XPO1
Summary: This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| exportin 1 | MIM:602559 | Ensembl:ENSG00000082898 | HGNC:HGNC:12825 | PA37418 | 2p15 |
GO terms in XPO1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000054 | ribosomal subunit export from nucleus |
| BP | IBA | GO:0000055 | ribosomal large subunit export from nucleus |
| BP | IMP | GO:0000055 | ribosomal large subunit export from nucleus |
| BP | IBA | GO:0000056 | ribosomal small subunit export from nucleus |
| BP | IMP | GO:0000056 | ribosomal small subunit export from nucleus |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IC | GO:0006611 | protein export from nucleus |
| BP | IDA | GO:0006611 | protein export from nucleus |
| BP | IMP | GO:0006611 | protein export from nucleus |
| BP | IMP | GO:0006913 | nucleocytoplasmic transport |
| BP | IEA | GO:0010824 | regulation of centrosome duplication |
| BP | TAS | GO:0016032 | viral process |
| BP | IEA | GO:0034504 | protein localization to nucleus |
| BP | IEA | GO:0042176 | regulation of protein catabolic process |
| BP | IMP | GO:0042254 | ribosome biogenesis |
| BP | IEA | GO:0042493 | response to drug |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | IBA | GO:0046825 | regulation of protein export from nucleus |
| BP | IEA | GO:0051028 | mRNA transport |
| BP | TAS | GO:0075733 | intracellular transport of virus |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005635 | nuclear envelope |
| CC | IDA | GO:0005642 | annulate lamellae |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0015030 | Cajal body |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0031965 | nuclear membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:0043657 | host cell |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
| MF | IEA | GO:0003723 | RNA binding |
| MF | IBA | GO:0005049 | nuclear export signal receptor activity |
| MF | IMP | GO:0005049 | nuclear export signal receptor activity |
| MF | TAS | GO:0005215 | transporter activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008536 | Ran GTPase binding |
| MF | IEA | GO:0008565 | protein transporter activity |
| MF | IEA | GO:0019904 | protein domain specific binding |
Gene expression in normal tissue: XPO1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in XPO1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-165054 | Rev-mediated nuclear export of HIV RNA |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus |
| reactome | R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-2173788 | Downregulation of TGF-beta receptor signaling |
| reactome | R-HSA-2173789 | TGF-beta receptor signaling activates SMADs |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| reactome | R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| biocarta | crempathway | regulation of spermatogenesis by crem |
| biocarta | ptc1pathway | sonic hedgehog receptor ptc1 regulates cell cycle |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | foxopathway | FoxO family signaling |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| pid | ranbp2pathway | Sumoylation by RanBP2 regulates transcriptional repression |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| kegg | hsa03008 | Ribosome biogenesis in eukaryotes - Homo sapiens (human) |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| wikipathways | WP3302 | eIF5A regulation in response to inhibition of the nuclear export system |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD401 | Afatinib | 1 |
| iGMDRD348 | BMS-345541 | 1 |
| iGMDRD235 | SNS-032 | 1 |
| iGMDRD258 | SB-431542 | 1 |
| iGMDRD78 | Topotecan | 1 |
| iGMDRD63 | Camptothecin | 1 |
| iGMDRD313 | Axitinib | 1 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD229 | B02 | 1 |
| iGMDRD145 | Omacetaxine mepesuccinate | 1 |
| iGMDRD55 | Pyrazolanthrone | 1 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD422 | Regorafenib | 1 |
| iGMDRD613 | CHEMBL258148 | 1 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD750 | TRIAZOLOTHIADIAZINE | 1 |
| iGMDRD204 | Necrostatin-7 | 1 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD178 | MG-132 | 1 |
| iGMDRD14 | Chlorambucil | 1 |
| iGMDRD456 | Crizotinib | 1 |
| iGMDRD256 | NVP-231 | 1 |
| iGMDRD798 | Ceranib-2 | 1 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD404 | PD318088 | 1 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD495 | XL765 | 1 |
| iGMDRD153 | Bardoxolone methyl | 1 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD990 | PL.DI | 1 |
| iGMDRD646 | PHA-793887 | 1 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD241 | Sunitinib | 1 |
| iGMDRD415 | LE-135 | 1 |
| iGMDRD504 | Obatoclax | 1 |
| iGMDRD68 | Paclitaxel | 2 |
| iGMDRD746 | CDK9 Inhibitor | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD549 | Ibrutinib (PCI-32765) | 1 |
| iGMDRD283 | Bosutinib | 1 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD937 | KIN001-236 | 1 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD431 | NU-7441 | 1 |
| iGMDRD641 | SCH 79797 | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD323 | Leptomycin B | 1 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD1038 | X3.Cl.AHPC | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD106 | Clofarabine | 1 |
| iGMDRD272 | GSK-3 Inhibitor IX | 1 |
| iGMDRD176 | Decitabine | 1 |
| iGMDRD321 | Daporinad | 1 |
| iGMDRD703 | KPT185 | 1 |
| iGMDRD423 | AT 7867 | 1 |
| iGMDRD370 | TPCA-1 | 1 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD156 | HLI-373 | 1 |
| iGMDRD787 | PF 184 | 2 |
| iGMDRD380 | Pifithrin-alpha | 1 |
| iGMDRD591 | PF-3758309 | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD66 | Doxorubicin | 1 |
| iGMDRD144 | NSC95397 | 1 |
| iGMDRD354 | Midostaurin | 1 |
| iGMDRD489 | GSK-461364 | 2 |
| iGMDRD857 | BRD-K70511574 | 1 |
| iGMDRD640 | CAY10618 | 1 |
| iGMDRD533 | HSCI1_000270 | 1 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD287 | Myricetin | 1 |
| iGMDRD473 | GDC-0879 | 1 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD852 | BRD-K35604418 | 1 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD346 | Nintedanib | 1 |
| iGMDRD435 | BI-2536 | 2 |
| iGMDRD426 | WP1130 | 1 |
| iGMDRD689 | EX-8678 | 1 |
| iGMDRD452 | PF-573228 | 1 |
| iGMDRD317 | CCT 018159 | 1 |
| iGMDRD765 | BRD-K51490254 | 1 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD717 | COL-3 | 1 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD582 | MLN 2238 | 1 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD379 | BIBR-1532 | 1 |
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD231 | Importazole | 1 |
| iGMDRD157 | Ouabain | 1 |
| iGMDRD385 | CD1530 | 1 |
| iGMDRD861 | BRD-K92856060 | 1 |
| iGMDRD537 | Silmitasertib | 1 |
| iGMDRD890 | CR.1.31B | 1 |
| iGMDRD21 | Fluorouracil | 1 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD1 | Nicotin-Amide | 1 |
| iGMDRD75 | Lovastatin | 1 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD866 | BRD1812 | 1 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD273 | Alvocidib | 1 |
| iGMDRD94 | Narciclasine | 1 |
| iGMDRD340 | SU 11274 | 1 |
| iGMDRD602 | Foretinib | 2 |
| iGMDRD464 | RAF265 | 1 |
| iGMDRD851 | BRD-K34222889 | 1 |
| iGMDRD226 | ML006 | 1 |
| iGMDRD848 | BRD-K28456706 | 1 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD681 | SB-743921 | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD50 | Cytarabine | 1 |
| iGMDRD569 | MOMELOTINIB | 1 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD87 | Epigallocatechin-3-monogallate | 1 |
| iGMDRD664 | Dinaciclib | 1 |
| iGMDRD244 | ML311 | 1 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD103 | SN-38 | 1 |
| iGMDRD682 | GSK4112 | 1 |
| iGMDRD439 | KW-2449 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in XPO1
CLASSFICATION
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