073	TOPBP1	3
122011	CSNK1A1L	2
4478	MSN	1
8549	LGR5	4
6256	RXRA	4
1591	CYP24A1	7
32	ACACB	2
22806	IKZF3	3
2242	FES	6
3091	HIF1A	3
10342	TFG	9
4005	LMO2	5
22984	PDCD11	6
8313	AXIN2	5
6733	SRPK2	3
6091	ROBO1	5
116986	AGAP2	2
51343	FZR1	3
5330	PLCB2	3
23255	MTCL1	5
730249	ACOD1	3
4216	MAP3K4	2
83990	BRIP1	3
4739	NEDD9	4
9098	USP6	4
6928	HNF1B	3
4194	MDM4	3
4982	TNFRSF11B	2
2045	EPHA7	2
1992	SERPINB1	3
399979	SNX19	1
22858	ICK	2
94103	ORMDL3	1
57476	GRAMD1B	2
8395	PIP5K1B	2
6663	SOX10	3
9020	MAP3K14	3
993	CDC25A	4
55361	PI4K2A	3
7486	WRN	2
23191	CYFIP1	3
5573	PRKAR1A	3
1456	CSNK1G3	3
783	CACNB2	7
9759	HDAC4	3
92	ACVR2A	3
8714	ABCC3	3
57510	XPO5	5
25989	ULK3	3
6709	SPTAN1	1
219970	GLYATL2	1
1973	EIF4A1	3
1909	EDNRA	1
158056	MAMDC4	3
10087	COL4A3BP	3
80312	TET1	1
79705	LRRK1	3
5568	PRKACG	3
6464	SHC1	5
157285	PRAG1	3
54437	SEMA5B	3
8515	ITGA10	5
472	ATM	9
8945	BTRC	3
2580	GAK	4
5229	PGGT1B	2
139285	AMER1	11
3418	IDH2	2
8148	TAF15	5
28996	HIPK2	4
575	ADGRB1	3
53942	CNTN5	4
5575	PRKAR1B	2
4087	SMAD2	2
11344	TWF2	3
55851	PSENEN	3
54986	ULK4	2
1496	CTNNA2	7
7010	TEK	4
7533	YWHAH	1
5450	POU2AF1	5
898	CCNE1	4
23152	CIC	8
2050	EPHB4	2
2272	FHIT	1
2066	ERBB4	2
5327	PLAT	8
5863	RGL2	5
51517	NCKIPSD	1
10290	SPEG	3
9319	TRIP13	6
2201	FBN2	1
1029	CDKN2A	1
139728	PNCK	3
5129	CDK18	2
27436	EML4	1
284656	EPHA10	1
57523	NYNRIN	2
8576	STK16	3
657	BMPR1A	3
10018	BCL2L11	5
27347	STK39	3
11197	WIF1	1
58508	KMT2C	5
648	BMI1	3
7157	TP53	2
7704	ZBTB16	3
79058	ASPSCR1	4
6794	STK11	2
57194	ATP10A	3
25836	NIPBL	2
57410	SCYL1	2
5910	RAP1GDS1	6
10114	HIPK3	3
836	CASP3	2
6184	RPN1	4
84513	PLPP5	6
2263	FGFR2	1
2133	EXT3	4
225689	MAPK15	5
106480993	RN7SL263P	3
5585	PKN1	6
9639	ARHGEF10	2
7249	TSC2	4
1019	CDK4	5
84075	FSCB	2
9967	THRAP3	5
5604	MAP2K1	3
4869	NPM1	6
64386	MMP25	3
344387	CDKL4	3
863	CBFA2T3	5
1555	CYP2B6	2
7422	VEGFA	3
5600	MAPK11	10
2309	FOXO3	3
369	ARAF	6
4921	DDR2	3
3572	IL6ST	3
5077	PAX3	3
6197	RPS6KA3	5
3187	HNRNPH1	2
57591	MRTFA	3
136332	LRGUK	3
652	BMP4	5
6535	SLC6A8	1
676	BRDT	2
7175	TPR	1
5871	MAP4K2	9
2081	ERN1	3
8831	SYNGAP1	2
4026	LPP	1
8997	KALRN	2
6280	S100A9	3
5610	EIF2AK2	3
4089	SMAD4	1
6654	SOS1	1
672	BRCA1	2
2060	EPS15	2
1616	DAXX	3
11168	PSIP1	7
1848	DUSP6	2
7204	TRIO	3
256536	TCERG1L	1
9252	RPS6KA5	5
5727	PTCH1	6
546	ATRX	4
3426	CFI	12
23678	SGK3	2
3558	IL2	6
64840	PORCN	4
57144	PAK5	3
286133	SCARA5	1
4214	MAP3K1	6
440275	EIF2AK4	3
8731	RNMT	2
84823	LMNB2	4
92335	STRADA	3
6046	BRD2	2
3720	JARID2	3
5034	P4HB	3
1000	CDH2	1
4145	MATK	3
1687	GSDME	5
4293	MAP3K9	6
253260	RICTOR	3
5366	PMAIP1	3
5530	PPP3CA	5
3458	IFNG	4
10155	TRIM28	3
7075	TIE1	3
744	MPPED2	3
1956	EGFR	6
841	CASP8	3
3065	HDAC1	6
4609	MYC	3
64333	ARHGAP9	4
64750	SMURF2	4
90956	ADCK2	3
3308	HSPA4	6
5789	PTPRD	4
1459	CSNK2A2	4
8013	NR4A3	6
10461	MERTK	2
26278	SACS	7
896	CCND3	2
29951	PDZRN4	2
6776	STAT5A	2
51701	NLK	2
6446	SGK1	3
79759	ZNF668	2
1594	CYP27B1	2
5747	PTK2	2
3635	INPP5D	6
8900	CCNA1	6
7917	BAG6	8
375056	MIA3	5
10971	YWHAQ	5
93627	TBCK	2
7132	TNFRSF1A	3
7189	TRAF6	9
3949	LDLR	8
56924	PAK6	2
23005	MAPKBP1	4
6872	TAF1	3
673	BRAF	5
7153	TOP2A	3
57082	KNL1	1
1981	EIF4G1	2
1213	CLTC	3
4790	NFKB1	3
780	DDR1	7
8924	HERC2	2
120892	LRRK2	4
89795	NAV3	3
79184	BRCC3	1
2867	FFAR2	3
6095	RORA	10
146057	TTBK2	3
1677	DFFB	2
7301	TYRO3	2
93273	LEMD1	5
5205	ATP8B1	2
8626	TP63	5
9113	LATS1	2
9064	MAP3K6	2
1024	CDK8	7
10253	SPRY2	1
55290	BRF2	6
266747	RGL4	2
3229	HOXC13	3
8621	CDK13	5
23598	PATZ1	3
23396	PIP5K1C	4
23049	SMG1	2
10010	TANK	8
10752	CHL1	3
23476	BRD4	5
5728	PTEN	8
57521	RPTOR	3
5595	MAPK3	3
8888	MCM3AP	2
1869	E2F1	1
80124	VCPIP1	3
4914	NTRK1	3
667	DST	4
23281	MTUS2	5
115701	ALPK2	2
83666	PARP9	1
1613	DAPK3	3
140803	TRPM6	3
6770	STAR	3
2188	FANCF	4
2324	FLT4	2
10962	MLLT11	5
1950	EGF	4
3678	ITGA5	2
2870	GRK6	1
6498	SKIL	3
4055	LTBR	3
1445	CSK	8
91807	MYLK3	3
79834	PEAK1	3
5582	PRKCG	2
56616	DIABLO	3
995	CDC25C	3
7465	WEE1	3
10257	ABCC4	3
596	BCL2	3
6787	NEK4	1
2277	VEGFD	2
54904	NSD3	6
23411	SIRT1	3
387	RHOA	3
29941	PKN3	3
79012	CAMKV	3
10249	GLYAT	2
1027	CDKN1B	2
10243	GPHN	4
22843	PPM1E	3
8394	PIP5K1A	6
23305	ACSL6	3
10595	ERN2	3
5291	PIK3CB	3
7248	TSC1	3
126792	B3GALT6	5
83417	FCRL4	4
57680	CHD8	3
2690	GHR	3
2317	FLNB	3
9021	SOCS3	6
10111	RAD50	3
9223	MAGI1	6
5395	PMS2	1
55289	ACOXL	3
9659	PDE4DIP	2
63976	PRDM16	3
7293	TNFRSF4	6
283455	KSR2	11
5335	PLCG1	3
2776	GNAQ	2
3624	INHBA	1
2194	FASN	2
4628	MYH10	3
598	BCL2L1	1
2213	FCGR2B	2
3579	CXCR2	6
5587	PRKD1	1
1719	DHFR	3
5583	PRKCH	3
10734	STAG3	2
5170	PDPK1	3
2321	FLT1	3
5681	PSKH1	3
3717	JAK2	4
2157	F8	2
7227	TRPS1	3
79837	PIP4K2C	4
57147	SCYL3	1
8899	PRPF4B	4
4067	LYN	3
65267	WNK3	3
5603	MAPK13	3
8428	STK24	3
3516	RBPJ	3
6777	STAT5B	2
3552	IL1A	3
3977	LIFR	1
5915	RARB	3
4261	CIITA	4
84072	HORMAD1	5
23512	SUZ12	5
11076	TPPP	5
3662	IRF4	2
51167	CYB5R4	3
6653	SORL1	2
2903	GRIN2A	4
5925	RB1	3
4666	NACA	3
4893	NRAS	4
2074	ERCC6	4
10420	TESK2	3
7403	KDM6A	3
54790	TET2	8
2308	FOXO1	1
2534	FYN	3
81629	TSSK3	3
8841	HDAC3	1
4638	MYLK	4
255239	ANKK1	1
7040	TGFB1	1
30849	PIK3R4	2
3488	IGFBP5	3
2011	MARK2	7
79728	PALB2	2
23092	ARHGAP26	3
4299	AFF1	4
142	PARP1	5
2261	FGFR3	1
5567	PRKACB	3
4040	LRP6	2
1013	CDH15	3
595	CCND1	6
4763	NF1	9
57697	FANCM	2
5260	PHKG1	3
55791	LRIF1	1
9625	AATK	1
1994	ELAVL1	3
4613	MYCN	1
10891	PPARGC1A	4
2044	EPHA5	1
2246	FGF1	3
23683	PRKD3	2
3679	ITGA7	1
6943	TCF21	6
699	BUB1	2
6868	ADAM17	6
23112	TNRC6B	2
2178	FANCE	6
29110	TBK1	4
3895	KTN1	1
27151	CPAMD8	4
56155	TEX14	5
2892	GRIA3	3
1436	CSF1R	9
4916	NTRK3	3
5624	PROC	3
5970	RELA	3
5685	PSMA4	6

Gene in drug-gene network: Network Plot

Models in Sirolimus

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.