iGMDRD354

Canonical SMILES: CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC

InChI: InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1

InChI Key: BMGQWWVMWDBQGC-IIFHNQTCSA-N

Standard NameCHEMBLPubchem CIDDRUGBANK IDDrug StatusDrug Type
MidostaurinCHEMBL608533 9829520DB06595AloneSmall Molecule

Drug Class:

AlkaloidsAntineoplastic AgentsCarbazolesCytochrome P-450 CYP1A2 InhibitorsCytochrome P-450 CYP1A2 Inhibitors (strong)Cytochrome P-450 CYP2C9 InhibitorsCytochrome P-450 CYP2C9 Inhibitors (strong)Cytochrome P-450 CYP2D6 InhibitorsCytochrome P-450 CYP2D6 Inhibitors (strong)Cytochrome P-450 CYP2E1 InhibitorsCytochrome P-450 CYP2E1 Inhibitors (strong)Cytochrome P-450 CYP3A InducersCytochrome P-450 CYP3A Inducers (strong)Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A Inhibitors (strong)Cytochrome P-450 Enzyme InducersCytochrome P-450 Enzyme InhibitorsEnzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 2-RingHeterocyclic Compounds, 3-RingIndole AlkaloidsIndolesKinase InhibitorProtein Kinase C, antagonists & inhibitorsProtein Kinase InhibitorsVascular Endothelial Growth Factor Receptor 2 Antagonist

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
7514XPO11
6774STAT31
390502SERPINA21
2625GATA31
7307U2AF11
4610MYCL1
25937WWTR11
2064ERBB21
6850SYK1
1029CDKN2A1
4088SMAD31
2322FLT36
3791KDR1
4904YBX11
1956EGFR1
54206ERRFI11
673BRAF1
2113ETS11
2067ERCC11
2194FASN1
100862685ERVK-191
3815KIT1
5054SERPINE11

Gene in drug-gene network: Network Plot

Models in Midostaurin

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.