iGMDRD744


Canonical SMILES: CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5

InChI: InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)

InChI Key: NSQSAUGJQHDYNO-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameEPZ-6438
Pubchem CID66558700
DRUGBANK IDDB12887
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

2reactome: Gene expression (Transcription)2reactome: Signal Transduction2reactome: Intracellular signaling by second messengers2wikipathways: Tumor suppressor activity of SMARCB12reactome: PTEN Regulation2reactome: RNA Polymerase II Transcription2reactome: Regulation of PTEN gene transcription2reactome: Chromatin organization2reactome: Generic Transcription Pathway2reactome: PIP3 activates AKT signaling

Drug-gene GO enrichments

3CC: nucleoplasm3BP: negative regulation of gene expression, epigenetic3MF: protein binding3CC: nucleus2MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding2CC: SWI/SNF complex2MF: RNA polymerase II proximal promoter sequence-specific DNA binding2BP: nucleosome disassembly2BP: regulation of transcription by RNA polymerase II2BP: chromatin remodeling

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
6598 SMARCB1 2
2146 EZH2 4
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Models in EPZ-6438

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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