COQ8A
Summary: This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namecoenzyme Q8A OMIM IDMIM:606980 Ensembl IDEnsembl:ENSG00000163050 HGNC IDHGNC:HGNC:16812 PHARMGKB IDPA25999 Map Location1q42.13 | |||||
GO terms in COQ8A
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0031314 | extrinsic component of mitochondrial inner membrane |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006744 | ubiquinone biosynthetic process |
Gene expression in normal tissue: COQ8A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in COQ8A
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in COQ8A
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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