RAPGEF2


Summary: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Rap guanine nucleotide exchange factor 2MIM:609530Ensembl:ENSG00000109756HGNC:HGNC:16854PA1304131524q32.1

GO terms in RAPGEF2


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005737cytoplasm
CCIDAGO:0005770late endosome
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCISSGO:0005886plasma membrane
CCNASGO:0005887integral component of plasma membrane
CCISSGO:0005911cell-cell junction
CCIDAGO:0005923bicellular tight junction
CCIDAGO:0016020membrane
CCIDAGO:0016324apical plasma membrane
CCIDAGO:0030139endocytic vesicle
CCISSGO:0032991protein-containing complex
CCISSGO:0043005neuron projection
CCISSGO:0043025neuronal cell body
CCISSGO:0045202synapse
CCIDAGO:0048471perinuclear region of cytoplasm
BPNASGO:0000165MAPK cascade
BPTASGO:0000165MAPK cascade
BPISSGO:0001568blood vessel development
BPISSGO:0001764neuron migration
BPIDAGO:0007186G-protein coupled receptor signaling pathway
BPIDAGO:0007218neuropeptide signaling pathway
BPTASGO:0007264small GTPase mediated signal transduction
BPIDAGO:0008285negative regulation of cell proliferation
BPISSGO:0010976positive regulation of neuron projection development
BPIDAGO:0019933cAMP-mediated signaling
BPNASGO:0019933cAMP-mediated signaling
BPISSGO:0021591ventricular system development
BPISSGO:0021884forebrain neuron development
BPIGIGO:0030033microvillus assembly
BPIDAGO:0031175neuron projection development
BPISSGO:0031547brain-derived neurotrophic factor receptor signaling pathway
BPISSGO:0032092positive regulation of protein binding
BPIMPGO:0032486Rap protein signal transduction
BPTASGO:0035556intracellular signal transduction
BPISSGO:0038180nerve growth factor signaling pathway
BPIDAGO:0043547positive regulation of GTPase activity
BPIMPGO:0043547positive regulation of GTPase activity
BPIDAGO:0043950positive regulation of cAMP-mediated signaling
BPIDAGO:0045860positive regulation of protein kinase activity
BPISSGO:0048022negative regulation of melanin biosynthetic process
BPISSGO:0048167regulation of synaptic plasticity
BPIDAGO:0050774negative regulation of dendrite morphogenesis
BPIMPGO:0061028establishment of endothelial barrier
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0071320cellular response to cAMP
BPIDAGO:0071321cellular response to cGMP
BPIDAGO:0071880adenylate cyclase-activating adrenergic receptor signaling pathway
BPIMPGO:0072659protein localization to plasma membrane
BPIMPGO:0090557establishment of endothelial intestinal barrier
BPIMPGO:1901888regulation of cell junction assembly
BPISSGO:1990090cellular response to nerve growth factor stimulus
BPIDAGO:2000481positive regulation of cAMP-dependent protein kinase activity
BPIDAGO:2000670positive regulation of dendritic cell apoptotic process
BPISSGO:2001214positive regulation of vasculogenesis
BPISSGO:2001224positive regulation of neuron migration
MFIDAGO:0005088Ras guanyl-nucleotide exchange factor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIDAGO:0005096GTPase activator activity
MFNASGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIDAGO:0017034Rap guanyl-nucleotide exchange factor activity
MFIMPGO:0017034Rap guanyl-nucleotide exchange factor activity
MFNASGO:0019992diacylglycerol binding
MFIDAGO:0030165PDZ domain binding
MFIDAGO:0030552cAMP binding
MFIDAGO:0030552cAMP binding
MFIDAGO:0030553cGMP binding
MFIDAGO:0031697beta-1 adrenergic receptor binding
MFIDAGO:0050699WW domain binding
MFIDAGO:0070300phosphatidic acid binding

Gene expression in normal tissue: RAPGEF2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAPGEF2


DatabasePathway IDPathway Des.
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
wikipathwaysWP382MAPK Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD701NVP-AUY9224
iGMDRD79Gemcitabine4
iGMDRD532Olaparib1
iGMDRD148Pifithrin-mu3
iGMDRD512nutlin 31
iGMDRD307Manumycin A1
iGMDRD84Lovastatin acid2
iGMDRD177Teniposide3
iGMDRD211(1S,3R)-RSL33
iGMDRD901ELCPK1
iGMDRD237ABT-7512
iGMDRD314Tanespimycin1
iGMDRD77Itraconazole5
iGMDRD481Dactolisib1
iGMDRD192CIL562
iGMDRD289Parthenolide2
iGMDRD121GMX17785
iGMDRD202Curcumin1
iGMDRD158NSC1415405
iGMDRD322FK 8665
iGMDRD886Compound 1541A2
iGMDRD300Tozasertib10
iGMDRD329Merck602
iGMDRD872BRD71372
iGMDRD871BRD63682
iGMDRD414MST-3122
iGMDRD286Nsc 6328393
iGMDRD420Leucascandrolide A3
iGMDRD387CHIR-990212
iGMDRD151CHM-15
iGMDRD433Lexibulin1
iGMDRD634SCHEMBL26080411
iGMDRD152179324-69-72
iGMDRD193Fqi11
iGMDRD639YK 4-2792
iGMDRD446LY 21832403
iGMDRD187BRD98763
iGMDRD870BRD636103
iGMDRD318PAC-11
iGMDRD782DC-45-A23
iGMDRD207Capsaicin2
iGMDRD474Avrainvillamide3
iGMDRD451Serdemetan2
iGMDRD268Cerulenin5
iGMDRD64Parbendazole2
iGMDRD562Navitoclax2
iGMDRD577BIX012943
iGMDRD887Compound 23 citrate2
iGMDRD100Zebularine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAPGEF2

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