SMAD1
Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SMAD family member 1 | MIM:601595 | Ensembl:ENSG00000170365 | HGNC:HGNC:6767 | PA30524 | 4q31.21 |
Gene Categories:
TRANSCRIPTION FACTOR COMPLEXGO terms in SMAD1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | NAS | GO:0005622 | intracellular |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | NAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005637 | nuclear inner membrane |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | NAS | GO:0071141 | SMAD protein complex |
| BP | IEA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0001657 | ureteric bud development |
| BP | IEA | GO:0001710 | mesodermal cell fate commitment |
| BP | IEA | GO:0002051 | osteoblast fate commitment |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | NAS | GO:0007165 | signal transduction |
| BP | NAS | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IDA | GO:0007183 | SMAD protein complex assembly |
| BP | IEA | GO:0007276 | gamete generation |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | ISS | GO:0009880 | embryonic pattern specification |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IDA | GO:0030509 | BMP signaling pathway |
| BP | IMP | GO:0030509 | BMP signaling pathway |
| BP | ISS | GO:0030509 | BMP signaling pathway |
| BP | TAS | GO:0030509 | BMP signaling pathway |
| BP | IEA | GO:0030901 | midbrain development |
| BP | IEA | GO:0030902 | hindbrain development |
| BP | TAS | GO:0031053 | primary miRNA processing |
| BP | IEA | GO:0042592 | homeostatic process |
| BP | IEA | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | IC | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0051216 | cartilage development |
| BP | IEA | GO:0060038 | cardiac muscle cell proliferation |
| BP | IEA | GO:0060348 | bone development |
| BP | ISS | GO:0060395 | SMAD protein signal transduction |
| BP | NAS | GO:0060395 | SMAD protein signal transduction |
| BP | IEA | GO:0061036 | positive regulation of cartilage development |
| BP | ISS | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
| BP | IEA | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IMP | GO:1903672 | positive regulation of sprouting angiogenesis |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0017151 | DEAD/H-box RNA helicase binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | TAS | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0070410 | co-SMAD binding |
| MF | IPI | GO:0070411 | I-SMAD binding |
| MF | IPI | GO:0070878 | primary miRNA binding |
Gene expression in normal tissue: SMAD1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SMAD1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | alk1pathway | ALK1 signaling events |
| pid | alk2pathway | ALK2 signaling events |
| pid | bmppathway | BMP receptor signaling |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| netpath | Pathway_Wnt | Wnt |
| humancyc | PWY66-11 | BMP Signalling Pathway |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| wikipathways | WP1425 | Bone Morphogenic Protein (BMP) Signalling and Regulation |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP1591 | Heart Development |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP2895 | Differentiation of white and brown adipocyte |
| wikipathways | WP3876 | BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation |
| wikipathways | WP3927 | BMP Signaling Pathway in Eyelid Development |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-201451 | Signaling by BMP |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8941326 | RUNX2 regulates bone development |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| biocarta | alkpathway | alk in cardiac myocytes |
| biocarta | ctcfpathway | ctcf: first multivalent nuclear factor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD852 | BRD-K35604418 | 1 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD134 | Sorafenib | 1 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD734 | AZ3146 | 1 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD145 | Omacetaxine mepesuccinate | 1 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD444 | Tivantinib | 1 |
| iGMDRD304 | CH 55 | 1 |
| iGMDRD533 | HSCI1_000270 | 1 |
| iGMDRD229 | B02 | 1 |
| iGMDRD857 | BRD-K70511574 | 1 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD723 | MI-2 | 1 |
| iGMDRD66 | Doxorubicin | 1 |
| iGMDRD78 | Topotecan | 1 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD591 | PF-3758309 | 1 |
| iGMDRD348 | BMS-345541 | 1 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD157 | Ouabain | 1 |
| iGMDRD56 | Azacitidine | 1 |
| iGMDRD504 | Obatoclax | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD379 | BIBR-1532 | 1 |
| iGMDRD865 | BRD-M00053801 | 1 |
| iGMDRD646 | PHA-793887 | 1 |
| iGMDRD477 | AT13387 | 1 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD153 | Bardoxolone methyl | 1 |
| iGMDRD774 | ETP-46464 | 1 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD798 | Ceranib-2 | 1 |
| iGMDRD256 | NVP-231 | 1 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD178 | MG-132 | 1 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD843 | BRD-A86708339 | 1 |
| iGMDRD750 | TRIAZOLOTHIADIAZINE | 1 |
| iGMDRD435 | BI-2536 | 1 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD44 | Temozolomide | 1 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD649 | R428 | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD851 | BRD-K34222889 | 1 |
| iGMDRD1038 | X3.Cl.AHPC | 1 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD641 | SCH 79797 | 1 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD94 | Narciclasine | 1 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD273 | Alvocidib | 1 |
| iGMDRD535 | SRT-1720 | 1 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD238 | Tandutinib | 1 |
| iGMDRD1 | Nicotin-Amide | 1 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD21 | Fluorouracil | 1 |
| iGMDRD687 | I-BET151 | 1 |
| iGMDRD439 | KW-2449 | 1 |
| iGMDRD156 | HLI-373 | 1 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD228 | ML029 | 1 |
| iGMDRD265 | Dacarbazine | 1 |
| iGMDRD16 | CICLOPIROX | 1 |
| iGMDRD244 | ML311 | 1 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD771 | PF 4800567 Hydrochloride | 1 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD664 | Dinaciclib | 1 |
| iGMDRD508 | KU0063794 | 1 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD445 | Barasertib | 1 |
| iGMDRD526 | KX2-391 | 1 |
| iGMDRD209 | BRD6340 | 1 |
| iGMDRD370 | TPCA-1 | 1 |
| iGMDRD392 | Masitinib | 1 |
| iGMDRD50 | Cytarabine | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD681 | SB-743921 | 1 |
| iGMDRD845 | BRD-K09344309 | 1 |
| iGMDRD423 | AT 7867 | 1 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD49 | Mitomycin | 1 |
| iGMDRD548 | Marinopyrrole A | 1 |
| iGMDRD540 | Alisertib | 1 |
| iGMDRD541 | SNX-2112 (PF-04928473) | 1 |
| iGMDRD176 | Decitabine | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SMAD1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.