MCL1
Summary: This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MCL1, BCL2 family apoptosis regulator | MIM:159552 | Ensembl:ENSG00000143384 | HGNC:HGNC:6943 | PA30688 | 1q21.2 |
GO terms in MCL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008320 | protein transmembrane transporter activity |
| MF | IBA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0051434 | BH3 domain binding |
| BP | NAS | GO:0001709 | cell fate determination |
| BP | IEA | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IEA | GO:0008637 | apoptotic mitochondrial changes |
| BP | IMP | GO:0010507 | negative regulation of autophagy |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | NAS | GO:0019725 | cellular homeostasis |
| BP | IDA | GO:0034097 | response to cytokine |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0071806 | protein transmembrane transport |
| BP | IBA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IMP | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IGI | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| BP | IMP | GO:2000811 | negative regulation of anoikis |
| BP | IMP | GO:2001020 | regulation of response to DNA damage stimulus |
| BP | IMP | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IBA | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| CC | IDA | GO:0005634 | nucleus |
| CC | IEA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IBA | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | IEA | GO:0005759 | mitochondrial matrix |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016020 | membrane |
| CC | ISS | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0097136 | Bcl-2 family protein complex |
Gene expression in normal tissue: MCL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MCL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pid | e2f_pathway | E2F transcription factor network |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | p53downstreampathway | Direct p53 effectors |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3614 | Photodynamic therapy-induced HIF-1 survival signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3657 | Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD855 | BRD-K61166597 | 1 |
| iGMDRD646 | PHA-793887 | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD241 | Sunitinib | 1 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD220 | fumonisin B1 | 3 |
| iGMDRD435 | BI-2536 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD452 | PF-573228 | 2 |
| iGMDRD36 | Phloretin | 1 |
| iGMDRD859 | BRD-K85133207 | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD456 | Crizotinib | 1 |
| iGMDRD798 | Ceranib-2 | 1 |
| iGMDRD404 | PD318088 | 1 |
| iGMDRD262 | KU-55933 | 1 |
| iGMDRD607 | Ubistatin B | 1 |
| iGMDRD533 | HSCI1_000270 | 1 |
| iGMDRD690 | PRIMA-1MET | 1 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD609 | BRD-K66453893 | 1 |
| iGMDRD842 | BRD-A71883111 | 1 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD557 | MGCD-265 | 2 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD235 | SNS-032 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD710 | BRD-K96970199 | 1 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD528 | rigosertib | 1 |
| iGMDRD66 | Doxorubicin | 2 |
| iGMDRD718 | Pyrvinium pamoate | 4 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 3 |
| iGMDRD502 | AZD1480 | 1 |
| iGMDRD685 | AZD4547 | 1 |
| iGMDRD857 | BRD-K70511574 | 1 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD209 | BRD6340 | 1 |
| iGMDRD526 | KX2-391 | 1 |
| iGMDRD445 | Barasertib | 1 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD561 | ABT-263 | 1 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD213 | SMR000068650 | 1 |
| iGMDRD197 | DBeQ | 1 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD156 | HLI-373 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD787 | PF 184 | 1 |
| iGMDRD439 | KW-2449 | 1 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD1029 | Tubulin inhibitor | 1 |
| iGMDRD541 | SNX-2112 (PF-04928473) | 1 |
| iGMDRD540 | Alisertib | 1 |
| iGMDRD165 | Tretinoin | 1 |
| iGMDRD38 | Prochlorperazine | 1 |
| iGMDRD170 | Fluvastatin | 1 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD681 | SB-743921 | 1 |
| iGMDRD15 | Tacedinaline | 1 |
| iGMDRD50 | Cytarabine | 1 |
| iGMDRD523 | Cyanoquinoline, 11 | 1 |
| iGMDRD392 | Masitinib | 1 |
| iGMDRD747 | PF-543 | 1 |
| iGMDRD602 | Foretinib | 1 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD399 | Selumetinib | 4 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 1 |
| iGMDRD848 | BRD-K28456706 | 1 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD92 | Trifluoperazine | 1 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD760 | ML239 | 1 |
| iGMDRD488 | KU-60019 | 1 |
| iGMDRD890 | CR.1.31B | 1 |
| iGMDRD2 | PK-11195 | 3 |
| iGMDRD21 | Fluorouracil | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD1 | Nicotin-Amide | 1 |
| iGMDRD820 | anti-tubulin agents | 1 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD249 | CCT036477 | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD273 | Alvocidib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MCL1
CLASSFICATION
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