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iGMDRD152

Canonical SMILES: B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

InChI: InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

InChI Key: GXJABQQUPOEUTA-RDJZCZTQSA-N

Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
179324-69-7	CHEMBL325041	387447	D03150	DB00188	Alone	DAP001318	Small Molecule

Drug Class:

Acids Acids, Noncarboxylic Antineoplastic Agents Antineoplastic and Immunomodulating Agents Boron Compounds Boronic Acids Cardiotoxic antineoplastic agents Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (moderate)Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (moderate)Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak)Cytochrome P-450 Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Hypotensive Agents Immunosuppressive Agents Myelosuppressive Agents Potential QTc-Prolonging Agents Proteasome Inhibitors Pyrazines QTc Prolonging Agents

Drug Targets:

Proteasome PSMB5 (P28074)PSMB1 (P20618)PSMB2 PSMD1;PSMD2

Drug Pathways:

Proteasome Protein stability and degradation

Drug Synonyms:

Bortezomib (JAN/USAN/INN)Velcade (TN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
64901	RANBP17	3
7074	TIAM1	4
7535	ZAP70	4
7837	PXDN	2
79054	TRPM8	4
23085	ERC1	3
7128	TNFAIP3	4
8444	DYRK3	1
10987	COPS5	3
8476	CDC42BPA	2
4926	NUMA1	2
2986	GUCY2F	4
2048	EPHB2	4
2956	MSH6	1
2200	FBN1	4
4303	FOXO4	3
9706	ULK2	1
3845	KRAS	1
51347	TAOK3	1
8289	ARID1A	2
80070	ADAMTS20	1
84700	MYO18B	3
2475	MTOR	1
9475	ROCK2	4
6597	SMARCA4	5
2176	FANCC	2
11160	ERLIN2	2
5133	PDCD1	5
56776	FMN2	4
64783	RBM15	7
1607	DGKB	6
23213	SULF1	3
9641	IKBKE	6
3066	HDAC2	2
22853	LMTK2	2
27	ABL2	3
22821	RASA3	3
7048	TGFBR2	2
79934	COQ8B	4
54822	TRPM7	3
1893	ECM1	3
10454	TAB1	2
2043	EPHA4	2
3727	JUND	3
5579	PRKCB	1
10178	TENM1	5
9048	ARTN	1
9411	ARHGAP29	4
85021	REPS1	4
3604	TNFRSF9	1
8295	TRRAP	2
26576	SRPK3	2
2977	GUCY1A2	4
27148	STK36	3
7373	COL14A1	3
5314	PKHD1	5
139378	ADGRG4	6
7158	TP53BP1	1
89910	UBE3B	3
8784	TNFRSF18	4
641	BLM	3
5914	RARA	2
4595	MUTYH	1
57670	KIAA1549	2
4610	MYCL	3
4301	AFDN	3
816	CAMK2B	2
84033	OBSCN	1
256646	NUTM1	3
2268	FGR	3
8600	TNFSF11	5
2051	EPHB6	1
9693	RAPGEF2	2
57787	MARK4	3
1586	CYP17A1	5
6256	RXRA	3
166614	DCLK2	3
3645	INSRR	3
22984	PDCD11	1
9175	MAP3K13	3
200576	PIKFYVE	2
6733	SRPK2	2
6091	ROBO1	1
2042	EPHA3	1
51343	FZR1	1
10188	TNK2	2
2210	FCGR1B	1
2736	GLI2	2
695	BTK	6
4739	NEDD9	3
2045	EPHA7	6
23405	DICER1	3
238	ALK	1
7428	VHL	1
2064	ERBB2	7
26750	RPS6KC1	2
79971	WLS	5
9131	AIFM1	6
5580	PRKCD	3
6416	MAP2K4	3
9759	HDAC4	1
7525	YES1	3
5286	PIK3C2A	2
65987	KCTD14	3
6709	SPTAN1	1
1973	EIF4A1	3
2068	ERCC2	2
80312	TET1	5
5568	PRKACG	2
9472	AKAP6	2
638	BIK	3
130497	OSR1	3
80243	PREX2	2
2580	GAK	5
1009	CDH11	4
139285	AMER1	1
575	ADGRB1	3
53942	CNTN5	5
3397	ID1	1
5924	RASGRF2	4
54986	ULK4	2
1496	CTNNA2	7
2272	FHIT	1
5327	PLAT	3
5863	RGL2	1
10290	SPEG	1
2201	FBN2	1
1029	CDKN2A	2
10062	NR1H3	3
9794	MAML1	1
959	CD40LG	3
27347	STK39	2
58508	KMT2C	2
7157	TP53	1
6092	ROBO2	5
6794	STK11	12
57194	ATP10A	3
6655	SOS2	1
4857	NOVA1	2
25836	NIPBL	1
10114	HIPK3	3
93210	PGAP3	2
114788	CSMD3	5
3000	GUCY2D	2
2263	FGFR2	2
2133	EXT3	6
1019	CDK4	1
7409	VAV1	2
84075	FSCB	2
85481	PSKH2	3
8833	GMPS	1
8874	ARHGEF7	2
5597	MAPK6	2
10516	FBLN5	4
1102	RCBTB2	4
7422	VEGFA	1
7038	TG	1
8660	IRS2	6
57188	ADAMTSL3	2
3187	HNRNPH1	4
652	BMP4	2
162979	ZNF296	2
1441	CSF3R	4
80205	CHD9	1
8831	SYNGAP1	6
7994	KAT6A	1
23469	PHF3	3
6654	SOS1	1
672	BRCA1	1
2060	EPS15	4
1616	DAXX	1
5727	PTCH1	6
285220	EPHA6	2
23678	SGK3	6
2047	EPHB1	1
7786	MAP3K12	5
1978	EIF4EBP1	1
56997	COQ8A	3
4214	MAP3K1	1
3702	ITK	5
3239	HOXD13	6
5034	P4HB	3
6391	SDHC	3
64919	BCL11B	7
4803	NGF	3
8445	DYRK2	3
157680	VPS13B	4
841	CASP8	4
64750	SMURF2	1
2624	GATA2	1
5789	PTPRD	3
1459	CSNK2A2	2
10461	MERTK	1
8682	PEA15	1
4684	NCAM1	3
26278	SACS	4
51701	NLK	4
5747	PTK2	1
5156	PDGFRA	4
3635	INPP5D	1
8900	CCNA1	4
5187	PER1	3
7015	TERT	3
673	BRAF	1
57082	KNL1	3
84630	TTBK1	4
1981	EIF4G1	1
84879	MFSD2A	1
1769	DNAH8	4
22976	PAXIP1	6
23532	PRAME	8
5598	MAPK7	1
2867	FFAR2	3
57507	ZNF608	1
7468	NSD2	4
5128	CDK17	3
9113	LATS1	1
9064	MAP3K6	4
5294	PIK3CG	1
1024	CDK8	3
9451	EIF2AK3	3
4853	NOTCH2	1
9509	ADAMTS2	2
4791	NFKB2	2
23742	NPAP1	5
1806	DPYD	3
57521	RPTOR	2
51330	TNFRSF12A	3
8888	MCM3AP	6
55120	FANCL	6
115701	ALPK2	6
5594	MAPK1	3
140803	TRPM6	1
658	BMPR1B	6
91807	MYLK3	5
5582	PRKCG	4
6789	STK4	7
7454	WAS	1
85415	RHPN2	2
8667	EIF3H	2
79012	CAMKV	2
7150	TOP1	2
10243	GPHN	6
84930	MASTL	1
1662	DDX10	2
344905	ATP13A5	2
5588	PRKCQ	3
4297	KMT2A	3
2690	GHR	1
2041	EPHA1	2
2317	FLNB	1
8031	NCOA4	5
1789	DNMT3B	2
54101	RIPK4	3
6093	ROCK1	3
3624	INHBA	1
3579	CXCR2	3
5111	PCNA	1
10734	STAG3	1
2321	FLT1	2
1975	EIF4B	6
57448	BIRC6	2
22982	DIP2C	5
7099	TLR4	4
7227	TRPS1	9
5506	PPP1R3A	2
6778	STAT6	3
57118	CAMK1D	1
8899	PRPF4B	3
1030	CDKN2B	1
150094	SIK1	3
51562	MBIP	3
5932	RBBP8	5
330	BIRC3	3
201163	FLCN	1
444	ASPH	3
11076	TPPP	1
7046	TGFBR1	3
80781	COL18A1	3
8536	CAMK1	6
2122	MECOM	2
51167	CYB5R4	2
3815	KIT	4
6653	SORL1	5
4974	OMG	2
5925	RB1	4
5584	PRKCI	3
63923	TNN	1
2065	ERBB3	3
2074	ERCC6	1
3131	HLF	6
25	ABL1	2
862	RUNX1T1	2
3691	ITGB4	3
7508	XPC	3
7040	TGFB1	1
55959	SULF2	1
23092	ARHGAP26	4
142	PARP1	1
2261	FGFR3	4
23072	HECW1	5
79577	CDC73	3
84197	POMK	1
84446	BRSK1	3
55422	ZNF331	1
1013	CDH15	1
156	GRK2	3
4763	NF1	1
8814	CDKL1	3
55791	LRIF1	5
4613	MYCN	3
63893	UBE2O	2
494551	WEE2	1
1840	DTX1	1
4591	TRIM37	3
10891	PPARGC1A	4
5288	PIK3C2G	1
57096	RPGRIP1	2
2044	EPHA5	5
4629	MYH11	4
30811	HUNK	1
4193	MDM2	1
6868	ADAM17	1
23112	TNRC6B	1
27255	CNTN6	1
27151	CPAMD8	4
3440	IFNA2	1
4916	NTRK3	4
167359	NIM1K	3
5970	RELA	1
5590	PRKCZ	1

Gene in drug-gene network: Network Plot

Models in 179324-69-7

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