MCL1


Summary: This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MCL1, BCL2 family apoptosis regulatorMIM:159552Ensembl:ENSG00000143384HGNC:HGNC:6943PA306881q21.2

GO terms in MCL1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFTASGO:0008320protein transmembrane transporter activity
MFIBAGO:0042803protein homodimerization activity
MFIBAGO:0046982protein heterodimerization activity
MFIPIGO:0046982protein heterodimerization activity
MFIPIGO:0051434BH3 domain binding
BPNASGO:0001709cell fate determination
BPIEAGO:0007275multicellular organism development
BPIBAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0008637apoptotic mitochondrial changes
BPIMPGO:0010507negative regulation of autophagy
BPTASGO:0019221cytokine-mediated signaling pathway
BPNASGO:0019725cellular homeostasis
BPIDAGO:0034097response to cytokine
BPIBAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043066negative regulation of apoptotic process
BPIEAGO:0071806protein transmembrane transport
BPIBAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIMPGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIGIGO:1903378positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
BPIMPGO:2000811negative regulation of anoikis
BPIMPGO:2001020regulation of response to DNA damage stimulus
BPIMPGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
BPIBAGO:2001243negative regulation of intrinsic apoptotic signaling pathway
CCIDAGO:0005634nucleus
CCIEAGO:0005654nucleoplasm
CCTASGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCIBAGO:0005741mitochondrial outer membrane
CCTASGO:0005741mitochondrial outer membrane
CCIEAGO:0005759mitochondrial matrix
CCISSGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0016020membrane
CCISSGO:0016020membrane
CCIEAGO:0016021integral component of membrane
CCIDAGO:0097136Bcl-2 family protein complex

Gene expression in normal tissue: MCL1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MCL1


DatabasePathway IDPathway Des.
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
pide2f_pathwayE2F transcription factor network
pidhif1_tfpathwayHIF-1-alpha transcription factor network
pidil6_7pathwayIL6-mediated signaling events
pidp53downstreampathwayDirect p53 effectors
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP254Apoptosis
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3657Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4172PI3K-Akt Signaling Pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD300Tozasertib2
iGMDRD855BRD-K611665971
iGMDRD646PHA-7938871
iGMDRD434BMS-5369243
iGMDRD241Sunitinib1
iGMDRD6AM-5801
iGMDRD68Paclitaxel1
iGMDRD220fumonisin B13
iGMDRD435BI-25362
iGMDRD132(-)-gallocatechin-3-O-gallate1
iGMDRD452PF-5732282
iGMDRD36Phloretin1
iGMDRD859BRD-K851332071
iGMDRD351GW843682X3
iGMDRD456Crizotinib1
iGMDRD798Ceranib-21
iGMDRD404PD3180881
iGMDRD262KU-559331
iGMDRD607Ubistatin B1
iGMDRD533HSCI1_0002701
iGMDRD690PRIMA-1MET1
iGMDRD451Serdemetan1
iGMDRD100Zebularine4
iGMDRD562Navitoclax2
iGMDRD609BRD-K664538931
iGMDRD842BRD-A718831111
iGMDRD577BIX012945
iGMDRD557MGCD-2652
iGMDRD491TAE-6841
iGMDRD255SB2250021
iGMDRD280CYTOCHALASIN B1
iGMDRD235SNS-0321
iGMDRD634SCHEMBL26080411
iGMDRD710BRD-K969701991
iGMDRD201SKI II1
iGMDRD446LY 21832403
iGMDRD528rigosertib1
iGMDRD66Doxorubicin2
iGMDRD718Pyrvinium pamoate4
iGMDRD489GSK-4613641
iGMDRD462OSI-906 (Linsitinib)3
iGMDRD502AZD14801
iGMDRD685AZD45471
iGMDRD857BRD-K705115741
iGMDRD387CHIR-990213
iGMDRD147Prima-11
iGMDRD209BRD63401
iGMDRD526KX2-3911
iGMDRD445Barasertib1
iGMDRD871BRD63681
iGMDRD367Ro 28-16752
iGMDRD286Nsc 6328392
iGMDRD561ABT-2631
iGMDRD329Merck604
iGMDRD213SMR0000686501
iGMDRD197DBeQ1
iGMDRD158NSC1415401
iGMDRD137Indisulam2
iGMDRD156HLI-3731
iGMDRD5Tyrphostin AG 14783
iGMDRD787PF 1841
iGMDRD439KW-24491
iGMDRD123Isoevodiamine4
iGMDRD1029Tubulin inhibitor1
iGMDRD541SNX-2112 (PF-04928473)1
iGMDRD540Alisertib1
iGMDRD165Tretinoin1
iGMDRD38Prochlorperazine1
iGMDRD170Fluvastatin1
iGMDRD532Olaparib1
iGMDRD681SB-7439211
iGMDRD15Tacedinaline1
iGMDRD50Cytarabine1
iGMDRD523Cyanoquinoline, 111
iGMDRD392Masitinib1
iGMDRD747PF-5431
iGMDRD602Foretinib1
iGMDRD356PNU-746543
iGMDRD399Selumetinib4
iGMDRD74Idarubicin1
iGMDRD780PP-301
iGMDRD506Fedratinib1
iGMDRD171Pemetrexed1
iGMDRD294Batimastat1
iGMDRD8012,4-dideoxy-DC-45-A21
iGMDRD848BRD-K284567061
iGMDRD474Avrainvillamide1
iGMDRD92Trifluoperazine1
iGMDRD260FQI-21
iGMDRD760ML2391
iGMDRD488KU-600191
iGMDRD890CR.1.31B1
iGMDRD2PK-111953
iGMDRD21Fluorouracil1
iGMDRD427ABT7373
iGMDRD1Nicotin-Amide1
iGMDRD820anti-tubulin agents1
iGMDRD781Sirolimus6
iGMDRD249CCT0364771
iGMDRD126Tipifarnib3
iGMDRD425ERASTIN1
iGMDRD889Compound 7d-cis5
iGMDRD273Alvocidib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MCL1

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