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iGMDRD211

Canonical SMILES: COC(=O)C1CC2=C(C(N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24

InChI: InChI=1S/C23H21ClN2O5/c1-30-22(28)14-9-7-13(8-10-14)21-20-16(15-5-3-4-6-17(15)25-20)11-18(23(29)31-2)26(21)19(27)12-24/h3-10,18,21,25H,11-12H2,1-2H3/t18-,21+/m1/s1

InChI Key: TXJZRSRTYPUYRW-NQIIRXRSSA-N

Standard Name	Pubchem CID	Drug Status	Drug Type
(1S,3R)-RSL3	1750830	Alone	Small Molecule

Drug Targets:

GPX4

Drug Pathways:

Ferroptosis

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3696	ITGB8	3
27125	AFF4	2
8999	CDKL2	3
8019	BRD3	2
10903	MTMR11	2
79848	CSPP1	2
79054	TRPM8	2
10641	NPRL2	3
10987	COPS5	3
132	ADK	1
4926	NUMA1	2
8929	PHOX2B	3
10806	SDCCAG8	2
23513	SCRIB	1
2200	FBN1	6
4303	FOXO4	2
57679	ALS2	3
347365	ITIH6	2
3845	KRAS	1
6563	SLC14A1	2
80070	ADAMTS20	1
8573	CASK	2
3939	LDHA	2
53616	ADAM22	3
4312	MMP1	2
9475	ROCK2	3
10395	DLC1	1
5241	PGR	3
79820	CATSPERB	3
9530	BAG4	2
51684	SUFU	3
23235	SIK2	5
9891	NUAK1	3
22853	LMTK2	2
7253	TSHR	2
8749	ADAM18	3
341676	NEK5	2
57172	CAMK1G	3
140469	MYO3B	1
7048	TGFBR2	1
2249	FGF4	2
577	ADGRB3	3
1387	CREBBP	1
4881	NPR1	3
10013	HDAC6	2
5579	PRKCB	1
2984	GUCY2C	3
31	ACACA	1
51755	CDK12	3
1111	CHEK1	3
2977	GUCY1A2	3
10438	C1D	3
139378	ADGRG4	3
7158	TP53BP1	2
55294	FBXW7	3
2033	EP300	3
8030	CCDC6	3
641	BLM	2
4361	MRE11	3
55728	N4BP2	2
57670	KIAA1549	2
22861	NLRP1	3
2115	ETV1	2
5081	PAX7	3
5743	PTGS2	3
342977	NANOS3	6
152137	CCDC50	5
256646	NUTM1	1
131096	KCNH8	3
9693	RAPGEF2	3
8549	LGR5	3
5613	PRKX	2
9175	MAP3K13	2
8313	AXIN2	4
51343	FZR1	2
80129	CCDC170	2
4982	TNFRSF11B	2
2045	EPHA7	3
23405	DICER1	3
171019	ADAMTS19	3
54899	PXK	2
440730	TRIM67	2
9472	AKAP6	1
2778	GNAS	3
3667	IRS1	4
80243	PREX2	3
8148	TAF15	3
28996	HIPK2	3
575	ADGRB1	3
53942	CNTN5	5
4087	SMAD2	2
84433	CARD11	3
1123	CHN1	2
5450	POU2AF1	4
2066	ERBB4	2
9319	TRIP13	3
7184	HSP90B1	2
5129	CDK18	1
58508	KMT2C	2
7157	TP53	2
6794	STK11	3
836	CASP3	2
6184	RPN1	3
2133	EXT3	3
8833	GMPS	6
3187	HNRNPH1	2
7175	TPR	2
23365	ARHGEF12	3
84181	CHD6	2
57578	UNC79	1
4026	LPP	3
7994	KAT6A	1
23469	PHF3	2
6654	SOS1	2
672	BRCA1	2
256536	TCERG1L	3
9448	MAP4K4	2
546	ATRX	1
54756	IL17RD	4
5069	PAPPA	4
10769	PLK2	3
30827	CXXC1	3
56997	COQ8A	3
57144	PAK5	3
602	BCL3	1
2187	FANCB	3
50615	IL21R	3
3720	JARID2	3
1687	GSDME	2
8202	NCOA3	3
4293	MAP3K9	2
10565	ARFGEF1	4
675	BRCA2	3
3458	IFNG	3
744	MPPED2	3
1956	EGFR	2
8445	DYRK2	2
841	CASP8	2
11064	CNTRL	4
5599	MAPK8	3
8021	NUP214	3
10461	MERTK	2
7297	TYK2	3
4684	NCAM1	3
26278	SACS	3
5462	POU5F1B	2
51701	NLK	2
6446	SGK1	2
5592	PRKG1	3
7917	BAG6	2
10000	AKT3	1
91754	NEK9	3
6872	TAF1	6
7153	TOP2A	2
1213	CLTC	6
23532	PRAME	3
4863	NPAT	3
8924	HERC2	3
339345	NANOS2	1
89795	NAV3	2
65268	WNK2	1
867	CBL	3
5205	ATP8B1	2
460	ASTN1	3
9509	ADAMTS2	3
8621	CDK13	3
5563	PRKAA2	3
8312	AXIN1	1
10752	CHL1	2
5728	PTEN	1
57521	RPTOR	2
22883	CLSTN1	2
667	DST	5
115701	ALPK2	2
140803	TRPM6	3
85409	NKD2	6
658	BMPR1B	3
1676	DFFA	3
7273	TTN	3
23389	MED13L	2
6787	NEK4	2
54904	NSD3	3
8648	NCOA1	2
79012	CAMKV	2
9372	ZFYVE9	3
54861	SNRK	2
5532	PPP3CB	4
286151	FBXO43	3
2072	ERCC4	3
344905	ATP13A5	2
7248	TSC1	3
2869	GRK5	2
317	APAF1	3
9021	SOCS3	2
10111	RAD50	2
53353	LRP1B	6
9201	DCLK1	3
5587	PRKD1	2
1975	EIF4B	3
2157	F8	1
7227	TRPS1	1
3709	ITPR2	9
6778	STAT6	3
2719	GPC3	2
5932	RBBP8	3
4261	CIITA	3
23250	ATP11A	3
5087	PBX1	2
3815	KIT	3
9894	TELO2	3
2903	GRIN2A	3
5925	RB1	1
8661	EIF3A	3
8841	HDAC3	3
79728	PALB2	5
4915	NTRK2	1
142	PARP1	2
23072	HECW1	6
55422	ZNF331	2
4763	NF1	3
57697	FANCM	2
10891	PPARGC1A	1
2044	EPHA5	3
4629	MYH11	6
1608	DGKG	2
1499	CTNNB1	3
2444	FRK	1
27151	CPAMD8	2
4916	NTRK3	4

Gene in drug-gene network: Network Plot

Models in (1S,3R)-RSL3

SITE

DATATYPES

CLASSFICATION

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