ROCK1


Summary: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015].

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OMIM ID
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GO terms in ROCK1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004672 protein kinase activity
MF IDA GO:0004674 protein serine/threonine kinase activity
MF NAS GO:0004674 protein serine/threonine kinase activity
MF TAS GO:0004674 protein serine/threonine kinase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
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Gene expression in normal tissue: ROCK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined38Apoptosis regulation3PI3K/MTOR signaling1Mitosis1Drug metabolism - cytochrome P4501Genome integrity1Other, kinases1Proteasome1Ferroptosis1Biosynthesis of secondary metabolites1

Pathways in ROCK1


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Database
Pathway ID
Pathway Des.
wikipathways WP138 Androgen receptor signaling pathway
wikipathways WP1544 MicroRNAs in cardiomyocyte hypertrophy
wikipathways WP185 Integrin-mediated Cell Adhesion
wikipathways WP2034 Leptin signaling pathway
wikipathways WP2038 Regulation of Microtubule Cytoskeleton
wikipathways WP2272 Pathogenic Escherichia coli infection
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD280 CYTOCHALASIN B 8
iGMDRD375 GW-405833 3
iGMDRD639 YK 4-279 3
iGMDRD316 N9-Isopropyl-olomoucine 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ROCK1

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Level
Reference ID
Tissue
Cancer
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Clinical Response
Source
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