iGMDRD545

Canonical SMILES: CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2

InChI: InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3

InChI Key: BCZUAADEACICHN-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameSGX-523
CHEMBLCHEMBL1236107
Pubchem CID24779700
DRUGBANK IDDB08584
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

MET (P08581)

Drug-model tissue-cancer distribution: Bubble Plot

SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3BRAItissue: BRAI cancer: BRAIN model num: 0BRAINtissue: BRAIN cancer: Glioblastoma Multiforme (GBM) model num: 1

Drug-gene pathway enrichments

5reactome: Signal Transduction4reactome: Signaling by Receptor Tyrosine Kinases4reactome: Signaling by ERBB23reactome: SHC1 events in ERBB2 signaling2reactome: Diseases of signal transduction2reactome: Signaling by NTRK1 (TRKA)2reactome: RAF/MAP kinase cascade2reactome: MAPK family signaling cascades2reactome: IRS-mediated signalling2reactome: MAPK1/MAPK3 signaling

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
57580 PREX1 1
6654 SOS1 1
2065 ERBB3 1
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

Models in SGX-523

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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