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iGMDRD255

Canonical SMILES: C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br

InChI: InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)

InChI Key: MQBZVUNNWUIPMK-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
SB225002	CHEMBL239767	3854670	Alone	Small Molecule

Drug Targets:

CXCR2

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
64901	RANBP17	5
27125	AFF4	2
7514	XPO1	1
6664	SOX11	1
8019	BRD3	3
5027	P2RX7	1
997	CDC34	3
471	ATIC	2
7837	PXDN	3
1464	CSPG4	2
23085	ERC1	2
6491	STIL	6
10987	COPS5	4
6581	SLC22A3	3
6774	STAT3	2
7750	ZMYM2	4
29101	SSU72	3
4627	MYH9	2
5546	PRCC	5
10806	SDCCAG8	3
4168	MCF2	4
2956	MSH6	1
2200	FBN1	3
55872	PBK	3
57679	ALS2	1
57554	LRRC7	7
9149	DYRK1B	3
51347	TAOK3	6
4750	NEK1	4
55215	FANCI	3
8289	ARID1A	3
80070	ADAMTS20	3
701	BUB1B	3
51231	VRK3	6
11193	WBP4	2
84700	MYO18B	3
53616	ADAM22	2
3431	SP110	2
6938	TCF12	2
2475	MTOR	4
9869	SETDB1	6
4036	LRP2	5
11160	ERLIN2	3
10320	IKZF1	4
79820	CATSPERB	3
7444	VRK2	3
56776	FMN2	3
64783	RBM15	2
4771	NF2	2
23235	SIK2	1
6598	SMARCB1	3
4170	MCL1	1
1607	DGKB	5
5218	CDK14	3
7253	TSHR	3
7098	TLR3	3
27	ABL2	2
3841	KPNA5	7
2241	FER	4
22821	RASA3	3
84299	MIEN1	8
1545	CYP1B1	2
114908	TMEM123	1
2249	FGF4	3
79934	COQ8B	4
54822	TRPM7	3
114783	LMTK3	3
202374	STK32A	2
1387	CREBBP	2
10454	TAB1	3
2043	EPHA4	3
3727	JUND	3
5579	PRKCB	3
31	ACACA	2
1602	DACH1	2
79858	NEK11	3
5966	REL	2
3604	TNFRSF9	4
29998	BICRA	2
8295	TRRAP	4
10438	C1D	6
9024	BRSK2	3
5159	PDGFRB	1
55300	PI4K2B	3
10215	OLIG2	3
4851	NOTCH1	8
5314	PKHD1	1
139378	ADGRG4	6
7158	TP53BP1	1
10295	BCKDK	2
2033	EP300	8
6927	HNF1A	3
4001	LMNB1	3
9578	CDC42BPB	2
5914	RARA	5
83439	TCF7L1	3
55728	N4BP2	3
7852	CXCR4	3
54477	PLEKHA5	3
57670	KIAA1549	3
284521	OR2L13	2
4610	MYCL	2
2115	ETV1	1
4301	AFDN	4
5081	PAX7	3
55819	RNF130	3
84033	OBSCN	8
51776	MAP3K20	3
152137	CCDC50	3
815	CAMK2A	3
1880	GPR183	2
57787	MARK4	3
3927	LASP1	2
1586	CYP17A1	3
1591	CYP24A1	6
32	ACACB	2
329	BIRC2	1
4300	MLLT3	1
22806	IKZF3	4
2242	FES	1
6041	RNASEL	2
6733	SRPK2	3
6091	ROBO1	2
2260	FGFR1	3
4216	MAP3K4	5
2736	GLI2	3
29904	EEF2K	3
2908	NR3C1	2
83990	BRIP1	6
51804	SIX4	2
4739	NEDD9	6
4194	MDM4	2
1984	EIF5A	1
7088	TLE1	2
284217	LAMA1	6
7424	VEGFC	3
1992	SERPINB1	3
238	ALK	3
1277	COL1A1	4
7078	TIMP3	3
375449	MAST4	1
2064	ERBB2	4
94103	ORMDL3	11
6850	SYK	2
287015	TRIM42	3
57476	GRAMD1B	4
8395	PIP5K1B	2
6663	SOX10	3
26750	RPS6KC1	2
993	CDC25A	3
286826	LIN9	3
23387	SIK3	5
1456	CSNK1G3	3
783	CACNB2	5
4140	MARK3	3
5127	CDK16	2
92	ACVR2A	2
10400	PEMT	3
6709	SPTAN1	2
158056	MAMDC4	4
50488	MINK1	3
2068	ERCC2	2
8091	HMGA2	1
6464	SHC1	3
9472	AKAP6	4
8515	ITGA10	5
2778	GNAS	6
6917	TCEA1	2
80243	PREX2	3
8945	BTRC	5
5165	PDK3	3
1009	CDH11	4
139285	AMER1	2
3418	IDH2	3
2521	FUS	2
53942	CNTN5	3
84433	CARD11	3
9564	BCAR1	2
6792	CDKL5	3
7010	TEK	4
7533	YWHAH	5
23152	CIC	2
2272	FHIT	3
2066	ERBB4	1
1647	GADD45A	6
5863	RGL2	6
10290	SPEG	1
1029	CDKN2A	3
5129	CDK18	3
57523	NYNRIN	7
1910	EDNRB	3
2868	GRK4	4
28514	DLL1	3
5834	PYGB	1
3932	LCK	6
58508	KMT2C	3
7157	TP53	2
6092	ROBO2	2
4173	MCM4	2
3673	ITGA2	1
79058	ASPSCR1	4
6714	SRC	1
4296	MAP3K11	5
57194	ATP10A	2
25836	NIPBL	2
8218	CLTCL1	1
57410	SCYL1	2
3791	KDR	1
93210	PGAP3	6
114788	CSMD3	2
54498	SMOX	3
3000	GUCY2D	3
4086	SMAD1	1
2133	EXT3	3
572	BAD	3
5585	PKN1	3
9639	ARHGEF10	2
7249	TSC2	2
1019	CDK4	1
84075	FSCB	6
9967	THRAP3	3
1045	CDX2	3
105	ADARB2	2
5604	MAP2K1	1
4869	NPM1	3
1555	CYP2B6	2
5600	MAPK11	6
55437	STRADB	2
2309	FOXO3	6
7038	TG	3
369	ARAF	1
4921	DDR2	3
3572	IL6ST	7
57188	ADAMTSL3	2
65125	WNK1	3
4436	MSH2	2
6035	RNASE1	3
676	BRDT	3
984	CDK11B	4
5871	MAP4K2	6
5608	MAP2K6	3
80205	CHD9	2
84181	CHD6	1
57578	UNC79	3
8997	KALRN	14
4437	MSH3	3
23269	MGA	1
3643	INSR	3
2175	FANCA	1
5371	PML	6
23469	PHF3	2
4089	SMAD4	3
170692	ADAMTS18	4
54658	UGT1A1	1
6654	SOS1	6
11168	PSIP1	3
10948	STARD3	5
1848	DUSP6	6
4139	MARK1	3
7204	TRIO	3
10733	PLK4	1
5727	PTCH1	4
9448	MAP4K4	3
285220	EPHA6	3
546	ATRX	2
51366	UBR5	3
5606	MAP2K3	3
5297	PI4KA	2
1978	EIF4EBP1	1
64840	PORCN	5
30827	CXXC1	3
4214	MAP3K1	4
3702	ITK	2
3239	HOXD13	4
84823	LMNB2	3
5290	PIK3CA	2
5034	P4HB	5
1000	CDH2	2
4145	MATK	3
1687	GSDME	2
8202	NCOA3	3
4293	MAP3K9	3
26524	LATS2	2
5045	FURIN	2
64919	BCL11B	5
57154	SMURF1	5
675	BRCA2	2
26166	RGS22	2
607	BCL9	3
4803	NGF	1
138429	PIP5KL1	3
1956	EGFR	1
8445	DYRK2	3
640	BLK	3
157680	VPS13B	1
841	CASP8	5
2735	GLI1	4
3065	HDAC1	6
4609	MYC	16
64333	ARHGAP9	3
64750	SMURF2	2
2624	GATA2	2
91	ACVR1B	2
5789	PTPRD	3
5155	PDGFB	6
10461	MERTK	3
51321	AMZ2	1
1326	MAP3K8	3
8795	TNFRSF10B	1
4684	NCAM1	2
6885	MAP3K7	3
894	CCND2	6
5462	POU5F1B	3
1440	CSF3	11
79759	ZNF668	2
3553	IL1B	3
5592	PRKG1	3
1594	CYP27B1	2
1022	CDK7	3
3635	INPP5D	5
5187	PER1	1
7917	BAG6	3
375056	MIA3	2
91754	NEK9	3
93627	TBCK	2
9159	PCSK7	3
27330	RPS6KA6	1
7132	TNFRSF1A	6
7189	TRAF6	2
3949	LDLR	3
6872	TAF1	3
7153	TOP2A	2
84630	TTBK1	2
1981	EIF4G1	1
4790	NFKB1	3
84879	MFSD2A	3
22976	PAXIP1	2
780	DDR1	2
83452	RAB33B	5
8924	HERC2	2
120892	LRRK2	3
89795	NAV3	2
65268	WNK2	4
79184	BRCC3	2
6095	RORA	8
29844	TFPT	2
84441	MAML2	4
7468	NSD2	6
8029	CUBN	2
4298	MLLT1	5
11262	SP140	2
1230	CCR1	3
3229	HOXC13	3
23396	PIP5K1C	1
10010	TANK	3
1806	DPYD	3
51330	TNFRSF12A	3
22883	CLSTN1	4
667	DST	4
284086	NEK8	2
83666	PARP9	3
1613	DAPK3	2
6146	RPL22	1
1676	DFFA	6
2870	GRK6	1
28954	REM1	2
7273	TTN	4
91807	MYLK3	2
79834	PEAK1	3
995	CDC25C	3
7059	THBS3	2
7454	WAS	3
8667	EIF3H	3
54904	NSD3	4
23411	SIRT1	4
53904	MYO3A	2
8648	NCOA1	3
29941	PKN3	2
79012	CAMKV	2
55561	CDC42BPG	2
2046	EPHA8	2
9943	OXSR1	3
2353	FOS	2
286151	FBXO43	2
57820	CCNB1IP1	3
344905	ATP13A5	8
4297	KMT2A	2
3611	ILK	3
558	AXL	2
7248	TSC1	2
126792	B3GALT6	2
9748	SLK	2
4619	MYH1	4
5581	PRKCE	4
5923	RASGRF1	3
5562	PRKAA1	3
2690	GHR	2
2317	FLNB	1
10111	RAD50	4
100124696	TEC	3
6790	AURKA	2
9223	MAGI1	6
860	RUNX2	3
778	CACNA1F	2
171389	NLRP6	2
55289	ACOXL	5
5609	MAP2K7	3
1281	COL3A1	1
9659	PDE4DIP	2
9201	DCLK1	1
63976	PRDM16	2
5335	PLCG1	3
131890	GRK7	2
2194	FASN	5
598	BCL2L1	2
1719	DHFR	6
5583	PRKCH	3
5589	PRKCSH	2
5170	PDPK1	7
57448	BIRC6	2
2304	FOXE1	3
22982	DIP2C	3
7227	TRPS1	5
53335	BCL11A	3
5506	PPP1R3A	3
1627	DBN1	3
79837	PIP4K2C	2
57147	SCYL3	3
6778	STAT6	3
1906	EDN1	3
8899	PRPF4B	5
6194	RPS6	3
1030	CDKN2B	1
65267	WNK3	3
3984	LIMK1	2
8428	STK24	3
3516	RBPJ	3
3977	LIFR	1
3656	IRAK2	3
4330	MN1	2
84072	HORMAD1	4
23512	SUZ12	3
5894	RAF1	1
23250	ATP11A	6
182	JAG1	5
2122	MECOM	4
3662	IRF4	2
9894	TELO2	3
2903	GRIN2A	3
4974	OMG	3
5925	RB1	2
4217	MAP3K5	3
7069	THRSP	3
5584	PRKCI	2
1026	CDKN1A	3
2065	ERBB3	4
7403	KDM6A	1
4615	MYD88	3
4638	MYLK	3
4205	MEF2A	6
30849	PIK3R4	2
55959	SULF2	3
171017	ZNF384	3
3488	IGFBP5	2
2011	MARK2	3
10494	STK25	6
11086	ADAM29	5
142	PARP1	1
2261	FGFR3	6
5567	PRKACB	3
4040	LRP6	2
55422	ZNF331	8
3092	HIP1	3
4763	NF1	2
57697	FANCM	2
5260	PHKG1	3
138474	TAF1L	7
9625	AATK	3
1994	ELAVL1	7
63893	UBE2O	5
1840	DTX1	2
10891	PPARGC1A	1
57096	RPGRIP1	3
23031	MAST3	3
1608	DGKG	1
7294	TXK	3
1803	DPP4	1
1499	CTNNB1	1
27151	CPAMD8	2
3440	IFNA2	2
4916	NTRK3	2
2886	GRB7	4
167359	NIM1K	1
4486	MST1R	4
5624	PROC	5
5970	RELA	2

Gene in drug-gene network: Network Plot

Models in SB225002

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.