XPO1
Summary: This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameexportin 1 OMIM IDMIM:602559 Ensembl IDEnsembl:ENSG00000082898 HGNC IDHGNC:HGNC:12825 PHARMGKB IDPA37418 Map Location2p15 | |||||
GO terms in XPO1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000054 | ribosomal subunit export from nucleus |
| BP | IBA | GO:0000055 | ribosomal large subunit export from nucleus |
| BP | IMP | GO:0000055 | ribosomal large subunit export from nucleus |
| BP | IBA | GO:0000056 | ribosomal small subunit export from nucleus |
| BP | IMP | GO:0000056 | ribosomal small subunit export from nucleus |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
Gene expression in normal tissue: XPO1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in XPO1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in XPO1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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