iGMDRD573

Canonical SMILES: CCC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)S(=O)(=O)C)OC)NC4=NC=CC(=N4)C5=C(N=C6N5C=CC=C6)C7=CC(=C(C=C7)OC)C(=O)NC8=C(C=CC=C8F)F

InChI: InChI=1S/C44H47F2N9O5S/c1-5-28-26-35(38(60-3)27-36(28)53-19-15-30(16-20-53)52-21-23-54(24-22-52)61(4,57)58)49-44-47-17-14-34(48-44)42-40(50-39-11-6-7-18-55(39)42)29-12-13-37(59-2)31(25-29)43(56)51-41-32(45)9-8-10-33(41)46/h6-14,17-18,25-27,30H,5,15-16,19-24H2,1-4H3,(H,51,56)(H,47,48,49)

InChI Key: MOSKATHMXWSZTQ-UHFFFAOYSA-N

Loading, please wait...
Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameGSK-1904529A
CHEMBLCHEMBL466397
Pubchem CID25124800
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

IGF1RIR

Drug Pathways:

IGFR signaling

Drug-model tissue-cancer distribution: Bubble Plot

BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 22BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1STOMACtissue: STOMAC cancer: STOMACH model num: 0STOMACHtissue: STOMACH cancer: Esophageal Adenocarcinoma (ESCA) model num: 1STOMACHtissue: STOMACH cancer: Stomach Adenocarcinoma (STAD) model num: 1HEAD_NECtissue: HEAD_NEC cancer: HEAD_NECK model num: 0HEAD_NECKtissue: HEAD_NECK cancer: Head and Neck Squamous Cell Carcinoma (HNSC) model num: 1LIVEtissue: LIVE cancer: LIVER model num: 0LIVERtissue: LIVER cancer: Hepatocellular Carcinoma (HCC) model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Adenocarcinoma (LUAD) model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 1

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Loading, please wait...
Gene ID
Gene Name
Model Num.
2956 MSH6 1
8289 ARID1A 1
9757 KMT2B 1
55294 FBXW7 1
Showing 1 to 4 of 25 rows rows per page

Gene in drug-gene network: Network Plot

KU0060648KU0060648PD0325901PD0325901WWTR1WWTR1tipifarnib-P2tipifarnib-P2GefitnibGefitnibcetuximabcetuximabGW-405833GW-405833BIX01294BIX01294NSC95397NSC95397DC-45-A2DC-45-A2DacomitinibDacomitinibAfatnibAfatnibirreversible EGFR TKIsirreversible EGFR TKIsErlotinibErlotinibPanitumumabPanitumumabEGFR TKIsEGFR TKIsOsimertinibOsimertinibHSP90 inhibitorsHSP90 inhibitorspevonedistatpevonedistatMEK inhibitors (alone or in combination)MEK inhibitors (alone or in combination)nutlin 3nutlin 3EGFREGFRkinetin ribosidekinetin ribosideitraconazoleitraconazoleBRD6368BRD6368leucascandrolide Aleucascandrolide AFedratinibFedratinibGMX1778GMX1778Tyrphostin AG 1478Tyrphostin AG 1478Nsc 632839Nsc 632839teniposideteniposideBRD7137BRD7137GemcitabineGemcitabineARID1AARID1APX 12PX 12quinoclaminequinoclamineCIL55ACIL55AisoevodiamineisoevodiamineparbendazoleparbendazoleML162ML162nakiterpiosinnakiterpiosinLY 2183240LY 2183240NPC26NPC26gossypolgossypolML214ML214piperlonguminepiperlongumineFqi1Fqi1TGFB1TGFB1IdarubicinIdarubicinBMS-536924BMS-536924NSC141540NSC141540VX-680VX-680zebularinezebularineFQI-2FQI-2MSH6MSH6DasatnibDasatnibCHIR-99021CHIR-99021austocystin.Daustocystin.DRO-3306RO-3306SERPINE1SERPINE1RITARITACDK2/4 inhibitorsCDK2/4 inhibitorsVNLG/124VNLG/124SCHEMBL2608041SCHEMBL2608041SirolimusSirolimusCDKN1BCDKN1BPertuzumabPertuzumabNeratinibNeratinibcytochalasin.Bcytochalasin.Blapatinib in HER2-amplifiedlapatinib in HER2-amplifiedEverolimusEverolimusABT737ABT737ERBB2 TKIsERBB2 TKIschaetocinchaetocinchemotherapychemotherapy179324-69-7179324-69-7Vorinostat (SAHA)Vorinostat (SAHA)PAC-1PAC-1Ado-trastuzumab emtansineAdo-trastuzumab emtansinetrastuzumab alonetrastuzumab aloneERBB2ERBB2selumetinib in BRAF mutant tumorsselumetinib in BRAF mutant tumorsBicalutamideBicalutamideIdelalisibIdelalisibZSTK 474ZSTK 474X17AAGX17AAGRG108RG108ABT-263ABT-263Bryostatin.1Bryostatin.1PD-0325901PD-0325901FOSL1FOSL1BMS-754807BMS-754807navitoclaxnavitoclaxSYK inhibitorsSYK inhibitorsSYKSYKMST-312MST-312neopeltolideneopeltolideFK 866FK 866PD-0332991PD-0332991GW-843682XGW-843682XSR-II-138ASR-II-138ANSC23766NSC23766MDM2/MDMX inhibitorsMDM2/MDMX inhibitors4-methylfasudil4-methylfasudilRB1RB1PIK-75PIK-75AZD-1775AZD-1775ceruleninceruleninAACOCF3AACOCF3(-)-gallocatechin-3-O-gallate(-)-gallocatechin-3-O-gallateKDRKDRciclosporinciclosporinML 210ML 210lovastatin acidlovastatin acidPDMPPDMP(1S,3R)-RSL3(1S,3R)-RSL3indisulamindisulamFBXW7FBXW7Compound.1541ACompound.1541AMerck60Merck60avrainvillamideavrainvillamideAM-580AM-580oligomycin.Aoligomycin.APARP1PARP1salermidesalermideNutlin-3aNutlin-3aMytomycin CMytomycin CY-39983Y-39983Liposomal DoxorubicinLiposomal DoxorubicinCis-PlatinCis-PlatinTP53TP53cimetidinecimetidineX681640X681640I-BET151I-BET151CAY-10594CAY-10594docetaxel in KRAS mutantdocetaxel in KRAS mutantnarciclasinenarciclasineNSC74859NSC74859canertinibcanertinibJQ1 CompoundJQ1 CompoundGSK 525762AGSK 525762AEpigallocatechin-3-monogallateEpigallocatechin-3-monogallateBosutinibBosutinibKU-55933KU-55933NVP-BSK805NVP-BSK805BRD-K29086754BRD-K29086754ML320ML320IFI27IFI27brefeldin.Abrefeldin.AParthenolideParthenolideCIL56CIL56tanespimycintanespimycinall trans Retinoic Acidall trans Retinoic AcidLY317615LY317615STF62247STF62247WZ3105WZ3105GW2580GW2580RAD21RAD21SCHEMBL618594SCHEMBL618594CX-5461CX-5461KMT2BKMT2BMET inhibitorsMET inhibitorsPF-2341066PF-2341066EGFR inhibitor 1st genEGFR inhibitor 1st genCapmatinibCapmatinibVemurafenibVemurafenibXL-184XL-184RNMTRNMTPI-103PI-103SB225002SB225002bistramide Abistramide APARP inhibitorsPARP inhibitorsCD437CD437MAGI1MAGI1BX-795BX-795MK-2206MK-2206FOXO3FOXO3MEK inhibitorsMEK inhibitorsLY3023414LY3023414GSK2636771GSK2636771BRD63610BRD63610VER 155008VER 155008mTOR inhibitorsmTOR inhibitorsOlaparibOlaparibPI3K pathway inhibitorsPI3K pathway inhibitorsAZD8186AZD8186GSK690693GSK690693PTENPTENCompound 44Compound 44CobimetinibCobimetinibSorafenibSorafenibBRAF inhibitorsBRAF inhibitorspan-RAF inhibitorspan-RAF inhibitorsPLX-4720PLX-4720DabrafenibDabrafenibRefametinibRefametinibTrametinibTrametinibBRAFBRAFERRFI1ERRFI1CAY10618CAY10618tivozanibtivozanibHSCI1_000270HSCI1_000270NVP-231NVP-231SB-743921SB-743921daporinaddaporinadDPP4DPP4GSK-1904529AGSK-1904529A

Models in GSK-1904529A

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(MSH6) protein MCLP BLOOD undefined GSK.1904529A sensitivity in vitro
EXP(BCLXL) protein MCLP undefined PANCAN GSK.1904529A resistance in vitro
EXP(CAVEOLIN1) protein MCLP undefined PANCAN GSK.1904529A resistance in vitro
EXP(EGFR) protein MCLP undefined PANCAN GSK.1904529A resistance in vitro
EXP(FOXO3A) protein MCLP undefined PANCAN GSK.1904529A resistance in vitro
EXP(MIG6) protein MCLP undefined PANCAN GSK.1904529A resistance in vitro
EXP(PAI1) protein MCLP undefined PANCAN GSK.1904529A resistance in vitro
EXP(PAXILLIN) protein MCLP undefined PANCAN GSK.1904529A resistance in vitro
EXP(SYK) protein MCLP undefined PANCAN GSK.1904529A sensitivity in vitro
EXP(VEGFR2) protein MCLP undefined PANCAN GSK.1904529A resistance in vitro
Showing 1 to 10 of 32 rows rows per page

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.