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iGMDRD455

Canonical SMILES: CCC(C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

InChI: InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1

InChI Key: IFSDAJWBUCMOAH-HNNXBMFYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Idelalisib	CHEMBL2216870	11625800	DB09054	Alone	Small Molecule

Drug Class:

Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Substrates Class Ia Phosphatidylinositol 3-Kinase, antagonists & inhibitors Combined Inhibitors of CYP3A4 and P-glycoprotein Combined Inhibitors of CYP3A4 and P-glycoprotein (Strong)Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Inhibitors (strong)Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong)Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 2-Ring Immunosuppressive Agents Kinase Inhibitor P-glycoprotein/ABCB1 Inhibitors P-glycoprotein/ABCB1 Substrates Quinazolines

Drug Targets:

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (P110?)PI3Kdelta

Drug Pathways:

PI3K/MTOR signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
1387	CREBBP	1
7157	TP53	1
8061	FOSL1	1
5290	PIK3CA	1
4609	MYC	1
5926	ARID4A	1
6146	RPL22	1
4893	NRAS	2

Gene in drug-gene network: Network Plot

Models in Idelalisib

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.