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HSP90AB1

Summary: This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameheat shock protein 90 alpha family class B member 1 OMIM IDMIM:140572 Ensembl IDEnsembl:ENSG00000096384 HGNC IDHGNC:HGNC:5258 PHARMGKB IDPA29524 Map Location6p21.1

Gene Categories:

RNA DIRECTED DNA POLYMERASE SERINE THREONINE KINASE DRUGGABLE GENOME PROTEIN PHOSPHATASE CELL SURFACE TUMOR SUPPRESSOR KINASE DRUG RESISTANCE

GO terms in HSP90AB1

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0002134	UTP binding
MF	IEA	GO:0002135	CTP binding
MF	HDA	GO:0003723	RNA binding
MF	IDA	GO:0003725	double-stranded RNA binding
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005524	ATP binding

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Gene expression in normal tissue: HSP90AB1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HSP90AB1

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Database	Pathway ID	Pathway Des.
netpath	Pathway_TCR	TCR
netpath	Pathway_TNFalpha	TNFalpha
pid	vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2
kegg	hsa04141	Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa04217	Necroptosis - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD158	NSC141540	1
iGMDRD121	GMX1778	3
iGMDRD871	BRD6368	3
iGMDRD329	Merck60	5

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSP90AB1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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