MST1R
Summary: This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| macrophage stimulating 1 receptor | MIM:600168 | Ensembl:ENSG00000164078 | HGNC:HGNC:7381 | PA31186 | 3p21.31 |
GO terms in MST1R
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | TAS | GO:0005011 | macrophage colony-stimulating factor receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0017147 | Wnt-protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| CC | IEA | GO:0001725 | stress fiber |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005773 | vacuole |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0009925 | basal plasma membrane |
| CC | HDA | GO:0009986 | cell surface |
| CC | IBA | GO:0043235 | receptor complex |
| BP | TAS | GO:0006952 | defense response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | TAS | GO:0007338 | single fertilization |
| BP | TAS | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0009615 | response to virus |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IBA | GO:0016055 | Wnt signaling pathway |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IEA | GO:0038145 | macrophage colony-stimulating factor signaling pathway |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IEA | GO:0045087 | innate immune response |
| BP | TAS | GO:0048012 | hepatocyte growth factor receptor signaling pathway |
| BP | IDA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
Gene expression in normal tissue: MST1R
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MST1R
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | amb2_neutrophils_pathway | amb2 Integrin signaling |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-8852405 | Signaling by MST1 |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD329 | Merck60 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD246 | NPC26 | 6 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD883 | CIL55A | 6 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD188 | Piperlongumine | 7 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD138 | PX 12 | 6 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD144 | NSC95397 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MST1R
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