RAPGEF2
Summary: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rap guanine nucleotide exchange factor 2 | MIM:609530 | Ensembl:ENSG00000109756 | HGNC:HGNC:16854 | PA130413152 | 4q32.1 |
GO terms in RAPGEF2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005770 | late endosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0005911 | cell-cell junction |
| CC | IDA | GO:0005923 | bicellular tight junction |
| CC | IDA | GO:0016020 | membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0030139 | endocytic vesicle |
| CC | ISS | GO:0032991 | protein-containing complex |
| CC | ISS | GO:0043005 | neuron projection |
| CC | ISS | GO:0043025 | neuronal cell body |
| CC | ISS | GO:0045202 | synapse |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | NAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0001568 | blood vessel development |
| BP | ISS | GO:0001764 | neuron migration |
| BP | IDA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007218 | neuropeptide signaling pathway |
| BP | TAS | GO:0007264 | small GTPase mediated signal transduction |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | ISS | GO:0010976 | positive regulation of neuron projection development |
| BP | IDA | GO:0019933 | cAMP-mediated signaling |
| BP | NAS | GO:0019933 | cAMP-mediated signaling |
| BP | ISS | GO:0021591 | ventricular system development |
| BP | ISS | GO:0021884 | forebrain neuron development |
| BP | IGI | GO:0030033 | microvillus assembly |
| BP | IDA | GO:0031175 | neuron projection development |
| BP | ISS | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway |
| BP | ISS | GO:0032092 | positive regulation of protein binding |
| BP | IMP | GO:0032486 | Rap protein signal transduction |
| BP | TAS | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0038180 | nerve growth factor signaling pathway |
| BP | IDA | GO:0043547 | positive regulation of GTPase activity |
| BP | IMP | GO:0043547 | positive regulation of GTPase activity |
| BP | IDA | GO:0043950 | positive regulation of cAMP-mediated signaling |
| BP | IDA | GO:0045860 | positive regulation of protein kinase activity |
| BP | ISS | GO:0048022 | negative regulation of melanin biosynthetic process |
| BP | ISS | GO:0048167 | regulation of synaptic plasticity |
| BP | IDA | GO:0050774 | negative regulation of dendrite morphogenesis |
| BP | IMP | GO:0061028 | establishment of endothelial barrier |
| BP | IDA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0071320 | cellular response to cAMP |
| BP | IDA | GO:0071321 | cellular response to cGMP |
| BP | IDA | GO:0071880 | adenylate cyclase-activating adrenergic receptor signaling pathway |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| BP | IMP | GO:0090557 | establishment of endothelial intestinal barrier |
| BP | IMP | GO:1901888 | regulation of cell junction assembly |
| BP | ISS | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | IDA | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity |
| BP | IDA | GO:2000670 | positive regulation of dendritic cell apoptotic process |
| BP | ISS | GO:2001214 | positive regulation of vasculogenesis |
| BP | ISS | GO:2001224 | positive regulation of neuron migration |
| MF | IDA | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | NAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0017034 | Rap guanyl-nucleotide exchange factor activity |
| MF | IMP | GO:0017034 | Rap guanyl-nucleotide exchange factor activity |
| MF | NAS | GO:0019992 | diacylglycerol binding |
| MF | IDA | GO:0030165 | PDZ domain binding |
| MF | IDA | GO:0030552 | cAMP binding |
| MF | IDA | GO:0030552 | cAMP binding |
| MF | IDA | GO:0030553 | cGMP binding |
| MF | IDA | GO:0031697 | beta-1 adrenergic receptor binding |
| MF | IDA | GO:0050699 | WW domain binding |
| MF | IDA | GO:0070300 | phosphatidic acid binding |
Gene expression in normal tissue: RAPGEF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAPGEF2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| wikipathways | WP382 | MAPK Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD701 | NVP-AUY922 | 4 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD192 | CIL56 | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD300 | Tozasertib | 10 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD151 | CHM-1 | 5 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD207 | Capsaicin | 2 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD268 | Cerulenin | 5 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD100 | Zebularine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAPGEF2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.