NCOA1
Summary: The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear receptor coactivator 1 | MIM:602691 | Ensembl:ENSG00000084676 | HGNC:HGNC:7668 | PA31470 | 2p23.3 |
GO terms in NCOA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000435 | positive regulation of transcription from RNA polymerase II promoter by galactose |
| BP | IEA | GO:0002155 | regulation of thyroid hormone mediated signaling pathway |
| BP | IDA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0015721 | bile acid and bile salt transport |
| BP | TAS | GO:0019216 | regulation of lipid metabolic process |
| BP | NAS | GO:0030521 | androgen receptor signaling pathway |
| BP | IBA | GO:0032870 | cellular response to hormone stimulus |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043967 | histone H4 acetylation |
| BP | IEA | GO:0045666 | positive regulation of neuron differentiation |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | NAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | NAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0060713 | labyrinthine layer morphogenesis |
| BP | IEA | GO:1904017 | cellular response to Thyroglobulin triiodothyronine |
| BP | IEA | GO:2001038 | regulation of cellular response to drug |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IMP | GO:0032991 | protein-containing complex |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | NAS | GO:0003713 | transcription coactivator activity |
| MF | IEA | GO:0004402 | histone acetyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016922 | nuclear receptor binding |
| MF | IPI | GO:0016922 | nuclear receptor binding |
| MF | IPI | GO:0017162 | aryl hydrocarbon receptor binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0030331 | estrogen receptor binding |
| MF | IBA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IDA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IBA | GO:0035257 | nuclear hormone receptor binding |
| MF | IDA | GO:0035257 | nuclear hormone receptor binding |
| MF | IEA | GO:0046983 | protein dimerization activity |
| MF | IPI | GO:0047485 | protein N-terminus binding |
| MF | NAS | GO:0050681 | androgen receptor binding |
Gene expression in normal tissue: NCOA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NCOA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2875 | Constitutive Androstane Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | erb_genomic_pathway | Validated nuclear estrogen receptor beta network |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | rxr_vdr_pathway | RXR and RAR heterodimerization with other nuclear receptor |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | rarrxrpathway | nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1368082 | RORA activates gene expression |
| reactome | R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian gene expression |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-159418 | Recycling of bile acids and salts |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-192105 | Synthesis of bile acids and bile salts |
| reactome | R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| reactome | R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| reactome | R-HSA-194068 | Bile acid and bile salt metabolism |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211897 | Cytochrome P450 - arranged by substrate type |
| reactome | R-HSA-211945 | Phase I - Functionalization of compounds |
| reactome | R-HSA-211976 | Endogenous sterols |
| reactome | R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis |
| reactome | R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3214847 | HATs acetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD512 | nutlin 3 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NCOA1
CLASSFICATION
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