iGMDRD455
Canonical SMILES: CCC(C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5
InChI: InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1
InChI Key: IFSDAJWBUCMOAH-HNNXBMFYSA-N
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Standard Name | CHEMBL | Pubchem CID | DRUGBANK ID | Drug Status | Drug Type |
|---|---|---|---|---|---|
Standard NameIdelalisib CHEMBLCHEMBL2216870 Pubchem CID11625800 DRUGBANK IDDB09054 Drug StatusAlone Drug TypeSmall Molecule | |||||
Drug Class:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 SubstratesClass Ia Phosphatidylinositol 3-Kinase, antagonists & inhibitorsCombined Inhibitors of CYP3A4 and P-glycoproteinCombined Inhibitors of CYP3A4 and P-glycoprotein (Strong)Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A Inhibitors (strong)Cytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (strong)Cytochrome P-450 Enzyme InducersCytochrome P-450 Enzyme InhibitorsEnzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 2-RingImmunosuppressive AgentsKinase InhibitorP-glycoprotein/ABCB1 InhibitorsP-glycoprotein/ABCB1 SubstratesQuinazolinesDrug Targets:
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (P110?)PI3KdeltaDrug Pathways:
PI3K/MTOR signalingDrug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
Gene in drug-gene network: Network Plot
Models in Idelalisib
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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