MST1R


Summary: This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
macrophage stimulating 1 receptorMIM:600168Ensembl:ENSG00000164078HGNC:HGNC:7381PA311863p21.31

GO terms in MST1R


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFTASGO:0005011macrophage colony-stimulating factor receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0017147Wnt-protein binding
MFIPIGO:0019899enzyme binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
CCIEAGO:0001725stress fiber
CCIBAGO:0005737cytoplasm
CCIEAGO:0005773vacuole
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIBAGO:0009925basal plasma membrane
CCHDAGO:0009986cell surface
CCIBAGO:0043235receptor complex
BPTASGO:0006952defense response
BPTASGO:0007165signal transduction
BPIBAGO:0007275multicellular organism development
BPTASGO:0007338single fertilization
BPTASGO:0008284positive regulation of cell proliferation
BPIDAGO:0009615response to virus
BPIBAGO:0009968negative regulation of signal transduction
BPIBAGO:0016055Wnt signaling pathway
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0030154cell differentiation
BPIBAGO:0033674positive regulation of kinase activity
BPIEAGO:0038145macrophage colony-stimulating factor signaling pathway
BPIBAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043406positive regulation of MAP kinase activity
BPIBAGO:0043410positive regulation of MAPK cascade
BPIEAGO:0045087innate immune response
BPTASGO:0048012hepatocyte growth factor receptor signaling pathway
BPIDAGO:0051897positive regulation of protein kinase B signaling
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade

Gene expression in normal tissue: MST1R

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MST1R


DatabasePathway IDPathway Des.
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
pidamb2_neutrophils_pathwayamb2 Integrin signaling
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-8852405Signaling by MST1
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD329Merck603
iGMDRD286Nsc 6328393
iGMDRD871BRD63683
iGMDRD246NPC266
iGMDRD251ML1623
iGMDRD289Parthenolide3
iGMDRD705Nakiterpiosin3
iGMDRD434BMS-5369243
iGMDRD698Neratinib3
iGMDRD341Triacsin c1
iGMDRD883CIL55A6
iGMDRD945ML2146
iGMDRD123Isoevodiamine3
iGMDRD486Tosedostat1
iGMDRD150RITA3
iGMDRD506Fedratinib1
iGMDRD577BIX012946
iGMDRD188Piperlongumine7
iGMDRD887Compound 23 citrate3
iGMDRD131Erlotinib1
iGMDRD64Parbendazole6
iGMDRD255SB2250024
iGMDRD260FQI-23
iGMDRD138PX 126
iGMDRD474Avrainvillamide3
iGMDRD193Fqi16
iGMDRD446LY 21832403
iGMDRD679Bistramide A1
iGMDRD280CYTOCHALASIN B3
iGMDRD126Tipifarnib3
iGMDRD151CHM-11
iGMDRD144NSC953976

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MST1R

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