ADGRB1
Summary: Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602682 Ensembl IDEnsembl:ENSG00000181790 HGNC IDHGNC:HGNC:943 PHARMGKB IDPA25247 Map Location8q24.3 | |||||
GO terms in ADGRB1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0001530 | lipopolysaccharide binding |
| MF | ISS | GO:0001786 | phosphatidylserine binding |
| MF | IBA | GO:0001965 | G-protein alpha-subunit binding |
| MF | IBA | GO:0004930 | G-protein coupled receptor activity |
| MF | IDA | GO:0004930 | G-protein coupled receptor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: ADGRB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADGRB1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADGRB1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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