MCL1
Summary: This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:159552 Ensembl IDEnsembl:ENSG00000143384 HGNC IDHGNC:HGNC:6943 PHARMGKB IDPA30688 Map Location1q21.2 | |||||
GO terms in MCL1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008320 | protein transmembrane transporter activity |
| MF | IBA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0051434 | BH3 domain binding |
Gene expression in normal tissue: MCL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MCL1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pid | e2f_pathway | E2F transcription factor network |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MCL1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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