PRAG1
Summary: This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| PEAK1 related, kinase-activating pseudokinase 1 | MIM:617344 | Ensembl:ENSG00000275342 | HGNC:HGNC:25438 | 8p23.1 |
GO terms in PRAG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0008360 | regulation of cell shape |
| BP | ISS | GO:0008593 | regulation of Notch signaling pathway |
| BP | ISS | GO:0010977 | negative regulation of neuron projection development |
| BP | IMP | GO:0016477 | cell migration |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0035025 | positive regulation of Rho protein signal transduction |
| BP | ISS | GO:2000145 | regulation of cell motility |
| CC | ISS | GO:0005634 | nucleus |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005925 | focal adhesion |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0005524 | ATP binding |
| MF | IDA | GO:0042802 | identical protein binding |
Gene expression in normal tissue: PRAG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRAG1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD698 | Neratinib | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD48 | Dexamethasone | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD67 | PENFLURIDOL | 6 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD662 | JQ-1 | 6 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD6 | AM-580 | 5 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD52 | Rotenone | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRAG1
CLASSFICATION
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