EZH2
Summary: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| enhancer of zeste 2 polycomb repressive complex 2 subunit | MIM:601573 | Ensembl:ENSG00000106462 | HGNC:HGNC:3527 | PA27939 | 7q36.1 |
GO terms in EZH2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0035098 | ESC/E(Z) complex |
| CC | IEA | GO:0045120 | pronucleus |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006306 | DNA methylation |
| BP | TAS | GO:0006325 | chromatin organization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| BP | IEA | GO:0014013 | regulation of gliogenesis |
| BP | IEA | GO:0014834 | skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration |
| BP | IEA | GO:0014898 | cardiac muscle hypertrophy in response to stress |
| BP | IMP | GO:0016571 | histone methylation |
| BP | IEA | GO:0021695 | cerebellar cortex development |
| BP | IEA | GO:0021766 | hippocampus development |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter |
| BP | IEA | GO:0035984 | cellular response to trichostatin A |
| BP | IEA | GO:0036333 | hepatocyte homeostasis |
| BP | IEA | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0042752 | regulation of circadian rhythm |
| BP | IDA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IEA | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0043547 | positive regulation of GTPase activity |
| BP | IEA | GO:0045605 | negative regulation of epidermal cell differentiation |
| BP | IDA | GO:0045814 | negative regulation of gene expression, epigenetic |
| BP | IMP | GO:0045814 | negative regulation of gene expression, epigenetic |
| BP | TAS | GO:0045814 | negative regulation of gene expression, epigenetic |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway |
| BP | IEA | GO:0048511 | rhythmic process |
| BP | IEA | GO:0051154 | negative regulation of striated muscle cell differentiation |
| BP | IEA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IEA | GO:0070314 | G1 to G0 transition |
| BP | TAS | GO:0070317 | negative regulation of G0 to G1 transition |
| BP | IDA | GO:0070734 | histone H3-K27 methylation |
| BP | IEA | GO:0071168 | protein localization to chromatin |
| BP | IDA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| BP | IEA | GO:0097421 | liver regeneration |
| BP | IEA | GO:0098532 | histone H3-K27 trimethylation |
| BP | IEA | GO:1900006 | positive regulation of dendrite development |
| BP | IEA | GO:1904772 | response to tetrachloromethane |
| BP | IEA | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle |
| MF | ISS | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0016279 | protein-lysine N-methyltransferase activity |
| MF | IDA | GO:0018024 | histone-lysine N-methyltransferase activity |
| MF | TAS | GO:0018024 | histone-lysine N-methyltransferase activity |
| MF | IDA | GO:0031490 | chromatin DNA binding |
| MF | IDA | GO:0042054 | histone methyltransferase activity |
| MF | IMP | GO:0042054 | histone methyltransferase activity |
| MF | IEA | GO:0043021 | ribonucleoprotein complex binding |
| MF | IDA | GO:0046976 | histone methyltransferase activity (H3-K27 specific) |
| MF | TAS | GO:0046976 | histone methyltransferase activity (H3-K27 specific) |
| MF | IEA | GO:0070878 | primary miRNA binding |
| MF | IDA | GO:1990841 | promoter-specific chromatin binding |
Gene expression in normal tissue: EZH2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EZH2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212300 | PRC2 methylates histones and DNA |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8953750 | Transcriptional Regulation by E2F6 |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| biocarta | prc2pathway | the prc2 complex sets long-term gene silencing through modification of histone tails |
| kegg | hsa00310 | Lysine degradation - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2023 | Cell Differentiation - Index expanded |
| wikipathways | WP2369 | Histone Modifications |
| wikipathways | WP2853 | Endoderm Differentiation |
| wikipathways | WP2916 | Interactome of polycomb repressive complex 2 (PRC2) |
| wikipathways | WP3404 | Oxidative Stress Induced Senescence |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| wikipathways | WP4204 | Tumor suppressor activity of SMARCB1 |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD504 | Obatoclax | 1 |
| iGMDRD593 | CX-5461 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD907 | EZH2 inhibitor | 2 |
| iGMDRD509 | NVP-BHG712 | 1 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD264 | Bryostatin 1 | 1 |
| iGMDRD743 | EPZ005687 | 4 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD652 | UNC0638 | 1 |
| iGMDRD678 | Tubastatin A | 1 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD745 | Tazemetostat | 2 |
| iGMDRD744 | EPZ-6438 | 4 |
| iGMDRD795 | BMN 673 | 1 |
| iGMDRD719 | IOX2 | 1 |
| iGMDRD54 | Phenformin | 1 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD749 | ZINC6718453 | 1 |
| iGMDRD752 | SCHEMBL2593705 | 3 |
| iGMDRD1002 | rTRAIL | 1 |
| iGMDRD374 | Zibotentan (ZD4054) | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD461 | VX-11e | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EZH2
CLASSFICATION
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