HEPACAM2
Summary: This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. [provided by RefSeq, Oct 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| HEPACAM family member 2 | MIM:614133 | Ensembl:ENSG00000188175 | HGNC:HGNC:27364 | PA162390849 | 7q21.2 |
GO terms in HEPACAM2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | IBA | GO:0005819 | spindle |
| CC | IDA | GO:0005819 | spindle |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0030496 | midbody |
| CC | IDA | GO:0030496 | midbody |
| BP | IBA | GO:0007098 | centrosome cycle |
| BP | IMP | GO:0007098 | centrosome cycle |
| BP | IEA | GO:0051301 | cell division |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: HEPACAM2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HEPACAM2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HEPACAM2
CLASSFICATION
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