SOS1

Summary: This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSOS Ras/Rac guanine nucleotide exchange factor 1
OMIM IDMIM:182530
Ensembl IDEnsembl:ENSG00000115904
HGNC IDHGNC:HGNC:11187
PHARMGKB IDPA36024
Map Location2p22.1

GO terms in SOS1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0000165 MAPK cascade
BP IEA GO:0001782 B cell homeostasis
BP IEA GO:0001942 hair follicle development
BP IEA GO:0003209 cardiac atrium morphogenesis
BP IEA GO:0003344 pericardium morphogenesis
BP NAS GO:0007165 signal transduction
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Gene expression in normal tissue: SOS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined59Apoptosis regulation5ERK MAPK signaling3Breast cancer2Cell cycle2Other, kinases2Biosynthesis of secondary metabolites1Proteasome1IGFR signaling1Longevity regulating pathway1

Pathways in SOS1


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Database
Pathway ID
Pathway Des.
biocarta at1rpathway angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocarta bcrpathway bcr signaling pathway
biocarta biopeptidespathway bioactive peptide induced signaling pathway
biocarta cardiacegfpathway role of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocarta cdk5pathway phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway
biocarta crebpathway transcription factor creb and its extracellular signals
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD886 Compound 1541A 4
iGMDRD300 Tozasertib 4
iGMDRD505 Pevonedistat 7
iGMDRD545 SGX-523 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SOS1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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