iGMDRD354

Canonical SMILES: CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC

InChI: InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1

InChI Key: BMGQWWVMWDBQGC-IIFHNQTCSA-N

Loading, please wait...
Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameMidostaurin
CHEMBLCHEMBL608533
Pubchem CID9829520
DRUGBANK IDDB06595
Drug StatusAlone
Drug TypeSmall Molecule

Drug Class:

AlkaloidsAntineoplastic AgentsCarbazolesCytochrome P-450 CYP1A2 InhibitorsCytochrome P-450 CYP1A2 Inhibitors (strong)Cytochrome P-450 CYP2C9 InhibitorsCytochrome P-450 CYP2C9 Inhibitors (strong)Cytochrome P-450 CYP2D6 InhibitorsCytochrome P-450 CYP2D6 Inhibitors (strong)Cytochrome P-450 CYP2E1 InhibitorsCytochrome P-450 CYP2E1 Inhibitors (strong)Cytochrome P-450 CYP3A InducersCytochrome P-450 CYP3A Inducers (strong)Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A Inhibitors (strong)Cytochrome P-450 Enzyme InducersCytochrome P-450 Enzyme InhibitorsEnzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 2-RingHeterocyclic Compounds, 3-RingIndole AlkaloidsIndolesKinase InhibitorProtein Kinase C, antagonists & inhibitorsProtein Kinase InhibitorsVascular Endothelial Growth Factor Receptor 2 Antagonist

Drug-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 10BREASTtissue: BREAST cancer: Invasive Breast Carcinoma (BRCA) model num: 2BREASTtissue: BREAST cancer: Breast Carcinoma model num: 2OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 2BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 2BLOODtissue: BLOOD cancer: Acute Myeloid Leukemia (AML) model num: 5BLOODtissue: BLOOD cancer: Myeloproliferative Neoplasm (MPN) model num: 1BLOODtissue: BLOOD cancer: Systemic Mastocytosis (SM) model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 28BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Adenocarcinoma (LUAD) model num: 1

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Loading, please wait...
Gene ID
Gene Name
Model Num.
7514 XPO1 1
6774 STAT3 1
390502 SERPINA2 1
2625 GATA3 1
Showing 1 to 4 of 23 rows rows per page

Gene in drug-gene network: Network Plot

Models in Midostaurin

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.