ADGRB1
Summary: Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| adhesion G protein-coupled receptor B1 | MIM:602682 | Ensembl:ENSG00000181790 | HGNC:HGNC:943 | PA25247 | 8q24.3 |
GO terms in ADGRB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0001530 | lipopolysaccharide binding |
| MF | ISS | GO:0001786 | phosphatidylserine binding |
| MF | IBA | GO:0001965 | G-protein alpha-subunit binding |
| MF | IBA | GO:0004930 | G-protein coupled receptor activity |
| MF | IDA | GO:0004930 | G-protein coupled receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0030165 | PDZ domain binding |
| CC | ISS | GO:0001891 | phagocytic cup |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005911 | cell-cell junction |
| CC | ISS | GO:0005925 | focal adhesion |
| CC | IBA | GO:0014069 | postsynaptic density |
| CC | ISS | GO:0014069 | postsynaptic density |
| CC | TAS | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0030425 | dendrite |
| CC | ISS | GO:0030425 | dendrite |
| CC | IEA | GO:0043197 | dendritic spine |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | ISS | GO:0006910 | phagocytosis, recognition |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007409 | axonogenesis |
| BP | TAS | GO:0007422 | peripheral nervous system development |
| BP | IEA | GO:0007517 | muscle organ development |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0010596 | negative regulation of endothelial cell migration |
| BP | IDA | GO:0016525 | negative regulation of angiogenesis |
| BP | ISS | GO:0031397 | negative regulation of protein ubiquitination |
| BP | ISS | GO:0042177 | negative regulation of protein catabolic process |
| BP | IMP | GO:0043277 | apoptotic cell clearance |
| BP | IBA | GO:0043652 | engulfment of apoptotic cell |
| BP | IMP | GO:0043652 | engulfment of apoptotic cell |
| BP | ISS | GO:0043652 | engulfment of apoptotic cell |
| BP | IEA | GO:0045087 | innate immune response |
| BP | ISS | GO:0048167 | regulation of synaptic plasticity |
| BP | ISS | GO:0050829 | defense response to Gram-negative bacterium |
| BP | IEA | GO:0051965 | positive regulation of synapse assembly |
| BP | ISS | GO:1901741 | positive regulation of myoblast fusion |
| BP | IMP | GO:1903428 | positive regulation of reactive oxygen species biosynthetic process |
Gene expression in normal tissue: ADGRB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADGRB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD441 | TW 37 | 4 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD137 | Indisulam | 11 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD405 | PIK-75 | 4 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD499 | PDMP | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADGRB1
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