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iGMDRD639

Canonical SMILES: COC1=CC=C(C=C1)C(=O)CC2(C3=C(C=CC(=C3NC2=O)Cl)Cl)O

InChI: InChI=1S/C17H13Cl2NO4/c1-24-10-4-2-9(3-5-10)13(21)8-17(23)14-11(18)6-7-12(19)15(14)20-16(17)22/h2-7,23H,8H2,1H3,(H,20,22)

InChI Key: HLXSCTYHLQHQDJ-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
YK 4-279	CHEMBL2011500	44632000	Alone	Small Molecule

Drug Targets:

RNA helicase A DHX9 ERG ETV1

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
27125	AFF4	2
7514	XPO1	1
5027	P2RX7	2
132	ADK	3
5933	RBL1	3
79947	DHDDS	1
4627	MYH9	3
5546	PRCC	2
4168	MCF2	2
23513	SCRIB	2
2956	MSH6	1
1969	EPHA2	3
55215	FANCI	3
8289	ARID1A	2
4928	NUP98	2
2475	MTOR	3
83942	TSSK1B	1
3551	IKBKB	3
81035	COLEC12	3
7764	ZNF217	2
5241	PGR	3
56776	FMN2	2
1404	HAPLN1	3
9757	KMT2B	1
7048	TGFBR2	2
1387	CREBBP	3
1859	DYRK1A	3
5788	PTPRC	3
10013	HDAC6	3
2984	GUCY2C	2
79858	NEK11	1
5596	MAPK4	1
57472	CNOT6	3
8295	TRRAP	3
10438	C1D	1
5159	PDGFRB	1
55300	PI4K2B	3
2120	ETV6	2
7158	TP53BP1	1
9578	CDC42BPB	1
55728	N4BP2	3
25925	ZNF521	3
54477	PLEKHA5	3
440279	UNC13C	2
2115	ETV1	2
342977	NANOS3	3
2268	FGR	3
9693	RAPGEF2	2
32	ACACB	1
10342	TFG	3
6041	RNASEL	1
6091	ROBO1	2
116986	AGAP2	3
51343	FZR1	2
23255	MTCL1	2
730249	ACOD1	3
80129	CCDC170	3
4216	MAP3K4	3
2736	GLI2	2
284217	LAMA1	2
83931	STK40	3
375449	MAST4	2
287015	TRIM42	2
54899	PXK	2
23191	CYFIP1	3
440730	TRIM67	2
783	CACNB2	3
9759	HDAC4	2
1909	EDNRA	3
8515	ITGA10	2
3667	IRS1	2
80243	PREX2	2
4087	SMAD2	3
5450	POU2AF1	3
839	CASP6	3
10290	SPEG	2
1029	CDKN2A	1
7184	HSP90B1	3
657	BMPR1A	3
3236	HOXD10	3
5834	PYGB	1
648	BMI1	3
57194	ATP10A	3
8218	CLTCL1	3
3791	KDR	1
836	CASP3	3
2263	FGFR2	1
4086	SMAD1	1
1019	CDK4	3
11213	IRAK3	3
105	ADARB2	3
1555	CYP2B6	2
55034	MOCOS	3
55437	STRADB	3
984	CDK11B	3
7175	TPR	1
5871	MAP4K2	3
9401	RECQL4	3
80205	CHD9	3
84181	CHD6	3
4437	MSH3	1
23269	MGA	1
7994	KAT6A	3
4089	SMAD4	4
672	BRCA1	3
11168	PSIP1	3
23678	SGK3	1
5297	PI4KA	1
6134	RPL10	3
54756	IL17RD	3
50615	IL21R	3
5290	PIK3CA	1
3720	JARID2	3
26524	LATS2	3
10565	ARFGEF1	2
675	BRCA2	4
3458	IFNG	3
26166	RGS22	3
744	MPPED2	3
1956	EGFR	3
841	CASP8	3
2735	GLI1	2
4609	MYC	4
11064	CNTRL	2
64750	SMURF2	2
4684	NCAM1	2
5592	PRKG1	3
7917	BAG6	2
375056	MIA3	1
91754	NEK9	3
10186	LHFPL6	3
7153	TOP2A	3
1981	EIF4G1	3
1213	CLTC	4
22976	PAXIP1	3
3315	HSPB1	3
23532	PRAME	1
4863	NPAT	3
780	DDR1	3
8924	HERC2	1
6095	RORA	3
146057	TTBK2	3
8626	TP63	2
7849	PAX8	3
4853	NOTCH2	3
3229	HOXC13	3
10010	TANK	2
10752	CHL1	3
1869	E2F1	3
22883	CLSTN1	3
667	DST	2
83666	PARP9	2
23542	MAPK8IP2	1
6770	STAR	3
7273	TTN	2
171023	ASXL1	1
6789	STK4	1
7059	THBS3	3
23389	MED13L	3
54861	SNRK	3
2046	EPHA8	2
10249	GLYAT	3
1027	CDKN1B	1
8805	TRIM24	2
22843	PPM1E	1
286151	FBXO43	2
344905	ATP13A5	2
4297	KMT2A	2
558	AXL	3
9748	SLK	2
4619	MYH1	3
2067	ERCC1	1
9223	MAGI1	1
9659	PDE4DIP	1
54101	RIPK4	3
283455	KSR2	2
6093	ROCK1	3
2130	EWSR1	2
131890	GRK7	3
55007	FAM118A	3
57448	BIRC6	3
3717	JAK2	3
5506	PPP1R3A	1
8899	PRPF4B	3
8550	MAPKAPK5	3
23301	EHBP1	2
100862685	ERVK-19	1
80216	ALPK1	1
3656	IRAK2	3
182	JAG1	3
8661	EIF3A	3
7403	KDM6A	1
4302	MLLT6	3
51364	ZMYND10	3
197259	MLKL	2
3488	IGFBP5	1
2011	MARK2	3
2073	ERCC5	2
55422	ZNF331	3
1013	CDH15	3
4763	NF1	2
57697	FANCM	1
1612	DAPK1	2
57096	RPGRIP1	3
4629	MYH11	3
3679	ITGA7	3
27255	CNTN6	3
27151	CPAMD8	3
2892	GRIA3	3
5624	PROC	1
1488	CTBP2	3

Gene in drug-gene network: Network Plot

Models in YK 4-279

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DATATYPES

CLASSFICATION

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