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iGMDRD397

Canonical SMILES: CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N

InChI: InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)

InChI Key: CUIHSIWYWATEQL-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Pazopanib	CHEMBL1201733 CHEMBL477772	10114000	DB06589	Alone	Small Molecule

Drug Class:

Amides Angiogenesis Inhibitors Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Substrates Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak)Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak)Cytochrome P-450 Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Immunosuppressive Agents Kinase Inhibitor Moderate Risk QTc-Prolonging Agents P-glycoprotein/ABCB1 Substrates Protein Kinase Inhibitors QTc Prolonging Agents Receptors, Vascular Endothelial Growth Factor, antagonists & inhibitors Sulfones Sulfur Compounds UGT1A1 Inhibitors

Drug Targets:

FLT1 (P17948)KDR (P35968)FLT4 (P35916)PDGFRA (P16234)PDGFRB (P09619)KIT (P10721)FGFR3 (P22607)ITK (Q08881)FGF1 (P05230)SH2B3 (Q9UQQ2)VEGFR CSF1R

Drug Pathways:

RTK signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
2956	MSH6	1
8266	UBL4A	1
2475	MTOR	3
6598	SMARCB1	1
1387	CREBBP	1
5159	PDGFRB	1
25937	WWTR1	1
3091	HIF1A	1
2034	EPAS1	1
1665	DHX15	1
3688	ITGB1	1
7428	VHL	1
6850	SYK	2
54464	XRN1	1
92	ACVR2A	1
139285	AMER1	1
5834	PYGB	1
7157	TP53	1
3791	KDR	1
2263	FGFR2	2
4904	YBX1	1
57111	RAB25	1
4089	SMAD4	1
54658	UGT1A1	1
5290	PIK3CA	1
2113	ETS1	1
1869	E2F1	2
5925	RB1	1
7040	TGFB1	1
2261	FGFR3	1
4763	NF1	2

Gene in drug-gene network: Network Plot

Models in Pazopanib

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DATATYPES

CLASSFICATION

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