PREX1


Summary: The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1MIM:606905Ensembl:ENSG00000124126HGNC:HGNC:32594PA16472501820q13.13

Gene Categories:

KINASE

GO terms in PREX1


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006469negative regulation of protein kinase activity
BPTASGO:0006801superoxide metabolic process
BPIBAGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0030041actin filament polymerization
BPIEAGO:0030217T cell differentiation
BPIEAGO:0030335positive regulation of cell migration
BPIEAGO:0030593neutrophil chemotaxis
BPIEAGO:0030833regulation of actin filament polymerization
BPIBAGO:0032007negative regulation of TOR signaling
BPIEAGO:0035023regulation of Rho protein signal transduction
BPIEAGO:0035556intracellular signal transduction
BPTASGO:0042119neutrophil activation
BPTASGO:0043065positive regulation of apoptotic process
BPIEAGO:0043547positive regulation of GTPase activity
BPIEAGO:0050773regulation of dendrite development
BPTASGO:0051056regulation of small GTPase mediated signal transduction
BPIEAGO:1900026positive regulation of substrate adhesion-dependent cell spreading
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0030426growth cone
CCIEAGO:0043198dendritic shaft
CCIEAGO:0048471perinuclear region of cytoplasm
MFTASGO:0005085guanyl-nucleotide exchange factor activity
MFTASGO:0005089Rho guanyl-nucleotide exchange factor activity
MFTASGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFIDAGO:0005543phospholipid binding
MFTASGO:0019899enzyme binding
MFIBAGO:0030676Rac guanyl-nucleotide exchange factor activity

Gene expression in normal tissue: PREX1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PREX1


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-193648NRAGE signals death through JNK
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416482G alpha (12/13) signalling events
reactomeR-HSA-73887Death Receptor Signalling
pidrac1_reg_pathwayRegulation of RAC1 activity
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
wikipathwaysWP3929Chemokine signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD865BRD-M000538011
iGMDRD124Canertinib1
iGMDRD444Tivantinib1
iGMDRD545SGX-5231
iGMDRD451Serdemetan1
iGMDRD384EHT-18641
iGMDRD263AACOCF31
iGMDRD246NPC261
iGMDRD3PD-1730741
iGMDRD473GDC-08791
iGMDRD399Selumetinib1
iGMDRD560MK-22061
iGMDRD1008SR-II-138A1
iGMDRD410Ko-1431
iGMDRD404PD3180881
iGMDRD595PLX40321
iGMDRD394BX-7951
iGMDRD536PLX-47201
iGMDRD358Semagacestat1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PREX1

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