MST1R
Summary: This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600168 Ensembl IDEnsembl:ENSG00000164078 HGNC IDHGNC:HGNC:7381 PHARMGKB IDPA31186 Map Location3p21.31 | |||||
GO terms in MST1R
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | TAS | GO:0005011 | macrophage colony-stimulating factor receptor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: MST1R
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MST1R
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | amb2_neutrophils_pathway | amb2 Integrin signaling |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-8852405 | Signaling by MST1 |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MST1R
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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