iGMDRD569

Canonical SMILES: C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N

InChI: InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)

InChI Key: ZVHNDZWQTBEVRY-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameMOMELOTINIB
Pubchem CID25062800
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

JAK1JAK2

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 1BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 3undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3

Drug-gene pathway enrichments

5reactome: Signal Transduction2reactome: SHC1 events in ERBB2 signaling2netpath: TNFalpha2reactome: Signaling by ERBB22reactome: MAPK family signaling cascades2wikipathways: White fat cell differentiation2reactome: Signaling by Receptor Tyrosine Kinases2reactome: Transcriptional regulation by RUNX12reactome: Disease2reactome: Generic Transcription Pathway

Drug-gene GO enrichments

6CC: nucleus5MF: protein binding5CC: nucleoplasm4BP: positive regulation of transcription by RNA polymerase II3BP: chromatin remodeling3MF: RNA polymerase II proximal promoter sequence-specific DNA binding3BP: positive regulation of transcription, DNA-templated3BP: protein export from nucleus3MF: protein tyrosine kinase activity3MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
7514 XPO1 1
6598 SMARCB1 1
2625 GATA3 1
7495 XBP1P1 1
Showing 1 to 4 of 5 rows

Gene in drug-gene network: Network Plot

Models in MOMELOTINIB

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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