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iGMDRD444

Canonical SMILES: C1CC2=CC=CC3=C2N(C1)C=C3C4C(C(=O)NC4=O)C5=CNC6=CC=CC=C65

InChI: InChI=1S/C23H19N3O2/c27-22-19(16-11-24-18-9-2-1-7-14(16)18)20(23(28)25-22)17-12-26-10-4-6-13-5-3-8-15(17)21(13)26/h1-3,5,7-9,11-12,19-20,24H,4,6,10H2,(H,25,27,28)/t19-,20-/m0/s1

InChI Key: UCEQXRCJXIVODC-PMACEKPBSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Tivantinib	CHEMBL2103882	11494400	DB12200	Alone	Small Molecule

Drug Class:

Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Heterocyclic Compounds, 2-Ring Proto-Oncogene Proteins c-met, antagonists & inhibitors Pyrrolidines

Drug Targets:

MET (P08581)FLT1 FLT3 KDR

Drug Pathways:

RTK signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
132	ADK	3
4926	NUMA1	2
23513	SCRIB	3
2956	MSH6	1
5295	PIK3R1	4
3551	IKBKB	3
57580	PREX1	1
10013	HDAC6	2
57472	CNOT6	3
5966	REL	3
5159	PDGFRB	2
2042	EPHA3	1
51804	SIX4	2
57476	GRAMD1B	1
65217	PCDH15	1
783	CACNB2	2
50488	MINK1	2
7010	TEK	1
839	CASP6	3
2201	FBN2	2
9794	MAML1	2
3932	LCK	3
57194	ATP10A	3
8218	CLTCL1	2
3791	KDR	1
836	CASP3	3
2263	FGFR2	1
4086	SMAD1	1
5585	PKN1	3
55437	STRADB	3
84181	CHD6	3
7994	KAT6A	3
4089	SMAD4	1
6134	RPL10	3
10565	ARFGEF1	2
64750	SMURF2	2
6885	MAP3K7	3
23604	DAPK2	3
10186	LHFPL6	1
1213	CLTC	2
4790	NFKB1	2
867	CBL	1
6095	RORA	2
7301	TYRO3	1
3229	HOXC13	3
10010	TANK	2
22883	CLSTN1	1
23389	MED13L	2
53904	MYO3A	1
10595	ERN2	2
5581	PRKCE	2
100124696	TEC	2
53353	LRP1B	3
3557	IL1RN	3
2130	EWSR1	2
6653	SORL1	1
2065	ERBB3	1
197259	MLKL	2
2073	ERCC5	2
4763	NF1	3
1612	DAPK1	2
138474	TAF1L	3
23683	PRKD3	3
1803	DPP4	2

Gene in drug-gene network: Network Plot

Models in Tivantinib

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.