iGMDRD228

Canonical SMILES: CC1=CC2=C(C=C1C)N(C(=N2)NCCCO)CC(=O)C3=CC(=C(C(=C3)C(C)(C)C)O)C(C)(C)C

InChI: InChI=1S/C28H39N3O3/c1-17-12-22-23(13-18(17)2)31(26(30-22)29-10-9-11-32)16-24(33)19-14-20(27(3,4)5)25(34)21(15-19)28(6,7)8/h12-15,32,34H,9-11,16H2,1-8H3,(H,29,30)

InChI Key: CYCGGKILBWERDJ-UHFFFAOYSA-N

Loading, please wait...
Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameML029
Pubchem CID2858520
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 2undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3

Drug-gene pathway enrichments

2wikipathways: ESC Pluripotency Pathways2reactome: Signal Transduction2reactome: RNA Polymerase II Transcription2wikipathways: Protein alkylation leading to liver fibrosis2reactome: Gene expression (Transcription)2reactome: Generic Transcription Pathway1kegg: Hippo signaling pathway - Homo sapiens (human)1kegg: Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)1kegg: Transcriptional misregulation in cancer - Homo sapiens (human)1wikipathways: Bone Morphogenic Protein (BMP) Signalling and Regulation

Drug-gene GO enrichments

7CC: nucleus4BP: BMP signaling pathway4CC: cytoplasm4MF: protein binding3BP: positive regulation of transcription by RNA polymerase II3MF: platelet-derived growth factor binding3BP: positive regulation of ERK1 and ERK2 cascade3CC: nucleoplasm3MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding3MF: platelet-derived growth factor beta-receptor activity

Drug-Gene: Aster Plot


Loading, please wait...
Gene ID
Gene Name
Model Num.
6598 SMARCB1 1
5159 PDGFRB 1
4086 SMAD1 1
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

Models in ML029

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(TRANSGLUTAMINASE) protein MCLP LUNG undefined ML029 sensitivity in vitro
EXP(SNF5) protein MCLP LUNG undefined ML029 resistance in vitro
EXP(PAXILLIN) protein MCLP undefined PANCAN ML029 sensitivity in vitro
EXP(SMAD1) protein MCLP undefined PANCAN ML029 resistance in vitro
EXP(PDGFRB) protein MCLP undefined PANCAN ML029 resistance in vitro
Showing 1 to 5 of 5 rows

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.