GO terms in WWTR1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001649osteoblast differentiation
BPIEAGO:0001894tissue homeostasis
BPIMPGO:0001933negative regulation of protein phosphorylation
BPIEAGO:0003015heart process
BPNASGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIMPGO:0006469negative regulation of protein kinase activity
BPIDAGO:0008284positive regulation of cell proliferation
BPIDAGO:0010718positive regulation of epithelial to mesenchymal transition
BPIEAGO:0016567protein ubiquitination
BPIDAGO:0017145stem cell division
BPIEAGO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
BPIEAGO:0032835glomerulus development
BPIEAGO:0035264multicellular organism growth
BPIDAGO:0035329hippo signaling
BPTASGO:0035329hippo signaling
BPIEAGO:0045599negative regulation of fat cell differentiation
BPTASGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048762mesenchymal cell differentiation
BPIEAGO:0060271cilium assembly
BPIDAGO:0060390regulation of SMAD protein signal transduction
BPIEAGO:0060993kidney morphogenesis
BPIEAGO:0072307regulation of metanephric nephron tubule epithelial cell differentiation
BPIMPGO:0090090negative regulation of canonical Wnt signaling pathway
CCIDAGO:0005634nucleus
CCNASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005667transcription factor complex
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0016604nuclear body
MFIDAGO:0003713transcription coactivator activity
MFNASGO:0003713transcription coactivator activity
MFIEAGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIEAGO:0042803protein homodimerization activity

Gene expression in normal tissue: WWTR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in WWTR1


DatabasePathway IDPathway Des.
wikipathwaysWP236Adipogenesis
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04392Hippo signaling pathway - multiple species - Homo sapiens (human)
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-2028269Signaling by Hippo
reactomeR-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expression
reactomeR-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expression
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
reactomeR-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5578768Physiological factors
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8940973RUNX2 regulates osteoblast differentiation
reactomeR-HSA-8941326RUNX2 regulates bone development
reactomeR-HSA-8951671RUNX3 regulates YAP1-mediated transcription
reactomeR-HSA-9006936Signaling by TGF-beta family members

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD251ML1621
iGMDRD467Motesanib1
iGMDRD311Dacinostat1
iGMDRD327LBH-5891
iGMDRD561ABT-2631
iGMDRD245FH5351
iGMDRD264Bryostatin 11
iGMDRD324CI-10401
iGMDRD20Embelin1
iGMDRD50Cytarabine1
iGMDRD15Tacedinaline1
iGMDRD352PD-03259011
iGMDRD314Tanespimycin1
iGMDRD170Fluvastatin1
iGMDRD698Neratinib1
iGMDRD605AZD64821
iGMDRD117Docetaxel1
iGMDRD468AZ6281
iGMDRD133Lapatinib1
iGMDRD641SCH 797971
iGMDRD146Elesclomol1
iGMDRD431NU-74411
iGMDRD549Ibrutinib (PCI-32765)1
iGMDRD546BMS-7548071
iGMDRD476WH-4-0231
iGMDRD670ML 2101
iGMDRD397Pazopanib1
iGMDRD75Lovastatin1
iGMDRD793BEC (hydrochloride)1
iGMDRD21Fluorouracil1
iGMDRD124Canertinib1
iGMDRD479Veliparib1
iGMDRD88AICA ribonucleotide1
iGMDRD551Ponatinib1
iGMDRD472PF-5622711
iGMDRD42Vorinostat1
iGMDRD353PD03259012
iGMDRD125BIRB-7961
iGMDRD614Dabrafenib1
iGMDRD160Cis-Platin1
iGMDRD452PF-5732281
iGMDRD536PLX-47201
iGMDRD450JNJ-268541651
iGMDRD595PLX40321
iGMDRD480KU00606482
iGMDRD109Gefitinib1
iGMDRD573GSK-1904529A1
iGMDRD478ABT-8881
iGMDRD441TW 371
iGMDRD318PAC-11
iGMDRD325Belinostat1
iGMDRD887Compound 23 citrate1
iGMDRD131Erlotinib1
iGMDRD454JNK Inhibitor VIII1
iGMDRD371THR1 Inhibitor1
iGMDRD97Bexarotene1
iGMDRD387CHIR-990211
iGMDRD63Camptothecin1
iGMDRD239Dasatinib1
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD129SB-2167631
iGMDRD354Midostaurin1
iGMDRD519GDC-09411
iGMDRD608Refametinib1
iGMDRD498GW441756X1
iGMDRD297Austocystin D1
iGMDRD401Afatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in WWTR1

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