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iGMDRD6

Canonical SMILES: CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C

InChI: InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)

InChI Key: SZWKGOZKRMMLAJ-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
AM-580	CHEMBL69367	2126	Alone	Small Molecule

Drug Targets:

RARA

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
7514	XPO1	1
5296	PIK3R2	3
5027	P2RX7	8
79848	CSPP1	4
7535	ZAP70	3
7837	PXDN	2
79054	TRPM8	2
10221	TRIB1	3
23085	ERC1	2
5261	PHKG2	2
21	ABCA3	4
6581	SLC22A3	3
6774	STAT3	3
7750	ZMYM2	2
4627	MYH9	2
5546	PRCC	3
8929	PHOX2B	6
817	CAMK2D	3
3845	KRAS	2
4750	NEK1	3
23552	CDK20	3
2100	ESR2	3
701	BUB1B	2
3939	LDHA	2
25778	DSTYK	6
4928	NUP98	3
7850	IL1R2	2
2176	FANCC	4
56776	FMN2	4
5079	PAX5	5
23235	SIK2	3
1786	DNMT1	3
10863	ADAM28	3
9891	NUAK1	3
4170	MCL1	1
3320	HSP90AA1	5
10142	AKAP9	2
27	ABL2	6
57172	CAMK1G	3
6318	SERPINB4	3
7048	TGFBR2	3
54822	TRPM7	3
943	TNFRSF8	2
1859	DYRK1A	3
5788	PTPRC	2
31	ACACA	1
9699	RIMS2	2
85021	REPS1	2
8295	TRRAP	2
5159	PDGFRB	1
55351	STK32B	1
9578	CDC42BPB	3
10746	MAP3K2	2
4595	MUTYH	2
23522	KAT6B	1
55728	N4BP2	2
57670	KIAA1549	2
4610	MYCL	2
816	CAMK2B	3
5900	RALGDS	3
342977	NANOS3	5
131096	KCNH8	3
8600	TNFSF11	3
8767	RIPK2	3
122011	CSNK1A1L	2
8549	LGR5	3
32	ACACB	3
2688	GH1	3
22806	IKZF3	3
2242	FES	3
9175	MAP3K13	2
6733	SRPK2	6
6091	ROBO1	4
2042	EPHA3	2
5330	PLCB2	3
23255	MTCL1	2
10188	TNK2	1
9636	ISG15	3
4216	MAP3K4	3
51804	SIX4	3
3688	ITGB1	2
9098	USP6	4
6928	HNF1B	5
4194	MDM4	2
1277	COL1A1	5
83983	TSSK6	2
3916	LAMP1	3
79971	WLS	2
54899	PXK	5
23191	CYFIP1	4
1456	CSNK1G3	3
6416	MAP2K4	1
9759	HDAC4	1
65987	KCTD14	2
1973	EIF4A1	6
1909	EDNRA	3
50488	MINK1	2
2068	ERCC2	3
8859	STK19	3
5568	PRKACG	2
8091	HMGA2	3
6098	ROS1	3
157285	PRAG1	5
638	BIK	3
130497	OSR1	3
3667	IRS1	3
472	ATM	3
4605	MYBL2	3
139285	AMER1	3
8148	TAF15	5
575	ADGRB1	3
53942	CNTN5	3
3397	ID1	1
5924	RASGRF2	1
9564	BCAR1	3
8038	ADAM12	2
5289	PIK3C3	4
5450	POU2AF1	7
91461	PKDCC	6
2272	FHIT	2
10290	SPEG	1
1029	CDKN2A	1
959	CD40LG	3
284656	EPHA10	1
657	BMPR1A	6
648	BMI1	6
4173	MCM4	2
8218	CLTCL1	6
3000	GUCY2D	3
225689	MAPK15	2
9639	ARHGEF10	3
1019	CDK4	1
65243	ZFP69B	1
1045	CDX2	1
4869	NPM1	2
8874	ARHGEF7	9
55034	MOCOS	3
23043	TNIK	2
369	ARAF	2
3187	HNRNPH1	2
652	BMP4	1
676	BRDT	3
5871	MAP4K2	9
80205	CHD9	2
4026	LPP	3
10499	NCOA2	1
4437	MSH3	7
2175	FANCA	2
4089	SMAD4	2
170692	ADAMTS18	2
54658	UGT1A1	2
1616	DAXX	3
11168	PSIP1	2
7204	TRIO	2
23373	CRTC1	3
10926	DBF4	2
57144	PAK5	4
5578	PRKCA	2
3702	ITK	1
50615	IL21R	2
5290	PIK3CA	3
92335	STRADA	3
26524	LATS2	5
5366	PMAIP1	3
6391	SDHC	2
5045	FURIN	3
10565	ARFGEF1	3
5530	PPP3CA	3
3458	IFNG	3
1956	EGFR	5
4318	MMP9	3
2735	GLI1	8
3065	HDAC1	3
90956	ADCK2	3
8021	NUP214	2
1326	MAP3K8	3
8795	TNFRSF10B	2
4684	NCAM1	2
894	CCND2	1
5156	PDGFRA	4
91754	NEK9	3
9159	PCSK7	2
27330	RPS6KA6	3
56924	PAK6	3
10186	LHFPL6	5
673	BRAF	4
84630	TTBK1	4
1981	EIF4G1	2
1769	DNAH8	2
988	CDC5L	3
3315	HSPB1	3
4863	NPAT	3
57507	ZNF608	3
8626	TP63	4
9113	LATS1	4
5294	PIK3CG	2
7849	PAX8	3
5378	PMS1	3
11262	SP140	2
157	GRK3	3
9509	ADAMTS2	3
23742	NPAP1	2
10010	TANK	2
55521	TRIM36	3
23476	BRD4	3
7030	TFE3	3
667	DST	2
1974	EIF4A2	5
284086	NEK8	3
83666	PARP9	1
6770	STAR	6
79834	PEAK1	2
5582	PRKCG	2
995	CDC25C	3
7465	WEE1	3
85415	RHPN2	3
55359	STYK1	3
2277	VEGFD	2
8648	NCOA1	3
2046	EPHA8	2
10249	GLYAT	3
8805	TRIM24	2
2072	ERCC4	1
4297	KMT2A	2
9748	SLK	2
83417	FCRL4	3
3297	HSF1	2
5923	RASGRF1	5
2317	FLNB	2
9021	SOCS3	2
8031	NCOA4	2
10111	RAD50	3
1789	DNMT3B	3
53353	LRP1B	1
7094	TLN1	2
2049	EPHB3	6
6093	ROCK1	3
4628	MYH10	3
5587	PRKD1	2
55007	FAM118A	6
1719	DHFR	5
5589	PRKCSH	5
5170	PDPK1	5
3717	JAK2	3
7099	TLR4	2
3709	ITPR2	2
57118	CAMK1D	3
8550	MAPKAPK5	3
3984	LIMK1	3
80216	ALPK1	4
3977	LIFR	2
4330	MN1	3
23250	ATP11A	6
5925	RB1	2
2065	ERBB3	3
25	ABL1	3
7403	KDM6A	1
54790	TET2	1
2308	FOXO1	3
255239	ANKK1	3
30849	PIK3R4	5
2011	MARK2	2
4915	NTRK2	3
142	PARP1	4
4591	TRIM37	2
5287	PIK3C2B	2
6868	ADAM17	3
23112	TNRC6B	2
2178	FANCE	2
5590	PRKCZ	3

Gene in drug-gene network: Network Plot

Models in AM-580

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.