PKN1

Summary: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameprotein kinase N1
OMIM IDMIM:601032
Ensembl IDEnsembl:ENSG00000123143
HGNC IDHGNC:HGNC:9405
PHARMGKB IDPA33769
Map Location19p13.12

GO terms in PKN1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0003682 chromatin binding
MF TAS GO:0004672 protein kinase activity
MF EXP GO:0004674 protein serine/threonine kinase activity
MF IBA GO:0004674 protein serine/threonine kinase activity
MF IDA GO:0004674 protein serine/threonine kinase activity
MF TAS GO:0004674 protein serine/threonine kinase activity
Showing 1 to 6 of 47 rows rows per page

Gene expression in normal tissue: PKN1

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 12LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 22undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 42undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 6OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 6BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 1SKINtissue: SKIN cancer: Melanoma (MEL) model num: 1

Gene-drug pathway distribution

Pathways in PKN1


Loading, please wait...
Database
Pathway ID
Pathway Des.
pid ar_tf_pathway Regulation of Androgen receptor activity
pid p38gammadeltapathway Signaling mediated by p38-gamma and p38-delta
pid rhoa_pathway RhoA signaling pathway
pid thrombin_par1_pathway PAR1-mediated thrombin signaling events
netpath Pathway_TNFalpha TNFalpha
kegg hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
Showing 1 to 6 of 17 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 3
iGMDRD188 Piperlongumine 3
iGMDRD366 PI-103 1
iGMDRD562 Navitoclax 6
Showing 1 to 4 of 31 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PKN1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.