NCOA1


Summary: The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nuclear receptor coactivator 1MIM:602691Ensembl:ENSG00000084676HGNC:HGNC:7668PA314702p23.3

GO terms in NCOA1


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000435positive regulation of transcription from RNA polymerase II promoter by galactose
BPIEAGO:0002155regulation of thyroid hormone mediated signaling pathway
BPIDAGO:0006351transcription, DNA-templated
BPTASGO:0015721bile acid and bile salt transport
BPTASGO:0019216regulation of lipid metabolic process
BPNASGO:0030521androgen receptor signaling pathway
BPIBAGO:0032870cellular response to hormone stimulus
BPIEAGO:0043065positive regulation of apoptotic process
BPIEAGO:0043967histone H4 acetylation
BPIEAGO:0045666positive regulation of neuron differentiation
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPNASGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPNASGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0060713labyrinthine layer morphogenesis
BPIEAGO:1904017cellular response to Thyroglobulin triiodothyronine
BPIEAGO:2001038regulation of cellular response to drug
CCIDAGO:0000790nuclear chromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIMPGO:0032991protein-containing complex
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFIEAGO:0003682chromatin binding
MFIDAGO:0003713transcription coactivator activity
MFNASGO:0003713transcription coactivator activity
MFIEAGO:0004402histone acetyltransferase activity
MFIPIGO:0005515protein binding
MFIBAGO:0016922nuclear receptor binding
MFIPIGO:0016922nuclear receptor binding
MFIPIGO:0017162aryl hydrocarbon receptor binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0030331estrogen receptor binding
MFIBAGO:0030374nuclear receptor transcription coactivator activity
MFIDAGO:0030374nuclear receptor transcription coactivator activity
MFIBAGO:0035257nuclear hormone receptor binding
MFIDAGO:0035257nuclear hormone receptor binding
MFIEAGO:0046983protein dimerization activity
MFIPIGO:0047485protein N-terminus binding
MFNASGO:0050681androgen receptor binding

Gene expression in normal tissue: NCOA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NCOA1


DatabasePathway IDPathway Des.
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP236Adipogenesis
wikipathwaysWP2593JAK-STAT
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2875Constitutive Androstane Receptor Pathway
wikipathwaysWP2876Pregnane X Receptor pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP364IL-6 signaling pathway
wikipathwaysWP4010Liver steatosis AOP
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_IL6IL6
netpathPathway_LeptinLeptin
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
pidar_tf_pathwayRegulation of Androgen receptor activity
pidera_genomic_pathwayValidated nuclear estrogen receptor alpha network
piderb_genomic_pathwayValidated nuclear estrogen receptor beta network
pidhes_heypathwayNotch-mediated HES/HEY network
pidhif1_tfpathwayHIF-1-alpha transcription factor network
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidretinoic_acid_pathwayRetinoic acid receptors-mediated signaling
pidrxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartararrxrpathwaynuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1368082RORA activates gene expression
reactomeR-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expression
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1592230Mitochondrial biogenesis
reactomeR-HSA-159418Recycling of bile acids and salts
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-192105Synthesis of bile acids and bile salts
reactomeR-HSA-193368Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
reactomeR-HSA-193807Synthesis of bile acids and bile salts via 27-hydroxycholesterol
reactomeR-HSA-194068Bile acid and bile salt metabolism
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-211897Cytochrome P450 - arranged by substrate type
reactomeR-HSA-211945Phase I - Functionalization of compounds
reactomeR-HSA-211976Endogenous sterols
reactomeR-HSA-2151201Transcriptional activation of mitochondrial biogenesis
reactomeR-HSA-2426168Activation of gene expression by SREBF (SREBP)
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3214847HATs acetylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-3899300SUMOylation of transcription cofactors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-8957322Metabolism of steroids
reactomeR-HSA-9006931Signaling by Nuclear Receptors
reactomeR-HSA-9018519Estrogen-dependent gene expression

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD263AACOCF33
iGMDRD246NPC263
iGMDRD322FK 8665
iGMDRD353PD03259011
iGMDRD887Compound 23 citrate2
iGMDRD882CIL412
iGMDRD367Ro 28-16753
iGMDRD286Nsc 6328393
iGMDRD562Navitoclax2
iGMDRD329Merck603
iGMDRD105Triptolide3
iGMDRD6AM-5803
iGMDRD187BRD98763
iGMDRD870BRD636103
iGMDRD52Rotenone3
iGMDRD441TW 371
iGMDRD226ML0063
iGMDRD885Compound 1102
iGMDRD121GMX17786
iGMDRD255SB2250023
iGMDRD466Chaetocin3
iGMDRD280CYTOCHALASIN B6
iGMDRD211(1S,3R)-RSL32
iGMDRD901ELCPK3
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD144NSC953973
iGMDRD427ABT7373
iGMDRD150RITA3
iGMDRD701NVP-AUY9223
iGMDRD126Tipifarnib4
iGMDRD512nutlin 31

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NCOA1

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