RAPGEF2

Summary: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameRap guanine nucleotide exchange factor 2
OMIM IDMIM:609530
Ensembl IDEnsembl:ENSG00000109756
HGNC IDHGNC:HGNC:16854
PHARMGKB IDPA130413152
Map Location4q32.1

GO terms in RAPGEF2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005737 cytoplasm
CC IDA GO:0005770 late endosome
CC IDA GO:0005829 cytosol
CC TAS GO:0005829 cytosol
CC ISS GO:0005886 plasma membrane
CC NAS GO:0005887 integral component of plasma membrane
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Gene expression in normal tissue: RAPGEF2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined32Protein stability and degradation2Apoptosis regulation2p53 pathway1Mitosis1WNT signaling1Proteasome1Metabolism1Metabolic pathways1Stilbenoid, diarylheptanoid and gingerol biosynthesis1

Pathways in RAPGEF2


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Database
Pathway ID
Pathway Des.
smpdb SMP00320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb SMP00321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
wikipathways WP382 MAPK Signaling Pathway
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
kegg hsa04015 Rap1 signaling pathway - Homo sapiens (human)
kegg hsa04530 Tight junction - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD701 NVP-AUY922 4
iGMDRD79 Gemcitabine 4
iGMDRD532 Olaparib 1
iGMDRD148 Pifithrin-mu 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAPGEF2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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