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iGMDRD322

Canonical SMILES: C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3

InChI: InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+

InChI Key: KPBNHDGDUADAGP-VAWYXSNFSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
FK 866	CHEMBL566757	6914660	DB12731	Alone	Small Molecule

Drug Class:

Acids, Acyclic Acrylates Amides Carboxylic Acids Heterocyclic Compounds Heterocyclic Compounds, 1-Ring

Drug Targets:

NAMPT (P43490)

Drug Pathways:

Metabolism

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	3
3696	ITGB8	1
64901	RANBP17	3
10903	MTMR11	2
79054	TRPM8	2
1464	CSPG4	2
8444	DYRK3	3
10987	COPS5	3
132	ADK	2
114801	TMEM200A	3
4168	MCF2	3
4303	FOXO4	2
57679	ALS2	3
3708	ITPR1	1
1588	CYP19A1	2
57554	LRRC7	3
817	CAMK2D	3
7272	TTK	4
2100	ESR2	3
8289	ARID1A	3
701	BUB1B	1
5934	RBL2	3
3431	SP110	3
6938	TCF12	4
7850	IL1R2	3
3326	HSP90AB1	1
11160	ERLIN2	2
5241	PGR	1
5133	PDCD1	3
7444	VRK2	5
7942	TFEB	1
390502	SERPINA2	2
53944	CSNK1G1	3
56776	FMN2	1
5079	PAX5	2
64783	RBM15	2
10892	MALT1	2
23235	SIK2	4
1272	CNTN1	1
3320	HSP90AA1	3
3066	HDAC2	5
22821	RASA3	3
7080	NKX2-1	10
577	ADGRB3	2
5756	TWF1	2
5788	PTPRC	2
23225	NUP210	1
2313	FLI1	6
5579	PRKCB	2
11200	CHEK2	1
1602	DACH1	3
10178	TENM1	2
9411	ARHGAP29	2
3604	TNFRSF9	2
10438	C1D	2
4851	NOTCH1	1
5314	PKHD1	3
641	BLM	3
1021	CDK6	2
4595	MUTYH	3
55728	N4BP2	2
25925	ZNF521	3
54477	PLEKHA5	4
55819	RNF130	3
5607	MAP2K5	2
256646	NUTM1	5
122011	CSNK1A1L	2
2051	EPHB6	4
9693	RAPGEF2	5
288	ANK3	1
32	ACACB	3
3556	IL1RAP	2
22806	IKZF3	2
7416	VDAC1	3
22984	PDCD11	3
6733	SRPK2	3
2042	EPHA3	2
4792	NFKBIA	10
11169	WDHD1	3
29904	EEF2K	3
83990	BRIP1	2
3688	ITGB1	3
284217	LAMA1	2
1143	CHRNB4	2
5898	RALA	3
55681	SCYL2	5
2045	EPHA7	1
23405	DICER1	3
171019	ADAMTS19	3
375449	MAST4	3
2064	ERBB2	1
85443	DCLK3	5
55361	PI4K2A	3
7486	WRN	6
1452	CSNK1A1	1
8714	ABCC3	3
2068	ERCC2	2
5568	PRKACG	2
659	BMPR2	5
6098	ROS1	1
9472	AKAP6	7
8945	BTRC	2
2580	GAK	6
1009	CDH11	1
139285	AMER1	3
575	ADGRB1	1
3397	ID1	3
5924	RASGRF2	3
2734	GLG1	3
6792	CDKL5	3
7010	TEK	6
23152	CIC	3
2050	EPHB4	3
2066	ERBB4	4
10290	SPEG	3
10062	NR1H3	2
57523	NYNRIN	2
58508	KMT2C	2
7157	TP53	4
6092	ROBO2	4
6794	STK11	4
7869	SEMA3B	5
8218	CLTCL1	2
114788	CSMD3	5
8874	ARHGEF7	3
1555	CYP2B6	2
51086	TNNI3K	3
7175	TPR	3
80205	CHD9	3
23365	ARHGEF12	1
57578	UNC79	5
10499	NCOA2	3
23269	MGA	1
51284	TLR7	1
170692	ADAMTS18	1
6654	SOS1	10
2668	GDNF	1
78989	COLEC11	3
5727	PTCH1	2
51366	UBR5	3
3417	IDH1	1
5069	PAPPA	3
57144	PAK5	2
340533	NEXMIF	2
8216	LZTR1	2
3702	ITK	2
8731	RNMT	1
9972	NUP153	2
5290	PIK3CA	2
3720	JARID2	1
1514	CTSL	2
1000	CDH2	2
26524	LATS2	2
2318	FLNC	3
10565	ARFGEF1	2
57154	SMURF1	3
7075	TIE1	1
1956	EGFR	6
8445	DYRK2	1
157680	VPS13B	2
4318	MMP9	3
841	CASP8	2
3065	HDAC1	3
64333	ARHGAP9	3
5789	PTPRD	1
10461	MERTK	4
100130933	SMIM6	3
26278	SACS	2
51265	CDKL3	2
6446	SGK1	3
5156	PDGFRA	3
5187	PER1	3
375056	MIA3	2
9159	PCSK7	2
27330	RPS6KA6	3
84630	TTBK1	2
1981	EIF4G1	5
84879	MFSD2A	3
1769	DNAH8	1
22976	PAXIP1	2
4863	NPAT	3
83452	RAB33B	3
5598	MAPK7	2
8924	HERC2	6
339345	NANOS2	3
120892	LRRK2	4
11126	CD160	2
57507	ZNF608	3
5128	CDK17	1
8626	TP63	5
9113	LATS1	3
8178	ELL	3
9451	EIF2AK3	2
9843	HEPH	1
5563	PRKAA2	2
8312	AXIN1	5
23542	MAPK8IP2	2
2324	FLT4	3
1950	EGF	2
2264	FGFR4	2
177	AGER	3
8301	PICALM	6
1018	CDK3	3
79834	PEAK1	2
203447	NRK	3
29959	NRBP1	2
8648	NCOA1	5
387	RHOA	4
9372	ZFYVE9	4
54861	SNRK	2
84930	MASTL	2
8805	TRIM24	5
2072	ERCC4	2
10076	PTPRU	1
558	AXL	3
332	BIRC5	2
83417	FCRL4	3
57680	CHD8	2
5581	PRKCE	2
5923	RASGRF1	1
2317	FLNB	1
53353	LRP1B	3
5609	MAP2K7	3
5587	PRKD1	5
10734	STAG3	3
5589	PRKCSH	1
5170	PDPK1	1
7099	TLR4	3
2157	F8	2
5506	PPP1R3A	2
6778	STAT6	5
57118	CAMK1D	3
51562	MBIP	9
6777	STAT5B	2
3552	IL1A	2
330	BIRC3	3
7112	TMPO	3
84072	HORMAD1	1
170685	NUDT10	3
1760	DMPK	2
3815	KIT	3
4974	OMG	2
5925	RB1	8
63923	TNN	3
3691	ITGB4	2
4615	MYD88	3
255239	ANKK1	2
5586	PKN2	6
10494	STK25	6
142	PARP1	6
2261	FGFR3	2
2073	ERCC5	3
4763	NF1	1
8814	CDKL1	3
440270	GOLGA8B	3
94	ACVRL1	1
2044	EPHA5	6
4629	MYH11	3
10048	RANBP9	3
7294	TXK	2
6868	ADAM17	1
23112	TNRC6B	5
27255	CNTN6	4
57699	CPNE5	1
2444	FRK	1
56155	TEX14	4
5624	PROC	1
5590	PRKCZ	4

Gene in drug-gene network: Network Plot

Models in FK 866

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.