NCOA1
Summary: The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602691 Ensembl IDEnsembl:ENSG00000084676 HGNC IDHGNC:HGNC:7668 PHARMGKB IDPA31470 Map Location2p23.3 | |||||
GO terms in NCOA1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000435 | positive regulation of transcription from RNA polymerase II promoter by galactose |
| BP | IEA | GO:0002155 | regulation of thyroid hormone mediated signaling pathway |
| BP | IDA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0015721 | bile acid and bile salt transport |
| BP | TAS | GO:0019216 | regulation of lipid metabolic process |
| BP | NAS | GO:0030521 | androgen receptor signaling pathway |
Gene expression in normal tissue: NCOA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NCOA1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NCOA1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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