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iGMDRD131

Canonical SMILES: COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC

InChI: InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)

InChI Key: AAKJLRGGTJKAMG-UHFFFAOYSA-N

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Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Standard NameErlotinib CHEMBLCHEMBL553 CHEMBL1079742 Pubchem CID176870 KEGG Drug IDD07907 DRUGBANK IDDB00530 Drug StatusAlone Drug targets (TTD)DAP001010 Drug TypeSmall Molecule

Drug Class:

Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 2-Ring Kinase Inhibitor P-glycoprotein/ABCB1 Inhibitors P-glycoprotein/ABCB1 Substrates Protein Kinase Inhibitors Quinazolines Tyrosine Kinase Inhibitors UGT1A1 Inhibitors

Drug Targets:

EGFR (P00533)NR1I2 (O75469)

Drug Pathways:

EGFR signaling MAPK signaling pathway ErbB signaling pathway Pathways in cancer Pancreatic cancer Non-small cell lung cancer

Drug Synonyms:

Erlotinib (INN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

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Gene ID	Gene Name	Model Num.
123036	TC2N	1
2352	FOLR3	1
100507632	LINC00968	1
150696	PROM2	1

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Gene in drug-gene network: Network Plot

Models in Erlotinib

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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