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iGMDRD505

Canonical SMILES: C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=O)N

InChI: InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/s1

InChI Key: MPUQHZXIXSTTDU-QXGSTGNESA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Pevonedistat	CHEMBL2364622 CHEMBL1231160	16720800	DB11759	Alone	Small Molecule

Drug Class:

Cycloparaffins Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Hydrocarbons Hydrocarbons, Alicyclic Hydrocarbons, Cyclic Macrocyclic Compounds Polycyclic Compounds

Drug Targets:

NEDD8-activating enzyme NAE1

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	3
1105	CHD1	2
4854	NOTCH3	2
7514	XPO1	1
8999	CDKL2	1
5296	PIK3R2	2
5027	P2RX7	3
10903	MTMR11	2
7837	PXDN	3
10641	NPRL2	1
7128	TNFAIP3	3
8444	DYRK3	3
6774	STAT3	4
8476	CDC42BPA	6
11183	MAP4K5	4
840	CASP7	3
4627	MYH9	5
8929	PHOX2B	3
2956	MSH6	1
2200	FBN1	7
57554	LRRC7	2
9149	DYRK1B	1
7272	TTK	5
3845	KRAS	1
3757	KCNH2	2
4750	NEK1	2
5295	PIK3R1	5
55215	FANCI	3
8289	ARID1A	6
6351	CCL4	2
80070	ADAMTS20	11
51231	VRK3	3
25778	DSTYK	2
6597	SMARCA4	5
5916	RARG	3
3326	HSP90AB1	3
9869	SETDB1	3
7764	ZNF217	6
353345	GPR141	2
5133	PDCD1	1
3069	HDLBP	3
10320	IKZF1	1
7942	TFEB	1
6657	SOX2	5
64783	RBM15	1
4771	NF2	2
9891	NUAK1	3
23213	SULF1	3
3066	HDAC2	4
10142	AKAP9	6
7253	TSHR	4
10645	CAMKK2	6
8749	ADAM18	7
22821	RASA3	2
1545	CYP1B1	2
140469	MYO3B	2
604	BCL6	3
51199	NIN	6
80122	MAP3K19	2
202374	STK32A	1
1387	CREBBP	2
1893	ECM1	3
8844	KSR1	4
2313	FLI1	6
31	ACACA	4
10178	TENM1	8
79858	NEK11	2
9048	ARTN	2
5596	MAPK4	2
3055	HCK	6
8295	TRRAP	4
26576	SRPK3	3
10438	C1D	6
9024	BRSK2	3
7373	COL14A1	1
5166	PDK4	3
7158	TP53BP1	1
55294	FBXW7	8
10295	BCKDK	3
2033	EP300	2
54567	DLL4	2
5664	PSEN2	6
9578	CDC42BPB	2
641	BLM	3
4361	MRE11	4
83439	TCF7L1	3
4595	MUTYH	3
55728	N4BP2	1
25925	ZNF521	2
54477	PLEKHA5	5
57670	KIAA1549	4
440279	UNC13C	5
2115	ETV1	1
4301	AFDN	5
5743	PTGS2	3
84033	OBSCN	10
342667	STAC2	3
342977	NANOS3	3
256646	NUTM1	3
1540	CYLD	1
8600	TNFSF11	3
122011	CSNK1A1L	6
57787	MARK4	4
26353	HSPB8	2
64083	GOLPH3	2
22806	IKZF3	3
10342	TFG	3
7416	VDAC1	1
6041	RNASEL	1
6733	SRPK2	2
6091	ROBO1	2
116986	AGAP2	1
5330	PLCB2	1
23255	MTCL1	3
5984	RFC4	3
10188	TNK2	3
10217	CTDSPL	4
4216	MAP3K4	6
2736	GLI2	5
6198	RPS6KB1	6
83990	BRIP1	6
5601	MAPK9	3
284217	LAMA1	4
269	AMHR2	6
4982	TNFRSF11B	2
2045	EPHA7	3
23405	DICER1	5
171019	ADAMTS19	3
375449	MAST4	2
983	CDK1	1
65266	WNK4	2
287015	TRIM42	3
83983	TSSK6	3
65217	PCDH15	6
834	CASP1	3
23387	SIK3	6
783	CACNB2	3
8714	ABCC3	4
6709	SPTAN1	3
219970	GLYATL2	3
1909	EDNRA	3
2068	ERCC2	5
9472	AKAP6	4
157285	PRAG1	1
2778	GNAS	6
3685	ITGAV	2
80243	PREX2	2
472	ATM	1
8945	BTRC	6
1009	CDH11	2
139285	AMER1	4
83903	HASPIN	6
8148	TAF15	4
2734	GLG1	2
11344	TWF2	3
8038	ADAM12	3
4058	LTK	2
1123	CHN1	2
7010	TEK	8
5450	POU2AF1	2
898	CCNE1	3
23152	CIC	2
2066	ERBB4	1
7681	MKRN3	4
5327	PLAT	2
2201	FBN2	2
7184	HSP90B1	2
5108	PCM1	3
27436	EML4	4
657	BMPR1A	3
861	RUNX1	2
5834	PYGB	1
58508	KMT2C	7
7157	TP53	1
2099	ESR1	2
6092	ROBO2	4
27086	FOXP1	6
79058	ASPSCR1	2
2322	FLT3	2
4857	NOVA1	2
8218	CLTCL1	3
397	ARHGDIB	3
4292	MLH1	3
54498	SMOX	7
84513	PLPP5	3
3000	GUCY2D	1
2263	FGFR2	2
4086	SMAD1	1
106480993	RN7SL263P	3
7249	TSC2	2
7409	VAV1	10
84075	FSCB	8
344387	CDKL4	3
5597	MAPK6	4
23043	TNIK	5
2309	FOXO3	1
4921	DDR2	1
57188	ADAMTSL3	1
55589	BMP2K	3
65125	WNK1	3
136332	LRGUK	5
652	BMP4	1
9401	RECQL4	6
84181	CHD6	8
57578	UNC79	3
57111	RAB25	1
4089	SMAD4	6
170692	ADAMTS18	6
54658	UGT1A1	1
6654	SOS1	7
2060	EPS15	3
4139	MARK1	3
7204	TRIO	5
256536	TCERG1L	1
139760	GPR119	2
9448	MAP4K4	3
546	ATRX	3
23678	SGK3	3
2047	EPHB1	2
501	ALDH7A1	6
5578	PRKCA	3
4214	MAP3K1	2
440275	EIF2AK4	4
8731	RNMT	5
9972	NUP153	3
3239	HOXD13	3
5290	PIK3CA	1
3720	JARID2	7
1514	CTSL	8
1000	CDH2	8
26524	LATS2	3
57154	SMURF1	3
675	BRCA2	6
26166	RGS22	2
7075	TIE1	2
1956	EGFR	13
8445	DYRK2	6
157680	VPS13B	1
841	CASP8	1
3065	HDAC1	6
64333	ARHGAP9	2
11064	CNTRL	6
3308	HSPA4	3
5789	PTPRD	2
26278	SACS	3
5462	POU5F1B	2
6776	STAT5A	11
3553	IL1B	4
8900	CCNA1	2
5187	PER1	1
91754	NEK9	3
93627	TBCK	9
56924	PAK6	2
673	BRAF	6
7153	TOP2A	4
57082	KNL1	5
1213	CLTC	6
1769	DNAH8	3
5781	PTPN11	7
3315	HSPB1	1
780	DDR1	6
83452	RAB33B	3
57538	ALPK3	3
8924	HERC2	3
6469	SHH	3
339345	NANOS2	1
120892	LRRK2	6
6095	RORA	9
29844	TFPT	2
8029	CUBN	2
8626	TP63	3
9113	LATS1	9
9064	MAP3K6	3
5294	PIK3CG	3
1024	CDK8	3
7849	PAX8	4
9321	TRIP11	7
9451	EIF2AK3	4
11262	SP140	2
23396	PIP5K1C	1
3654	IRAK1	6
23742	NPAP1	1
8312	AXIN1	3
10752	CHL1	2
5728	PTEN	2
57521	RPTOR	6
51592	TRIM33	2
1869	E2F1	3
22883	CLSTN1	11
667	DST	6
23281	MTUS2	2
115701	ALPK2	1
352909	DNAAF3	1
6770	STAR	5
2188	FANCF	6
6146	RPL22	8
2648	KAT2A	1
1950	EGF	6
8522	GAS7	6
171023	ASXL1	1
79834	PEAK1	3
6789	STK4	4
23332	CLASP1	1
85415	RHPN2	1
29941	PKN3	3
9372	ZFYVE9	4
2046	EPHA8	3
128869	PIGU	3
22843	PPM1E	3
4297	KMT2A	5
1493	CTLA4	8
10076	PTPRU	2
4619	MYH1	3
57680	CHD8	11
9223	MAGI1	1
778	CACNA1F	5
1281	COL3A1	5
9659	PDE4DIP	3
9201	DCLK1	1
63976	PRDM16	3
283455	KSR2	6
6093	ROCK1	3
131890	GRK7	5
5927	KDM5A	6
598	BCL2L1	2
5587	PRKD1	6
4215	MAP3K3	3
6196	RPS6KA2	2
57448	BIRC6	6
57007	ACKR3	3
8317	CDC7	5
3717	JAK2	3
2157	F8	4
5506	PPP1R3A	2
1627	DBN1	3
6778	STAT6	3
8428	STK24	8
51562	MBIP	2
3516	RBPJ	2
6777	STAT5B	4
3977	LIFR	2
7112	TMPO	6
170685	NUDT10	5
5894	RAF1	1
182	JAG1	3
7046	TGFBR1	4
2122	MECOM	6
51167	CYB5R4	2
5087	PBX1	3
2903	GRIN2A	5
4974	OMG	2
1515	CTSV	2
4893	NRAS	2
5584	PRKCI	3
63923	TNN	7
2065	ERBB3	6
2074	ERCC6	2
25	ABL1	3
862	RUNX1T1	3
3691	ITGB4	2
10420	TESK2	2
7403	KDM6A	1
55959	SULF2	1
3488	IGFBP5	1
3480	IGF1R	3
55869	HDAC8	9
11086	ADAM29	6
142	PARP1	4
2261	FGFR3	4
23072	HECW1	3
55422	ZNF331	4
55746	NUP133	1
4763	NF1	4
57697	FANCM	4
5260	PHKG1	7
1994	ELAVL1	1
4613	MYCN	1
63893	UBE2O	3
1840	DTX1	2
10891	PPARGC1A	5
94	ACVRL1	1
2044	EPHA5	2
5287	PIK3C2B	2
4629	MYH11	3
3679	ITGA7	3
81788	NUAK2	4
10048	RANBP9	3
6868	ADAM17	6
1803	DPP4	1
5885	RAD21	2
1499	CTNNB1	4
2444	FRK	1
56155	TEX14	3
4916	NTRK3	2

Gene in drug-gene network: Network Plot

Models in Pevonedistat

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.