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FLT3

Summary: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
fms related tyrosine kinase 3	MIM:136351	Ensembl:ENSG00000122025	HGNC:HGNC:3765	PA28181	13q12.2

Gene Categories:

TYROSINE KINASE LIPID KINASE DRUGGABLE GENOME CLINICALLY ACTIONABLE KINASE SERINE THREONINE KINASE

GO terms in FLT3

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004709	MAP kinase kinase kinase activity
MF	IBA	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	TAS	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	IBA	GO:0004888	transmembrane signaling receptor activity
MF	ISS	GO:0004896	cytokine receptor activity
MF	TAS	GO:0005021	vascular endothelial growth factor-activated receptor activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IBA	GO:0019838	growth factor binding
MF	IBA	GO:0031434	mitogen-activated protein kinase kinase binding
MF	IEA	GO:0035259	glucocorticoid receptor binding
MF	TAS	GO:0042803	protein homodimerization activity
MF	IMP	GO:0043621	protein self-association
MF	IEA	GO:0044877	protein-containing complex binding
CC	IEA	GO:0005634	nucleus
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005783	endoplasmic reticulum
CC	IEA	GO:0005788	endoplasmic reticulum lumen
CC	IEA	GO:0005829	cytosol
CC	TAS	GO:0005886	plasma membrane
CC	IBA	GO:0005887	integral component of plasma membrane
CC	TAS	GO:0005887	integral component of plasma membrane
CC	IEA	GO:0032991	protein-containing complex
CC	IBA	GO:0043235	receptor complex
BP	ISS	GO:0001776	leukocyte homeostasis
BP	ISS	GO:0002318	myeloid progenitor cell differentiation
BP	ISS	GO:0002328	pro-B cell differentiation
BP	TAS	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	IBA	GO:0007275	multicellular organism development
BP	TAS	GO:0008284	positive regulation of cell proliferation
BP	IBA	GO:0009968	negative regulation of signal transduction
BP	IEA	GO:0010243	response to organonitrogen compound
BP	TAS	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
BP	TAS	GO:0018108	peptidyl-tyrosine phosphorylation
BP	ISS	GO:0019221	cytokine-mediated signaling pathway
BP	TAS	GO:0019221	cytokine-mediated signaling pathway
BP	IDA	GO:0030097	hemopoiesis
BP	IBA	GO:0030154	cell differentiation
BP	ISS	GO:0030183	B cell differentiation
BP	IEA	GO:0031100	animal organ regeneration
BP	IBA	GO:0033674	positive regulation of kinase activity
BP	ISS	GO:0035726	common myeloid progenitor cell proliferation
BP	IEA	GO:0038084	vascular endothelial growth factor signaling pathway
BP	TAS	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
BP	TAS	GO:0042981	regulation of apoptotic process
BP	IBA	GO:0043066	negative regulation of apoptotic process
BP	TAS	GO:0043406	positive regulation of MAP kinase activity
BP	IBA	GO:0043410	positive regulation of MAPK cascade
BP	TAS	GO:0043410	positive regulation of MAPK cascade
BP	TAS	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
BP	ISS	GO:0046651	lymphocyte proliferation
BP	TAS	GO:0046777	protein autophosphorylation
BP	IBA	GO:0070374	positive regulation of ERK1 and ERK2 cascade
BP	ISS	GO:0071345	cellular response to cytokine stimulus
BP	TAS	GO:0071345	cellular response to cytokine stimulus
BP	IEA	GO:0071385	cellular response to glucocorticoid stimulus
BP	ISS	GO:0097028	dendritic cell differentiation

Gene expression in normal tissue: FLT3

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FLT3

Database	Pathway ID	Pathway Des.
reactome	R-HSA-109704	PI3K Cascade
reactome	R-HSA-112399	IRS-mediated signalling
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-168256	Immune System
reactome	R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactome	R-HSA-2428924	IGF1R signaling cascade
reactome	R-HSA-2428928	IRS-related events triggered by IGF1R
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-449836	Other interleukin signaling
reactome	R-HSA-5673001	RAF/MAP kinase cascade
reactome	R-HSA-5683057	MAPK family signaling cascades
reactome	R-HSA-5684996	MAPK1/MAPK3 signaling
reactome	R-HSA-74751	Insulin receptor signalling cascade
reactome	R-HSA-74752	Signaling by Insulin receptor
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
wikipathways	WP3657	Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex
wikipathways	WP3658	Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathways	WP4172	PI3K-Akt Signaling Pathway
wikipathways	WP4223	Ras Signaling
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04014	Ras signaling pathway - Homo sapiens (human)
kegg	hsa04060	Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa04640	Hematopoietic cell lineage - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05202	Transcriptional misregulation in cancer - Homo sapiens (human)
kegg	hsa05221	Acute myeloid leukemia - Homo sapiens (human)
kegg	hsa05230	Central carbon metabolism in cancer - Homo sapiens (human)
pharmgkb	PA165959425	Pathway_PA165959425
pharmgkb	PA165959584	Sorafenib Pharmacodynamics

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD332	A-770041	1
iGMDRD60	Quinoclamine	2
iGMDRD677	ABT-199 (GDC-0199)	1
iGMDRD138	PX 12	1
iGMDRD491	TAE-684	1
iGMDRD913	FLT3 inhibitor	2
iGMDRD413	Crenolanib	2
iGMDRD134	Sorafenib	22
iGMDRD318	PAC-1	2
iGMDRD440	Nutlin-3A	1
iGMDRD885	Compound 110	2
iGMDRD388	YM201636	1
iGMDRD446	LY 2183240	1
iGMDRD498	GW441756X	1
iGMDRD163	all trans Retinoic Acid	1
iGMDRD297	Austocystin D	2
iGMDRD378	ZM-447439	2
iGMDRD1008	SR-II-138A	2
iGMDRD144	NSC95397	2
iGMDRD354	Midostaurin	6
iGMDRD3	PD-173074	1
iGMDRD269	Purmorphamine	3
iGMDRD472	PF-562271	1
iGMDRD505	Pevonedistat	2
iGMDRD556	Quizartinib	24
iGMDRD56	Azacitidine	2
iGMDRD515	Staurosporine	2
iGMDRD434	BMS-536924	2
iGMDRD241	Sunitinib	5
iGMDRD481	Dactolisib	1
iGMDRD267	Oligomycin A	1
iGMDRD551	Ponatinib	6
iGMDRD177	Teniposide	3
iGMDRD382	CEP-701	2
iGMDRD307	Manumycin A	2
iGMDRD125	BIRB-796	1
iGMDRD116	CD437	2
iGMDRD424	Tamatinib	2
iGMDRD188	Piperlongumine	2
iGMDRD4	AG-1296	1
iGMDRD399	Selumetinib	4
iGMDRD23	Gossypol	3
iGMDRD568	SCHEMBL15005512	1
iGMDRD493	GSK269962A	1
iGMDRD294	Batimastat	3
iGMDRD394	BX-795	1
iGMDRD694	HG6-64-1	1
iGMDRD126	Tipifarnib	1
iGMDRD1034	WZ3105	1
iGMDRD433	Lexibulin	3
iGMDRD571	Cabozantinib	2
iGMDRD443	Linifanib	1
iGMDRD654	SL 0101-1	1
iGMDRD476	WH-4-023	1
iGMDRD329	Merck60	5
iGMDRD421	AZD7762	2
iGMDRD158	NSC141540	2
iGMDRD202	Curcumin	6
iGMDRD705	Nakiterpiosin	2
iGMDRD77	Itraconazole	2
iGMDRD65	Daunorubicin	2
iGMDRD564	GSK-650394	1
iGMDRD961	novel FLT3 inhibitor	2
iGMDRD315	SU-5614	2
iGMDRD162	All-trans Retinoic Acid	2
iGMDRD111	Lestaurtinib	2
iGMDRD523	Cyanoquinoline, 11	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FLT3

SITE

DATATYPES

CLASSFICATION

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