SMARCB1
Summary: The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | MIM:601607 | Ensembl:ENSG00000099956 | HGNC:HGNC:11103 | PA35953 | 22q11.23|22q11 |
GO terms in SMARCB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | HDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IMP | GO:0001164 | RNA polymerase I CORE element sequence-specific DNA binding |
| MF | IPI | GO:0002039 | p53 binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IMP | GO:0003713 | transcription coactivator activity |
| MF | NAS | GO:0003713 | transcription coactivator activity |
| MF | IBA | GO:0005515 | protein binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0030957 | Tat protein binding |
| MF | HDA | GO:0031492 | nucleosomal DNA binding |
| CC | HDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0016514 | SWI/SNF complex |
| CC | IDA | GO:0016514 | SWI/SNF complex |
| CC | HDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | ISS | GO:0071564 | npBAF complex |
| CC | ISS | GO:0071565 | nBAF complex |
| BP | IEA | GO:0001188 | RNA polymerase I transcriptional preinitiation complex assembly |
| BP | IBA | GO:0006281 | DNA repair |
| BP | IBA | GO:0006337 | nucleosome disassembly |
| BP | IDA | GO:0006337 | nucleosome disassembly |
| BP | IDA | GO:0006338 | chromatin remodeling |
| BP | IMP | GO:0006338 | chromatin remodeling |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | NAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0007399 | nervous system development |
| BP | IBA | GO:0008285 | negative regulation of cell proliferation |
| BP | TAS | GO:0015074 | DNA integration |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0039692 | single stranded viral RNA replication via double stranded DNA intermediate |
| BP | HDA | GO:0043044 | ATP-dependent chromatin remodeling |
| BP | IBA | GO:0043044 | ATP-dependent chromatin remodeling |
| BP | IMP | GO:0043923 | positive regulation by host of viral transcription |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IMP | GO:0090240 | positive regulation of histone H4 acetylation |
| BP | IMP | GO:1900110 | negative regulation of histone H3-K9 dimethylation |
| BP | IMP | GO:1900113 | negative regulation of histone H3-K9 trimethylation |
| BP | IGI | GO:1901838 | positive regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| BP | IMP | GO:1901838 | positive regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| BP | IDA | GO:1902661 | positive regulation of glucose mediated signaling pathway |
| BP | IMP | GO:2000617 | positive regulation of histone H3-K9 acetylation |
| BP | IMP | GO:2000618 | regulation of histone H4-K16 acetylation |
Gene expression in normal tissue: SMARCB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SMARCB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | hswisnfpathway | chromatin remodeling by hswi/snf atp-dependent complexes |
| biocarta | pcafpathway | the information processing pathway at the ifn beta enhancer |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3214858 | RMTs methylate histone arginines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| wikipathways | WP4204 | Tumor suppressor activity of SMARCB1 |
| pid | erb_genomic_pathway | Validated nuclear estrogen receptor beta network |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD414 | MST-312 | 1 |
| iGMDRD3 | PD-173074 | 1 |
| iGMDRD886 | Compound 1541A | 5 |
| iGMDRD412 | VX-702 | 1 |
| iGMDRD917 | HDAC inhibitor | 2 |
| iGMDRD208 | Necrosulfonamide | 1 |
| iGMDRD379 | BIBR-1532 | 1 |
| iGMDRD241 | Sunitinib | 1 |
| iGMDRD867 | BRD1835 | 1 |
| iGMDRD178 | MG-132 | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD499 | PDMP | 1 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD426 | WP1130 | 1 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD404 | PD318088 | 1 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD410 | Ko-143 | 1 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD256 | NVP-231 | 1 |
| iGMDRD701 | NVP-AUY922 | 5 |
| iGMDRD761 | KHS101 | 1 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD212 | ML031 | 1 |
| iGMDRD640 | CAY10618 | 1 |
| iGMDRD451 | Serdemetan | 7 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD907 | EZH2 inhibitor | 6 |
| iGMDRD203 | STF-31 | 1 |
| iGMDRD440 | Nutlin-3A | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD375 | GW-405833 | 5 |
| iGMDRD136 | Nutlin-3 | 1 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD313 | Axitinib | 1 |
| iGMDRD744 | EPZ-6438 | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD228 | ML029 | 1 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD105 | Triptolide | 4 |
| iGMDRD197 | DBeQ | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD154 | NSC23766 | 5 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD569 | MOMELOTINIB | 1 |
| iGMDRD681 | SB-743921 | 1 |
| iGMDRD321 | Daporinad | 1 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD190 | Nilotinib | 2 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 1 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD272 | GSK-3 Inhibitor IX | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD385 | CD1530 | 1 |
| iGMDRD222 | HC-067047 | 1 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD1 | Nicotin-Amide | 1 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD781 | Sirolimus | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SMARCB1
CLASSFICATION
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