COQ8A


Summary: This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
coenzyme Q8AMIM:606980Ensembl:ENSG00000163050HGNC:HGNC:16812PA259991q42.13

GO terms in COQ8A


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005739mitochondrion
CCIDAGO:0005739mitochondrion
CCIEAGO:0016021integral component of membrane
CCIBAGO:0031314extrinsic component of mitochondrial inner membrane
BPIDAGO:0006468protein phosphorylation
BPIBAGO:0006744ubiquinone biosynthetic process
BPIEAGO:0006744ubiquinone biosynthetic process
BPIMPGO:0006744ubiquinone biosynthetic process
BPIDAGO:0016310phosphorylation
MFIDAGO:0004672protein kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0016301kinase activity
MFIDAGO:0016301kinase activity
MFIDAGO:0043531ADP binding

Gene expression in normal tissue: COQ8A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in COQ8A


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD76Simvastatin3
iGMDRD512nutlin 33
iGMDRD150RITA2
iGMDRD116CD4375
iGMDRD144NSC953976
iGMDRD405PIK-751
iGMDRD152179324-69-73
iGMDRD193Fqi13
iGMDRD211(1S,3R)-RSL33
iGMDRD123Isoevodiamine3
iGMDRD883CIL55A4
iGMDRD945ML2146
iGMDRD251ML1623
iGMDRD138PX 126
iGMDRD134Sorafenib1
iGMDRD289Parthenolide3
iGMDRD705Nakiterpiosin3
iGMDRD782DC-45-A21
iGMDRD871BRD63682
iGMDRD100Zebularine2
iGMDRD286Nsc 6328393
iGMDRD188Piperlongumine6
iGMDRD887Compound 23 citrate3
iGMDRD329Merck603
iGMDRD577BIX012946
iGMDRD506Fedratinib6
iGMDRD366PI-1031
iGMDRD886Compound 1541A3
iGMDRD64Parbendazole3
iGMDRD60Quinoclamine3
iGMDRD246NPC263

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COQ8A

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