HSP90AB1


Summary: This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
heat shock protein 90 alpha family class B member 1MIM:140572Ensembl:ENSG00000096384HGNC:HGNC:5258PA295246p21.1

GO terms in HSP90AB1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0002134UTP binding
MFIEAGO:0002135CTP binding
MFHDAGO:0003723RNA binding
MFIDAGO:0003725double-stranded RNA binding
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIMPGO:0005524ATP binding
MFIEAGO:0005525GTP binding
MFIEAGO:0017098sulfonylurea receptor binding
MFIEAGO:0019887protein kinase regulator activity
MFIPIGO:0019900kinase binding
MFIEAGO:0019901protein kinase binding
MFHDAGO:0023026MHC class II protein complex binding
MFISSGO:0030235nitric-oxide synthase regulator activity
MFISSGO:0030911TPR domain binding
MFIPIGO:0031072heat shock protein binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIEAGO:0032564dATP binding
MFIPIGO:0042277peptide binding
MFTASGO:0042623ATPase activity, coupled
MFIPIGO:0042802identical protein binding
MFIDAGO:0042803protein homodimerization activity
MFIPIGO:0042826histone deacetylase binding
MFIPIGO:0043008ATP-dependent protein binding
MFIEAGO:0044325ion channel binding
MFHDAGO:0045296cadherin binding
MFIDAGO:0046983protein dimerization activity
MFIEAGO:0048156tau protein binding
MFIEAGO:0051082unfolded protein binding
MFIPIGO:0070182DNA polymerase binding
MFIPIGO:0097718disordered domain specific binding
MFIPIGO:1990226histone methyltransferase binding
BPIEAGO:0001890placenta development
BPIEAGO:0006457protein folding
BPTASGO:0006805xenobiotic metabolic process
BPNASGO:0006986response to unfolded protein
BPIDAGO:0007004telomere maintenance via telomerase
BPIEAGO:0009651response to salt stress
BPIMPGO:0019062virion attachment to host cell
BPISSGO:0021955central nervous system neuron axonogenesis
BPISSGO:0030010establishment of cell polarity
BPIDAGO:0030511positive regulation of transforming growth factor beta receptor signaling pathway
BPIDAGO:0031396regulation of protein ubiquitination
BPIEAGO:0032092positive regulation of protein binding
BPIDAGO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIMPGO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIDAGO:0032516positive regulation of phosphoprotein phosphatase activity
BPISSGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIEAGO:0033160positive regulation of protein import into nucleus, translocation
BPIEAGO:0035690cellular response to drug
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPIEAGO:0042220response to cocaine
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPISSGO:0045429positive regulation of nitric oxide biosynthetic process
BPIMPGO:0045597positive regulation of cell differentiation
BPIEAGO:0045793positive regulation of cell size
BPISSGO:0048675axon extension
BPTASGO:0050821protein stabilization
BPIDAGO:0051131chaperone-mediated protein complex assembly
BPISSGO:0051248negative regulation of protein metabolic process
BPISSGO:0051897positive regulation of protein kinase B signaling
BPIDAGO:0051973positive regulation of telomerase activity
BPIMPGO:0060334regulation of interferon-gamma-mediated signaling pathway
BPIMPGO:0060338regulation of type I interferon-mediated signaling pathway
BPIMPGO:0071157negative regulation of cell cycle arrest
BPIEAGO:0071353cellular response to interleukin-4
BPIEAGO:0071407cellular response to organic cyclic compound
BPIEAGO:0071902positive regulation of protein serine/threonine kinase activity
BPIMPGO:0097435supramolecular fiber organization
BPTASGO:1900034regulation of cellular response to heat
BPIDAGO:1901389negative regulation of transforming growth factor beta activation
BPISSGO:1901799negative regulation of proteasomal protein catabolic process
BPICGO:1902949positive regulation of tau-protein kinase activity
BPIEAGO:1903660negative regulation of complement-dependent cytotoxicity
BPISSGO:1903827regulation of cellular protein localization
BPISSGO:1904031positive regulation of cyclin-dependent protein kinase activity
BPIDAGO:1905323telomerase holoenzyme complex assembly
BPIDAGO:2000010positive regulation of protein localization to cell surface
CCIDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCHDAGO:0005739mitochondrion
CCIEAGO:0005765lysosomal membrane
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0008180COP9 signalosome
CCIEAGO:0009986cell surface
CCHDAGO:0016020membrane
CCIEAGO:0016234inclusion body
CCIEAGO:0016323basolateral plasma membrane
CCIEAGO:0016324apical plasma membrane
CCIEAGO:0031526brush border membrane
CCIDAGO:0032991protein-containing complex
CCIMPGO:0032991protein-containing complex
CCIDAGO:0034751aryl hydrocarbon receptor complex
CCTASGO:0034774secretory granule lumen
CCIEAGO:0042470melanosome
CCISSGO:0043025neuronal cell body
CCISSGO:0044294dendritic growth cone
CCISSGO:0044295axonal growth cone
CCISSGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
CCTASGO:1904813ficolin-1-rich granule lumen
CCIEAGO:1990913sperm head plasma membrane
CCIEAGO:1990917ooplasm

Gene expression in normal tissue: HSP90AB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HSP90AB1


DatabasePathway IDPathway Des.
netpathPathway_TCRTCR
netpathPathway_TNFalphaTNFalpha
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04612Antigen processing and presentation - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1643685Disease
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-211945Phase I - Functionalization of compounds
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3371497HSP90 chaperone cycle for steroid hormone receptors (SHR)
reactomeR-HSA-3371511HSF1 activation
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-3371568Attenuation phase
reactomeR-HSA-3371571HSF1-dependent transactivation
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-399954Sema3A PAK dependent Axon repulsion
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-5336415Uptake and function of diphtheria toxin
reactomeR-HSA-5339562Uptake and actions of bacterial toxins
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-622312Inflammasomes
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-844456The NLRP3 inflammasome
reactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpoint
reactomeR-HSA-8937144Aryl hydrocarbon receptor signalling
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006931Signaling by Nuclear Receptors
reactomeR-HSA-9018519Estrogen-dependent gene expression

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD158NSC1415401
iGMDRD121GMX17783
iGMDRD871BRD63683
iGMDRD329Merck605
iGMDRD552AZD-17752
iGMDRD886Compound 1541A2
iGMDRD505Pevonedistat3
iGMDRD322FK 8661
iGMDRD512nutlin 33
iGMDRD150RITA2
iGMDRD341Triacsin c3
iGMDRD351GW843682X3
iGMDRD123Isoevodiamine3
iGMDRD901ELCPK3
iGMDRD154NSC237663
iGMDRD474Avrainvillamide3
iGMDRD8024-methylfasudil4
iGMDRD782DC-45-A23
iGMDRD207Capsaicin1
iGMDRD187BRD98763
iGMDRD318PAC-11
iGMDRD399Selumetinib3
iGMDRD100Zebularine1
iGMDRD60Quinoclamine3
iGMDRD451Serdemetan2
iGMDRD151CHM-13
iGMDRD433Lexibulin3
iGMDRD387CHIR-990211
iGMDRD781Sirolimus1
iGMDRD446LY 21832402
iGMDRD61Kinetin riboside4
iGMDRD297Austocystin D2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSP90AB1

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