iGMDRD771

Canonical SMILES: C1COCCC1N2C3=C(C(=N2)COC4=CC(=CC=C4)Cl)C(=NC=N3)N.Cl

InChI: InChI=1S/C17H18ClN5O2.ClH/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12;/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21);1H

InChI Key: QZXZQMUZEHTFHD-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NamePF 4800567 Hydrochloride
Pubchem CID71751600
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

LIVEtissue: LIVE cancer: LIVER model num: 0LIVERtissue: LIVER cancer: undefined model num: 2undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Drug-gene pathway enrichments

1reactome: Signal Transduction1reactome: Signaling by BMP1reactome: Generic Transcription Pathway1reactome: Metabolism of proteins1wikipathways: TGF-beta Receptor Signaling1wikipathways: Protein alkylation leading to liver fibrosis1wikipathways: BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation1wikipathways: BMP Signaling Pathway in Eyelid Development1wikipathways: ESC Pluripotency Pathways1reactome: Deubiquitination

Drug-gene GO enrichments

5CC: nucleus4BP: BMP signaling pathway3MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding3CC: cytoplasm2BP: positive regulation of transcription by RNA polymerase II2BP: regulation of keratinocyte differentiation2MF: protein binding2MF: protein kinase binding2BP: negative regulation of epidermal growth factor-activated receptor activity2CC: cytosol

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
4086 SMAD1 1
54206 ERRFI1 1
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

SMAD1SMAD1ERRFI1ERRFI1PF 4800567 HydrochloridePF 4800567 Hydrochloride

Models in PF 4800567 Hydrochloride

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(MIG6) protein MCLP LIVER undefined PF.4800567.hydrochloride sensitivity in vitro
EXP(NFKBP65_pS536) protein MCLP LIVER undefined PF.4800567.hydrochloride sensitivity in vitro
EXP(P38_pT180Y182) protein MCLP undefined PANCAN PF.4800567.hydrochloride sensitivity in vitro
EXP(SMAD1) protein MCLP undefined PANCAN PF.4800567.hydrochloride sensitivity in vitro
Showing 1 to 4 of 4 rows

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