CREBBP


Summary: This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CREB binding proteinMIM:600140Ensembl:ENSG00000005339HGNC:HGNC:2348PA2686616p13.3

GO terms in CREBBP


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0001666response to hypoxia
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPIDAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIDAGO:0006473protein acetylation
BPTASGO:0006473protein acetylation
BPNASGO:0007165signal transduction
BPTASGO:0007219Notch signaling pathway
BPTASGO:0007221positive regulation of transcription of Notch receptor target
BPTASGO:0008589regulation of smoothened signaling pathway
BPIEAGO:0016032viral process
BPIDAGO:0016573histone acetylation
BPIDAGO:0018076N-terminal peptidyl-lysine acetylation
BPTASGO:0019216regulation of lipid metabolic process
BPIMPGO:0031648protein destabilization
BPTASGO:0032481positive regulation of type I interferon production
BPIDAGO:0034644cellular response to UV
BPNASGO:0042592homeostatic process
BPTASGO:0042733embryonic digit morphogenesis
BPTASGO:0042981regulation of apoptotic process
BPTASGO:0045637regulation of myeloid cell differentiation
BPTASGO:0045747positive regulation of Notch signaling pathway
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPTASGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048511rhythmic process
BPTASGO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia
BPTASGO:0065003protein-containing complex assembly
BPTASGO:1900034regulation of cellular response to heat
BPTASGO:1904837beta-catenin-TCF complex assembly
CCIEAGO:0000123histone acetyltransferase complex
CCIDAGO:0000790nuclear chromatin
CCICGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0016604nuclear body
MFIDAGO:0000987proximal promoter sequence-specific DNA binding
MFIDAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIPIGO:0001085RNA polymerase II transcription factor binding
MFTASGO:0001102RNA polymerase II activating transcription factor binding
MFIDAGO:0001191transcriptional repressor activity, RNA polymerase II transcription factor binding
MFIPIGO:0002039p53 binding
MFIDAGO:0003682chromatin binding
MFIDAGO:0003684damaged DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003713transcription coactivator activity
MFIPIGO:0003713transcription coactivator activity
MFTASGO:0003713transcription coactivator activity
MFIDAGO:0004402histone acetyltransferase activity
MFTASGO:0004402histone acetyltransferase activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIEAGO:0008270zinc ion binding
MFEXPGO:0016407acetyltransferase activity
MFIDAGO:0016407acetyltransferase activity
MFTASGO:0034212peptide N-acetyltransferase activity
MFIDAGO:0043426MRF binding

Gene expression in normal tissue: CREBBP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CREBBP


DatabasePathway IDPathway Des.
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1539Angiogenesis
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP268Notch Signaling Pathway
wikipathwaysWP3414Initiation of transcription and translation elongation at the HIV-1 LTR
wikipathwaysWP364IL-6 signaling pathway
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
wikipathwaysWP3657Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host
wikipathwaysWP4241Type 2 papillary renal cell carcinoma
wikipathwaysWP4242Notch Signaling Pathway
wikipathwaysWP560TGF-beta Receptor Signaling
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
pidar_tf_pathwayRegulation of Androgen receptor activity
pidcmyb_pathwayC-MYB transcription factor network
pide2f_pathwayE2F transcription factor network
pidfoxm1pathwayFOXM1 transcription factor network
pidfoxopathwayFoxO family signaling
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidhdac_classiii_pathwaySignaling events mediated by HDAC Class III
pidhedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
pidhes_heypathwayNotch-mediated HES/HEY network
pidhif1_tfpathwayHIF-1-alpha transcription factor network
pidhif2pathwayHIF-2-alpha transcription factor network
pidhnf3apathwayFOXA1 transcription factor network
pidifngpathwayIFN-gamma pathway
pidil12_stat4pathwayIL12 signaling mediated by STAT4
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidp53downstreampathwayDirect p53 effectors
pidp53regulationpathwayp53 pathway
pidps1pathwayPresenilin action in Notch and Wnt signaling
pidrb_1pathwayRegulation of retinoblastoma protein
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidretinoic_acid_pathwayRetinoic acid receptors-mediated signaling
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
pidtcptp_pathwaySignaling events mediated by TCPTP
pharmgkbPA2027Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
netpathPathway_IL4IL4
netpathPathway_IL6IL6
netpathPathway_ProlactinProlactin
netpathPathway_TCRTCR
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
netpathPathway_TNFalphaTNFalpha
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04330Notch signaling pathway - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
biocartacarm1pathwaytranscription regulation by methyltransferase of carm1
biocartacarmerpathwaycarm1 and regulation of the estrogen receptor
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartahuntingtonpathwayinhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors
biocartail7pathwayil-7 signal transduction
biocartanfatpathwaynfat and hypertrophy of the heart
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae
biocartapcafpathwaythe information processing pathway at the ifn beta enhancer
biocartapelp1pathwaypelp1 modulation of estrogen receptor activity
biocartapitx2pathwaymulti-step regulation of transcription by pitx2
biocartapmlpathwayregulation of transcriptional activity by pml
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartarelapathwayacetylation and deacetylation of rela in nucleus
biocartatgfbpathwaytgf beta signaling pathway
biocartawntpathwaywnt signaling pathway
reactomeR-HSA-1234158Regulation of gene expression by Hypoxia-inducible Factor
reactomeR-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygen
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1368082RORA activates gene expression
reactomeR-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expression
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-1592230Mitochondrial biogenesis
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-186712Regulation of beta-cell development
reactomeR-HSA-1912408Pre-NOTCH Transcription and Translation
reactomeR-HSA-1912408Pre-NOTCH Transcription and Translation
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201722Formation of the beta-catenin:TCF transactivating complex
reactomeR-HSA-210744Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
reactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates Transcription
reactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates Transcription
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2151201Transcriptional activation of mitochondrial biogenesis
reactomeR-HSA-2262749Cellular response to hypoxia
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2426168Activation of gene expression by SREBF (SREBP)
reactomeR-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in Cancer
reactomeR-HSA-2644603Signaling by NOTCH1 in Cancer
reactomeR-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain Mutants
reactomeR-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
reactomeR-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3134973LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
reactomeR-HSA-3214847HATs acetylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-3371568Attenuation phase
reactomeR-HSA-3371571HSF1-dependent transactivation
reactomeR-HSA-350054Notch-HLH transcription pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-3899300SUMOylation of transcription cofactors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactomeR-HSA-5619507Activation of HOX genes during differentiation
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5621575CD209 (DC-SIGN) signaling
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
reactomeR-HSA-8866907Activation of the TFAP2 (AP-2) family of transcription factors
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-8939246RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
reactomeR-HSA-8941856RUNX3 regulates NOTCH signaling
reactomeR-HSA-8941856RUNX3 regulates NOTCH signaling
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-8957322Metabolism of steroids
reactomeR-HSA-9006931Signaling by Nuclear Receptors
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9013508NOTCH3 Intracellular Domain Regulates Transcription
reactomeR-HSA-9013508NOTCH3 Intracellular Domain Regulates Transcription
reactomeR-HSA-9013694Signaling by NOTCH4
reactomeR-HSA-9013695NOTCH4 Intracellular Domain Regulates Transcription
reactomeR-HSA-9018519Estrogen-dependent gene expression
reactomeR-HSA-918233TRAF3-dependent IRF activation pathway
reactomeR-HSA-933541TRAF6 mediated IRF7 activation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD599Salermide1
iGMDRD579PF7503
iGMDRD144NSC953974
iGMDRD446LY 21832402
iGMDRD375GW-4058332
iGMDRD380Pifithrin-alpha3
iGMDRD480KU00606481
iGMDRD736UNC12151
iGMDRD138PX 128
iGMDRD8024-methylfasudil4
iGMDRD100Zebularine1
iGMDRD127Seliciclib1
iGMDRD887Compound 23 citrate3
iGMDRD692SB5908851
iGMDRD454JNK Inhibitor VIII1
iGMDRD268Cerulenin5
iGMDRD451Serdemetan3
iGMDRD630ML2033
iGMDRD84Lovastatin acid4
iGMDRD307Manumycin A8
iGMDRD148Pifithrin-mu9
iGMDRD424Tamatinib2
iGMDRD6044449-51-81
iGMDRD85Ursolic acid5
iGMDRD57Chloropentafluorobenzene1
iGMDRD211(1S,3R)-RSL31
iGMDRD177Teniposide4
iGMDRD132(-)-gallocatechin-3-O-gallate4
iGMDRD1016THZ-2-491
iGMDRD785XMD15-271
iGMDRD88AICA ribonucleotide1
iGMDRD733SGC09461
iGMDRD551Ponatinib1
iGMDRD267Oligomycin A2
iGMDRD3PD-1730741
iGMDRD246NPC262
iGMDRD556Quizartinib1
iGMDRD42Vorinostat2
iGMDRD433Lexibulin4
iGMDRD409Saracatinib1
iGMDRD889Compound 7d-cis8
iGMDRD476WH-4-0232
iGMDRD546BMS-7548072
iGMDRD403BAY 61-36061
iGMDRD483SCH-5290742
iGMDRD397Pazopanib1
iGMDRD639YK 4-2793
iGMDRD61Kinetin riboside3
iGMDRD748PHA-6657521
iGMDRD466Chaetocin2
iGMDRD1032VNLG/1241
iGMDRD247Blebbistatin3
iGMDRD568SCHEMBL150055121
iGMDRD260FQI-24
iGMDRD187BRD98765
iGMDRD730Kahalalide F1
iGMDRD23Gossypol2
iGMDRD719IOX21
iGMDRD79Gemcitabine2
iGMDRD775NCGC00346967-011
iGMDRD1018TL-1-851
iGMDRD698Neratinib2
iGMDRD219Bax channel blocker2
iGMDRD123Isoevodiamine5
iGMDRD1002rTRAIL1
iGMDRD672Alectinib1
iGMDRD103SN-386
iGMDRD158NSC1415406
iGMDRD202Curcumin3
iGMDRD5Tyrphostin AG 14782
iGMDRD455Idelalisib1
iGMDRD221Tamoxifen6
iGMDRD213SMR0000686506
iGMDRD77Itraconazole4
iGMDRD871BRD636810
iGMDRD662JQ-13
iGMDRD147Prima-16
iGMDRD552AZD-17753
iGMDRD112Methotrexate1
iGMDRD554CHEMBL14341373
iGMDRD54Phenformin1
iGMDRD1008SR-II-138A6
iGMDRD772BRD477011
iGMDRD239Dasatinib1
iGMDRD587CHEMBL5859511
iGMDRD632CP4667222
iGMDRD201SKI II5
iGMDRD696NG251
iGMDRD193Fqi17
iGMDRD673LSM-12151
iGMDRD634SCHEMBL26080411
iGMDRD255SB2250022
iGMDRD782DC-45-A23
iGMDRD885Compound 1102
iGMDRD759PFI-11
iGMDRD318PAC-12
iGMDRD332A-7700411
iGMDRD312Pelitinib1
iGMDRD577BIX012946
iGMDRD562Navitoclax2
iGMDRD690PRIMA-1MET9
iGMDRD60Quinoclamine10
iGMDRD607Ubistatin B5
iGMDRD345Compound 10b [PMID: 11504634]1
iGMDRD292NSC878771
iGMDRD351GW843682X2
iGMDRD499PDMP4
iGMDRD901ELCPK2
iGMDRD503CMK1
iGMDRD172T0913171
iGMDRD414MST-3123
iGMDRD872BRD71375
iGMDRD300Tozasertib4
iGMDRD505Pevonedistat2
iGMDRD353PD03259011
iGMDRD82Quiflapon10
iGMDRD126Tipifarnib5
iGMDRD151CHM-14
iGMDRD443Linifanib1
iGMDRD427ABT7373
iGMDRD779PRL-3 Inhibitor I3
iGMDRD135Lenalidomide1
iGMDRD513BML-2592
iGMDRD474Avrainvillamide6
iGMDRD8012,4-dideoxy-DC-45-A24
iGMDRD188Piperlongumine1
iGMDRD74Idarubicin2
iGMDRD399Selumetinib6
iGMDRD224Necrostatin-13
iGMDRD506Fedratinib5
iGMDRD369TGX-1152
iGMDRD64Parbendazole9
iGMDRD524ISX-96
iGMDRD532Olaparib4
iGMDRD523Cyanoquinoline, 114
iGMDRD945ML2143
iGMDRD251ML1625
iGMDRD289Parthenolide9
iGMDRD667BIX021892
iGMDRD286Nsc 6328394
iGMDRD329Merck606

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CREBBP

​​​​