CREBBP
Summary: This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CREB binding protein | MIM:600140 | Ensembl:ENSG00000005339 | HGNC:HGNC:2348 | PA26866 | 16p13.3 |
GO terms in CREBBP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0001666 | response to hypoxia |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IDA | GO:0006473 | protein acetylation |
| BP | TAS | GO:0006473 | protein acetylation |
| BP | NAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007219 | Notch signaling pathway |
| BP | TAS | GO:0007221 | positive regulation of transcription of Notch receptor target |
| BP | TAS | GO:0008589 | regulation of smoothened signaling pathway |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0016573 | histone acetylation |
| BP | IDA | GO:0018076 | N-terminal peptidyl-lysine acetylation |
| BP | TAS | GO:0019216 | regulation of lipid metabolic process |
| BP | IMP | GO:0031648 | protein destabilization |
| BP | TAS | GO:0032481 | positive regulation of type I interferon production |
| BP | IDA | GO:0034644 | cellular response to UV |
| BP | NAS | GO:0042592 | homeostatic process |
| BP | TAS | GO:0042733 | embryonic digit morphogenesis |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | TAS | GO:0045637 | regulation of myeloid cell differentiation |
| BP | TAS | GO:0045747 | positive regulation of Notch signaling pathway |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | TAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048511 | rhythmic process |
| BP | TAS | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| BP | TAS | GO:0065003 | protein-containing complex assembly |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| BP | TAS | GO:1904837 | beta-catenin-TCF complex assembly |
| CC | IEA | GO:0000123 | histone acetyltransferase complex |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IC | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0016604 | nuclear body |
| MF | IDA | GO:0000987 | proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0001085 | RNA polymerase II transcription factor binding |
| MF | TAS | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | IDA | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding |
| MF | IPI | GO:0002039 | p53 binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003684 | damaged DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0003713 | transcription coactivator activity |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0004402 | histone acetyltransferase activity |
| MF | TAS | GO:0004402 | histone acetyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | EXP | GO:0016407 | acetyltransferase activity |
| MF | IDA | GO:0016407 | acetyltransferase activity |
| MF | TAS | GO:0034212 | peptide N-acetyltransferase activity |
| MF | IDA | GO:0043426 | MRF binding |
Gene expression in normal tissue: CREBBP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CREBBP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| wikipathways | WP3657 | Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3981 | miRNA regulation of prostate cancer signaling pathways |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP4241 | Type 2 papillary renal cell carcinoma |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | e2f_pathway | E2F transcription factor network |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | foxopathway | FoxO family signaling |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hdac_classiii_pathway | Signaling events mediated by HDAC Class III |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | hif2pathway | HIF-2-alpha transcription factor network |
| pid | hnf3apathway | FOXA1 transcription factor network |
| pid | ifngpathway | IFN-gamma pathway |
| pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | p53regulationpathway | p53 pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pharmgkb | PA2027 | Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| biocarta | carm1pathway | transcription regulation by methyltransferase of carm1 |
| biocarta | carmerpathway | carm1 and regulation of the estrogen receptor |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | huntingtonpathway | inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors |
| biocarta | il7pathway | il-7 signal transduction |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
| biocarta | pcafpathway | the information processing pathway at the ifn beta enhancer |
| biocarta | pelp1pathway | pelp1 modulation of estrogen receptor activity |
| biocarta | pitx2pathway | multi-step regulation of transcription by pitx2 |
| biocarta | pmlpathway | regulation of transcriptional activity by pml |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | relapathway | acetylation and deacetylation of rela in nucleus |
| biocarta | tgfbpathway | tgf beta signaling pathway |
| biocarta | wntpathway | wnt signaling pathway |
| reactome | R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor |
| reactome | R-HSA-1234174 | Regulation of Hypoxia-inducible Factor (HIF) by oxygen |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1368082 | RORA activates gene expression |
| reactome | R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian gene expression |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-186712 | Regulation of beta-cell development |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis |
| reactome | R-HSA-2262749 | Cellular response to hypoxia |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production |
| reactome | R-HSA-3214847 | HATs acetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-3371568 | Attenuation phase |
| reactome | R-HSA-3371571 | HSF1-dependent transactivation |
| reactome | R-HSA-350054 | Notch-HLH transcription pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5621575 | CD209 (DC-SIGN) signaling |
| reactome | R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| reactome | R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid cells |
| reactome | R-HSA-8941856 | RUNX3 regulates NOTCH signaling |
| reactome | R-HSA-8941856 | RUNX3 regulates NOTCH signaling |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| reactome | R-HSA-918233 | TRAF3-dependent IRF activation pathway |
| reactome | R-HSA-933541 | TRAF6 mediated IRF7 activation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD599 | Salermide | 1 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD380 | Pifithrin-alpha | 3 |
| iGMDRD480 | KU0060648 | 1 |
| iGMDRD736 | UNC1215 | 1 |
| iGMDRD138 | PX 12 | 8 |
| iGMDRD802 | 4-methylfasudil | 4 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD127 | Seliciclib | 1 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD692 | SB590885 | 1 |
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD268 | Cerulenin | 5 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD630 | ML203 | 3 |
| iGMDRD84 | Lovastatin acid | 4 |
| iGMDRD307 | Manumycin A | 8 |
| iGMDRD148 | Pifithrin-mu | 9 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD604 | 4449-51-8 | 1 |
| iGMDRD85 | Ursolic acid | 5 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD1016 | THZ-2-49 | 1 |
| iGMDRD785 | XMD15-27 | 1 |
| iGMDRD88 | AICA ribonucleotide | 1 |
| iGMDRD733 | SGC0946 | 1 |
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD3 | PD-173074 | 1 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD556 | Quizartinib | 1 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD433 | Lexibulin | 4 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD889 | Compound 7d-cis | 8 |
| iGMDRD476 | WH-4-023 | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD403 | BAY 61-3606 | 1 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD1032 | VNLG/124 | 1 |
| iGMDRD247 | Blebbistatin | 3 |
| iGMDRD568 | SCHEMBL15005512 | 1 |
| iGMDRD260 | FQI-2 | 4 |
| iGMDRD187 | BRD9876 | 5 |
| iGMDRD730 | Kahalalide F | 1 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD719 | IOX2 | 1 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD775 | NCGC00346967-01 | 1 |
| iGMDRD1018 | TL-1-85 | 1 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD1002 | rTRAIL | 1 |
| iGMDRD672 | Alectinib | 1 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD455 | Idelalisib | 1 |
| iGMDRD221 | Tamoxifen | 6 |
| iGMDRD213 | SMR000068650 | 6 |
| iGMDRD77 | Itraconazole | 4 |
| iGMDRD871 | BRD6368 | 10 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD147 | Prima-1 | 6 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD54 | Phenformin | 1 |
| iGMDRD1008 | SR-II-138A | 6 |
| iGMDRD772 | BRD4770 | 11 |
| iGMDRD239 | Dasatinib | 1 |
| iGMDRD587 | CHEMBL585951 | 1 |
| iGMDRD632 | CP466722 | 2 |
| iGMDRD201 | SKI II | 5 |
| iGMDRD696 | NG25 | 1 |
| iGMDRD193 | Fqi1 | 7 |
| iGMDRD673 | LSM-1215 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD759 | PFI-1 | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD332 | A-770041 | 1 |
| iGMDRD312 | Pelitinib | 1 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD690 | PRIMA-1MET | 9 |
| iGMDRD60 | Quinoclamine | 10 |
| iGMDRD607 | Ubistatin B | 5 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD292 | NSC87877 | 1 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD499 | PDMP | 4 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD503 | CMK | 1 |
| iGMDRD172 | T091317 | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD82 | Quiflapon | 10 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD443 | Linifanib | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD135 | Lenalidomide | 1 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD474 | Avrainvillamide | 6 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 4 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 6 |
| iGMDRD224 | Necrostatin-1 | 3 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD64 | Parbendazole | 9 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD532 | Olaparib | 4 |
| iGMDRD523 | Cyanoquinoline, 11 | 4 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD251 | ML162 | 5 |
| iGMDRD289 | Parthenolide | 9 |
| iGMDRD667 | BIX02189 | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD329 | Merck60 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CREBBP
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.