iGMDRD397
Canonical SMILES: CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
InChI: InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
InChI Key: CUIHSIWYWATEQL-UHFFFAOYSA-N
Loading, please wait...
Standard Name | CHEMBL | Pubchem CID | DRUGBANK ID | Drug Status | Drug Type |
|---|---|---|---|---|---|
Standard NamePazopanib CHEMBLCHEMBL1201733 CHEMBL477772 Pubchem CID10114000 DRUGBANK IDDB06589 Drug StatusAlone Drug TypeSmall Molecule | |||||
Drug Class:
AmidesAngiogenesis InhibitorsAntineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 SubstratesCytochrome P-450 CYP1A2 SubstratesCytochrome P-450 CYP2D6 InhibitorsCytochrome P-450 CYP2D6 Inhibitors (weak)Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (weak)Cytochrome P-450 Enzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 1-RingImmunosuppressive AgentsKinase InhibitorModerate Risk QTc-Prolonging AgentsP-glycoprotein/ABCB1 SubstratesProtein Kinase InhibitorsQTc Prolonging AgentsReceptors, Vascular Endothelial Growth Factor, antagonists & inhibitorsSulfonesSulfur CompoundsUGT1A1 InhibitorsDrug Targets:
FLT1 (P17948)KDR (P35968)FLT4 (P35916)PDGFRA (P16234)PDGFRB (P09619)KIT (P10721)FGFR3 (P22607)ITK (Q08881)FGF1 (P05230)SH2B3 (Q9UQQ2)VEGFRCSF1RDrug Pathways:
RTK signalingDrug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
Gene in drug-gene network: Network Plot
Models in Pazopanib
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.