ERRFI1
Summary: ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ERBB receptor feedback inhibitor 1 | MIM:608069 | Ensembl:ENSG00000116285 | HGNC:HGNC:18185 | PA142671904 | 1p36.23 |
GO terms in ERRFI1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005634 | nucleus |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | ISS | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| BP | IDA | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity |
| BP | ISS | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity |
| BP | IDA | GO:0031953 | negative regulation of protein autophosphorylation |
| BP | IEA | GO:0032691 | negative regulation of interleukin-1 beta production |
| BP | IEA | GO:0032869 | cellular response to insulin stimulus |
| BP | IEA | GO:0032966 | negative regulation of collagen biosynthetic process |
| BP | IEA | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| BP | IBA | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| BP | IEA | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | ISS | GO:0043589 | skin morphogenesis |
| BP | IBA | GO:0045616 | regulation of keratinocyte differentiation |
| BP | ISS | GO:0045616 | regulation of keratinocyte differentiation |
| BP | ISS | GO:0048286 | lung alveolus development |
| BP | ISS | GO:0060426 | lung vasculature development |
| BP | ISS | GO:0060428 | lung epithelium development |
| BP | IEA | GO:0061469 | regulation of type B pancreatic cell proliferation |
| BP | IEA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IEA | GO:0071474 | cellular hyperosmotic response |
| BP | IEA | GO:0071549 | cellular response to dexamethasone stimulus |
| BP | IEA | GO:1903243 | negative regulation of cardiac muscle hypertrophy in response to stress |
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0017124 | SH3 domain binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0031267 | small GTPase binding |
Gene expression in normal tissue: ERRFI1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ERRFI1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD519 | GDC-0941 | 1 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD317 | CCT 018159 | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD97 | Bexarotene | 1 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD831 | BCL.LZH.4 | 1 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD354 | Midostaurin | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD771 | PF 4800567 Hydrochloride | 1 |
| iGMDRD291 | AC1NS4S0 | 1 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD173 | Epothilone B | 1 |
| iGMDRD293 | Bleomycin | 1 |
| iGMDRD700 | AUY922 | 1 |
| iGMDRD573 | GSK-1904529A | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD504 | Obatoclax | 1 |
| iGMDRD396 | AS601245 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ERRFI1
CLASSFICATION
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