CDKL1
Summary: This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase like 1 | MIM:603441 | Ensembl:ENSG00000100490 | HGNC:HGNC:1781 | PA26317 | 14q21.3 |
GO terms in CDKL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007507 | heart development |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| BP | ISS | GO:1902017 | regulation of cilium assembly |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0035869 | ciliary transition zone |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: CDKL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDKL1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD889 | Compound 7d-cis | 6 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD888 | Compound 44 | 6 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD872 | BRD7137 | 9 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDKL1
CLASSFICATION
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