PREX1

Summary: The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namephosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
OMIM IDMIM:606905
Ensembl IDEnsembl:ENSG00000124126
HGNC IDHGNC:HGNC:32594
PHARMGKB IDPA164725018
Map Location20q13.13

Gene Categories:

KINASE

GO terms in PREX1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0006469 negative regulation of protein kinase activity
BP TAS GO:0006801 superoxide metabolic process
BP IBA GO:0007186 G-protein coupled receptor signaling pathway
BP TAS GO:0007186 G-protein coupled receptor signaling pathway
BP TAS GO:0030041 actin filament polymerization
BP IEA GO:0030217 T cell differentiation
Showing 1 to 6 of 32 rows rows per page

Gene expression in normal tissue: PREX1

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 4SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 11OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 1LIVEtissue: LIVE cancer: LIVER model num: 0LIVERtissue: LIVER cancer: undefined model num: 2undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

undefined11ERK MAPK signaling3RTK signaling2PI3K/MTOR signaling1p53 pathway1Cytoskeleton1

Pathways in PREX1


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-193648 NRAGE signals death through JNK
reactome R-HSA-193704 p75 NTR receptor-mediated signalling
reactome R-HSA-194315 Signaling by Rho GTPases
reactome R-HSA-194840 Rho GTPase cycle
reactome R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE
Showing 1 to 6 of 14 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD865 BRD-M00053801 1
iGMDRD124 Canertinib 1
iGMDRD444 Tivantinib 1
iGMDRD545 SGX-523 1
Showing 1 to 4 of 19 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PREX1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.