HEPACAM2


Summary: This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. [provided by RefSeq, Oct 2016].

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GO terms in HEPACAM2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0000139 Golgi membrane
CC IBA GO:0005794 Golgi apparatus
CC IDA GO:0005794 Golgi apparatus
CC IBA GO:0005813 centrosome
CC IDA GO:0005813 centrosome
CC IBA GO:0005819 spindle
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Gene expression in normal tissue: HEPACAM2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1EGFR signaling1

Pathways in HEPACAM2


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD131 Erlotinib 1
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HEPACAM2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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