PREX1
Summary: The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 | MIM:606905 | Ensembl:ENSG00000124126 | HGNC:HGNC:32594 | PA164725018 | 20q13.13 |
Gene Categories:
KINASEGO terms in PREX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006469 | negative regulation of protein kinase activity |
| BP | TAS | GO:0006801 | superoxide metabolic process |
| BP | IBA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0030041 | actin filament polymerization |
| BP | IEA | GO:0030217 | T cell differentiation |
| BP | IEA | GO:0030335 | positive regulation of cell migration |
| BP | IEA | GO:0030593 | neutrophil chemotaxis |
| BP | IEA | GO:0030833 | regulation of actin filament polymerization |
| BP | IBA | GO:0032007 | negative regulation of TOR signaling |
| BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0042119 | neutrophil activation |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IEA | GO:0050773 | regulation of dendrite development |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IEA | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0030426 | growth cone |
| CC | IEA | GO:0043198 | dendritic shaft |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005543 | phospholipid binding |
| MF | TAS | GO:0019899 | enzyme binding |
| MF | IBA | GO:0030676 | Rac guanyl-nucleotide exchange factor activity |
Gene expression in normal tissue: PREX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PREX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| pid | rac1_reg_pathway | Regulation of RAC1 activity |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| wikipathways | WP3929 | Chemokine signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD865 | BRD-M00053801 | 1 |
| iGMDRD124 | Canertinib | 1 |
| iGMDRD444 | Tivantinib | 1 |
| iGMDRD545 | SGX-523 | 1 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD384 | EHT-1864 | 1 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD3 | PD-173074 | 1 |
| iGMDRD473 | GDC-0879 | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD410 | Ko-143 | 1 |
| iGMDRD404 | PD318088 | 1 |
| iGMDRD595 | PLX4032 | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD358 | Semagacestat | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PREX1
CLASSFICATION
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