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FOSL1

Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameFOS like 1, AP-1 transcription factor subunit OMIM IDMIM:136515 Ensembl IDEnsembl:ENSG00000175592 HGNC IDHGNC:HGNC:13718 PHARMGKB IDPA28214 Map Location11q13.1

Gene Categories:

DRUG RESISTANCE TUMOR SUPPRESSOR

GO terms in FOSL1

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0001701	in utero embryonic development
BP	IBA	GO:0006357	regulation of transcription by RNA polymerase II
BP	TAS	GO:0006357	regulation of transcription by RNA polymerase II
BP	TAS	GO:0006366	transcription by RNA polymerase II
BP	TAS	GO:0006935	chemotaxis
BP	TAS	GO:0006968	cellular defense response

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Gene expression in normal tissue: FOSL1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOSL1

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Database	Pathway ID	Pathway Des.
biocarta	ranklpathway	bone remodeling
pid	ap1_pathway	AP-1 transcription factor network
pid	cd8tcrdownstreampathway	Downstream signaling in naïve CD8+ T cells
pid	fra_pathway	Validated transcriptional targets of AP1 family members Fra1 and Fra2
pid	myc_activpathway	Validated targets of C-MYC transcriptional activation
pid	nfat_tfpathway	Calcineurin-regulated NFAT-dependent transcription in lymphocytes

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD12	Bicalutamide	1
iGMDRD199	RG108	1
iGMDRD463	ZSTK 474	1
iGMDRD1036	X17AAG	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOSL1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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