ROCK1
Summary: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rho associated coiled-coil containing protein kinase 1 | MIM:601702 | Ensembl:ENSG00000067900 | HGNC:HGNC:10251 | PA34623 | 18q11.1 |
GO terms in ROCK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0017049 | GTP-Rho binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | ISS | GO:0001726 | ruffle |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005814 | centriole |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005856 | cytoskeleton |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0010494 | cytoplasmic stress granule |
| CC | ISS | GO:0030027 | lamellipodium |
| CC | IEA | GO:0032059 | bleb |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | IDA | GO:0106003 | amyloid-beta complex |
| BP | IEA | GO:0003383 | apical constriction |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006939 | smooth muscle contraction |
| BP | IDA | GO:0007159 | leukocyte cell-cell adhesion |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IMP | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IGI | GO:0007266 | Rho protein signal transduction |
| BP | TAS | GO:0010506 | regulation of autophagy |
| BP | IGI | GO:0010508 | positive regulation of autophagy |
| BP | IMP | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | ISS | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0016525 | negative regulation of angiogenesis |
| BP | IDA | GO:0022614 | membrane to membrane docking |
| BP | TAS | GO:0030036 | actin cytoskeleton organization |
| BP | TAS | GO:0030155 | regulation of cell adhesion |
| BP | IGI | GO:0030866 | cortical actin cytoskeleton organization |
| BP | IMP | GO:0030866 | cortical actin cytoskeleton organization |
| BP | IGI | GO:0031175 | neuron projection development |
| BP | IEA | GO:0032060 | bleb assembly |
| BP | IDA | GO:0032091 | negative regulation of protein binding |
| BP | IDA | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | TAS | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IGI | GO:0035509 | negative regulation of myosin-light-chain-phosphatase activity |
| BP | IMP | GO:0035509 | negative regulation of myosin-light-chain-phosphatase activity |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IMP | GO:0043410 | positive regulation of MAPK cascade |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IMP | GO:0045616 | regulation of keratinocyte differentiation |
| BP | IGI | GO:0045664 | regulation of neuron differentiation |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IDA | GO:0050900 | leukocyte migration |
| BP | IDA | GO:0050901 | leukocyte tethering or rolling |
| BP | TAS | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis |
| BP | ISS | GO:0051451 | myoblast migration |
| BP | TAS | GO:0051492 | regulation of stress fiber assembly |
| BP | TAS | GO:0051893 | regulation of focal adhesion assembly |
| BP | ISS | GO:0051894 | positive regulation of focal adhesion assembly |
| BP | ISS | GO:0070168 | negative regulation of biomineral tissue development |
| BP | ISS | GO:0071559 | response to transforming growth factor beta |
| BP | IGI | GO:0072659 | protein localization to plasma membrane |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| BP | IMP | GO:0110061 | regulation of angiotensin-activated signaling pathway |
| BP | IGI | GO:0140058 | neuron projection arborization |
| BP | IGI | GO:1900223 | positive regulation of amyloid-beta clearance |
| BP | IGI | GO:1900242 | regulation of synaptic vesicle endocytosis |
| BP | TAS | GO:1902003 | regulation of amyloid-beta formation |
| BP | IMP | GO:1902430 | negative regulation of amyloid-beta formation |
| BP | IMP | GO:1902992 | negative regulation of amyloid precursor protein catabolic process |
| BP | IGI | GO:1903140 | regulation of establishment of endothelial barrier |
| BP | IMP | GO:1903140 | regulation of establishment of endothelial barrier |
| BP | IGI | GO:1903347 | negative regulation of bicellular tight junction assembly |
| BP | IMP | GO:1905205 | positive regulation of connective tissue replacement |
| BP | ISS | GO:1990776 | response to angiotensin |
| BP | TAS | GO:2000114 | regulation of establishment of cell polarity |
| BP | TAS | GO:2000145 | regulation of cell motility |
Gene expression in normal tissue: ROCK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ROCK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP524 | G13 Signaling Pathway |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| pid | amb2_neutrophils_pathway | amb2 Integrin signaling |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| pid | epha_fwdpathway | EPHA forward signaling |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | prlsignalingeventspathway | Signaling events mediated by PRL |
| pid | rhoa_pathway | RhoA signaling pathway |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| pid | thrombin_par4_pathway | PAR4-mediated thrombin signaling events |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | malpathway | role of mal in rho-mediated activation of srf |
| biocarta | myosinpathway | pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase |
| biocarta | par1pathway | thrombin signaling and protease-activated receptors |
| biocarta | rhopathway | rho cell motility signaling pathway |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 8 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD163 | all trans Retinoic Acid | 3 |
| iGMDRD793 | BEC (hydrochloride) | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD126 | Tipifarnib | 8 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD598 | QS-11 | 3 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD398 | Sepantronium | 5 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 6 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ROCK1
CLASSFICATION
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