iGMDRD131
| Standard Name | CHEMBL | Pubchem CID | KEGG Drug ID | DRUGBANK ID | Drug Status | Drug targets (TTD) | Drug Type |
|---|---|---|---|---|---|---|---|
| Erlotinib | CHEMBL553 CHEMBL1079742 | 176870 | D07907 | DB00530 | Alone | DAP001010 | Small Molecule |
Drug Class:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 InhibitorsCytochrome P-450 CYP1A2 SubstratesCytochrome P-450 Enzyme InhibitorsEnzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 2-RingKinase InhibitorP-glycoprotein/ABCB1 InhibitorsP-glycoprotein/ABCB1 SubstratesProtein Kinase InhibitorsQuinazolinesTyrosine Kinase InhibitorsUGT1A1 InhibitorsDrug Pathways:
EGFR signalingMAPK signaling pathwayErbB signaling pathwayPathways in cancerPancreatic cancerNon-small cell lung cancerDrug Synonyms:
Erlotinib (INN)Drug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
| Gene ID | Gene Name | Model Num. |
|---|---|---|
| 123036 | TC2N | 1 |
| 2352 | FOLR3 | 1 |
| 100507632 | LINC00968 | 1 |
| 150696 | PROM2 | 1 |
| 9379 | NRXN2 | 1 |
| 259173 | ALS2CL | 1 |
| 11202 | KLK8 | 1 |
| 253012 | HEPACAM2 | 1 |
| 3845 | KRAS | 7 |
| 250 | ALPP | 1 |
| 8289 | ARID1A | 1 |
| 285973 | ATG9B | 1 |
| 100130265 | ARL2BPP4 | 1 |
| 79092 | CARD14 | 1 |
| 6597 | SMARCA4 | 1 |
| 4771 | NF2 | 5 |
| 3694 | ITGB6 | 2 |
| 374860 | ANKRD30B | 1 |
| 3775 | KCNK1 | 1 |
| 9757 | KMT2B | 1 |
| 266977 | ADGRF1 | 1 |
| 56164 | STK31 | 1 |
| 4070 | TACSTD2 | 2 |
| 11200 | CHEK2 | 2 |
| 101927528 | LINC01204 | 1 |
| 1114 | CHGB | 1 |
| 5159 | PDGFRB | 1 |
| 4610 | MYCL | 1 |
| 25937 | WWTR1 | 1 |
| 6538 | SLC6A11 | 1 |
| 2707 | GJB3 | 2 |
| 4300 | MLLT3 | 1 |
| 56603 | CYP26B1 | 1 |
| 219855 | SLC37A2 | 2 |
| 29785 | CYP2S1 | 1 |
| 9721 | GPRIN2 | 1 |
| 146439 | BICDL2 | 1 |
| 728113 | ANXA8L1 | 1 |
| 2064 | ERBB2 | 3 |
| 60676 | PAPPA2 | 1 |
| 6850 | SYK | 1 |
| 92369 | SPSB4 | 1 |
| 22941 | SHANK2 | 1 |
| 2050 | EPHB4 | 1 |
| 94025 | MUC16 | 2 |
| 10413 | YAP1 | 1 |
| 1029 | CDKN2A | 2 |
| 7157 | TP53 | 1 |
| 775 | CACNA1C | 1 |
| 6794 | STK11 | 2 |
| 3791 | KDR | 1 |
| 4292 | MLH1 | 1 |
| 7379 | UPK2 | 1 |
| 93099 | DMKN | 1 |
| 4921 | DDR2 | 3 |
| 8796 | SCEL | 1 |
| 57188 | ADAMTSL3 | 1 |
| 251 | ALPG | 1 |
| 57111 | RAB25 | 1 |
| 4089 | SMAD4 | 2 |
| 9245 | GCNT3 | 1 |
| 8731 | RNMT | 2 |
| 5290 | PIK3CA | 2 |
| 79679 | VTCN1 | 1 |
| 106479795 | RNU6-517P | 1 |
| 1956 | EGFR | 199 |
| 4609 | MYC | 1 |
| 54206 | ERRFI1 | 1 |
| 1031 | CDKN2C | 1 |
| 673 | BRAF | 1 |
| 440799 | P2RX6P | 1 |
| 1938 | EEF2 | 1 |
| 5205 | ATP8B1 | 1 |
| 116113 | FOXP4 | 1 |
| 30818 | KCNIP3 | 1 |
| 5728 | PTEN | 3 |
| 2036 | EPB41L1 | 2 |
| 5594 | MAPK1 | 1 |
| 28232 | SLCO3A1 | 1 |
| 55738 | ARFGAP1 | 1 |
| 6707 | SPRR3 | 1 |
| 2564 | GABRE | 1 |
| 8821 | INPP4B | 2 |
| 84951 | TNS4 | 1 |
| 54101 | RIPK4 | 1 |
| 147700 | KLC3 | 2 |
| 56169 | GSDMC | 2 |
| 100862685 | ERVK-19 | 1 |
| 219348 | PLAC9 | 1 |
| 5925 | RB1 | 1 |
| 4893 | NRAS | 2 |
| 51442 | VGLL1 | 1 |
| 3691 | ITGB4 | 1 |
| 7403 | KDM6A | 1 |
| 3480 | IGF1R | 2 |
| 23017 | FAIM2 | 1 |
| 100240709 | GAPDHP44 | 1 |
| 8711 | TNK1 | 1 |
| 1013 | CDH15 | 1 |
| 595 | CCND1 | 2 |
| 4763 | NF1 | 8 |
| 7022 | TFAP2C | 1 |
| 4613 | MYCN | 2 |
| 9076 | CLDN1 | 2 |
| 1499 | CTNNB1 | 2 |
| 4486 | MST1R | 1 |
| 5624 | PROC | 1 |
| 374378 | GALNT18 | 1 |
Gene in drug-gene network: Network Plot
Models in Erlotinib
CLASSFICATION
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