PKN1
Summary: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase N1 | MIM:601032 | Ensembl:ENSG00000123143 | HGNC:HGNC:9405 | PA33769 | 19p13.12 |
GO terms in PKN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003682 | chromatin binding |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004697 | protein kinase C activity |
| MF | IPI | GO:0005080 | protein kinase C binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0017049 | GTP-Rho binding |
| MF | IDA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IMP | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IDA | GO:0035402 | histone kinase activity (H3-T11 specific) |
| MF | IDA | GO:0042393 | histone binding |
| MF | IDA | GO:0042826 | histone deacetylase binding |
| MF | IDA | GO:0048365 | Rac GTPase binding |
| MF | IDA | GO:0050681 | androgen receptor binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005768 | endosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0030496 | midbody |
| CC | IDA | GO:0032154 | cleavage furrow |
| CC | IEA | GO:0032991 | protein-containing complex |
| BP | IEA | GO:0001782 | B cell homeostasis |
| BP | IEA | GO:0001783 | B cell apoptotic process |
| BP | IEA | GO:0002634 | regulation of germinal center formation |
| BP | IEA | GO:0002637 | regulation of immunoglobulin production |
| BP | IEA | GO:0003014 | renal system process |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IEA | GO:0006972 | hyperosmotic response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007257 | activation of JUN kinase activity |
| BP | IMP | GO:0010631 | epithelial cell migration |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0030889 | negative regulation of B cell proliferation |
| BP | IDA | GO:0035407 | histone H3-T11 phosphorylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0048536 | spleen development |
| BP | IEA | GO:1903508 | positive regulation of nucleic acid-templated transcription |
| BP | IMP | GO:2000145 | regulation of cell motility |
Gene expression in normal tissue: PKN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PKN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | p38gammadeltapathway | Signaling mediated by p38-gamma and p38-delta |
| pid | rhoa_pathway | RhoA signaling pathway |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP524 | G13 Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
| reactome | R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
| biocarta | akapcentrosomepathway | protein kinase a at the centrosome |
| biocarta | myosinpathway | pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD524 | ISX-9 | 4 |
| iGMDRD137 | Indisulam | 7 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD772 | BRD4770 | 5 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD966 | PAK inhibitor | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD781 | Sirolimus | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PKN1
CLASSFICATION
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