E2F1


Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
E2F transcription factor 1MIM:189971Ensembl:ENSG00000101412HGNC:HGNC:3113PA15220q11.22

GO terms in E2F1


Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0000987proximal promoter sequence-specific DNA binding
MFICGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFIMPGO:0003677DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFTASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIEAGO:0019901protein kinase binding
MFIDAGO:0043565sequence-specific DNA binding
MFISSGO:0043565sequence-specific DNA binding
MFIEAGO:0046983protein dimerization activity
CCIDAGO:0000790nuclear chromatin
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005739mitochondrion
CCIDAGO:0005813centrosome
CCIDAGO:0032991protein-containing complex
CCIDAGO:0035189Rb-E2F complex
BPIMPGO:0000077DNA damage checkpoint
BPTASGO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0006351transcription, DNA-templated
BPIDAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BPIEAGO:0007283spermatogenesis
BPIMPGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIDAGO:0010628positive regulation of gene expression
BPIEAGO:0030900forebrain development
BPIDAGO:0043065positive regulation of apoptotic process
BPIEAGO:0043276anoikis
BPIDAGO:0043392negative regulation of DNA binding
BPISSGO:0045599negative regulation of fat cell differentiation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0048146positive regulation of fibroblast proliferation
BPIDAGO:0048255mRNA stabilization
BPTASGO:0070317negative regulation of G0 to G1 transition
BPISSGO:0070345negative regulation of fat cell proliferation
BPIEAGO:0071398cellular response to fatty acid
BPIEAGO:0071456cellular response to hypoxia
BPIEAGO:0071466cellular response to xenobiotic stimulus
BPIMPGO:0071930negative regulation of transcription involved in G1/S transition of mitotic cell cycle
BPIEAGO:0072332intrinsic apoptotic signaling pathway by p53 class mediator
BPTASGO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPIEAGO:1990086lens fiber cell apoptotic process
BPIEAGO:1990090cellular response to nerve growth factor stimulus
BPIMPGO:2000045regulation of G1/S transition of mitotic cell cycle

Gene expression in normal tissue: E2F1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in E2F1


DatabasePathway IDPathway Des.
biocartaarfpathwaytumor suppressor arf inhibits ribosomal biogenesis
biocartacellcyclepathwaycyclins and cell cycle regulation
biocartaetspathwaymets affect on macrophage differentiation
biocartafbw7pathwaycyclin e destruction pathway
biocartag1pathwaycell cycle: g1/s check point
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartap27pathwayregulation of p27 phosphorylation during cell cycle progression
biocartap53pathwayp53 signaling pathway
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartarbpathwayrb tumor suppressor/checkpoint signaling in response to dna damage
biocartaskp2e2fpathwaye2f1 destruction pathway
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111448Activation of NOXA and translocation to mitochondria
reactomeR-HSA-113501Inhibition of replication initiation of damaged DNA by RB1/E2F1
reactomeR-HSA-113510E2F mediated regulation of DNA replication
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-1362277Transcription of E2F targets under negative control by DREAM complex
reactomeR-HSA-1362277Transcription of E2F targets under negative control by DREAM complex
reactomeR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
reactomeR-HSA-139915Activation of PUMA and translocation to mitochondria
reactomeR-HSA-1538133G0 and Early G1
reactomeR-HSA-1538133G0 and Early G1
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1912408Pre-NOTCH Transcription and Translation
reactomeR-HSA-1912408Pre-NOTCH Transcription and Translation
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559585Oncogene Induced Senescence
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-539107Activation of E2F1 target genes at G1/S
reactomeR-HSA-539107Activation of E2F1 target genes at G1/S
reactomeR-HSA-6791312TP53 Regulates Transcription of Cell Cycle Genes
reactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
reactomeR-HSA-68689CDC6 association with the ORC:origin complex
reactomeR-HSA-68867Assembly of the pre-replicative complex
reactomeR-HSA-68874M/G1 Transition
reactomeR-HSA-68911G2 Phase
reactomeR-HSA-69002DNA Replication Pre-Initiation
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69205G1/S-Specific Transcription
reactomeR-HSA-69205G1/S-Specific Transcription
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953750Transcriptional Regulation by E2F6
reactomeR-HSA-8953897Cellular responses to external stimuli
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP1545miRNAs involved in DNA damage response
wikipathwaysWP179Cell Cycle
wikipathwaysWP1858Mitotic G1-G1-S phases
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP236Adipogenesis
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP2815Mammary gland development pathway - Involution (Stage 4 of 4)
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP3584MECP2 and Associated Rett Syndrome
wikipathwaysWP3804TP53 Regulates Transcription of Cell Cycle Genes
wikipathwaysWP3969H19 action Rb-E2F1 signaling and CDK-?-catenin activity
wikipathwaysWP3998Prader-Willi and Angelman Syndrome
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP707DNA Damage Response
pide2f_pathwayE2F transcription factor network
pidhes_heypathwayNotch-mediated HES/HEY network
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidp53downstreampathwayDirect p53 effectors
pidp75ntrpathwayp75(NTR)-mediated signaling
pidrb_1pathwayRegulation of retinoblastoma protein
pidtelomerasepathwayRegulation of Telomerase
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04137Mitophagy - animal - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD283Bosutinib1
iGMDRD781Sirolimus1
iGMDRD397Pazopanib2
iGMDRD546BMS-7548074
iGMDRD76Simvastatin1
iGMDRD222HC-0670471
iGMDRD151CHM-11
iGMDRD488KU-600191
iGMDRD639YK 4-2793
iGMDRD316N9-Isopropyl-olomoucine1
iGMDRD61Kinetin riboside3
iGMDRD107Valdecoxib1
iGMDRD285PYR-411
iGMDRD106Clofarabine1
iGMDRD117Docetaxel1
iGMDRD513BML-2592
iGMDRD874BRD89581
iGMDRD64Parbendazole3
iGMDRD888Compound 443
iGMDRD146Elesclomol1
iGMDRD188Piperlongumine1
iGMDRD399Selumetinib1
iGMDRD405PIK-753
iGMDRD1036X17AAG1
iGMDRD324CI-10401
iGMDRD123Isoevodiamine4
iGMDRD314Tanespimycin1
iGMDRD352PD-03259011
iGMDRD540Alisertib1
iGMDRD105Triptolide2
iGMDRD103SN-386
iGMDRD202Curcumin6
iGMDRD527GSK 10596151
iGMDRD329Merck601
iGMDRD366PI-1031
iGMDRD561ABT-2631
iGMDRD871BRD63683
iGMDRD489GSK-4613641
iGMDRD144NSC953973
iGMDRD599Salermide3
iGMDRD1008SR-II-138A6
iGMDRD634SCHEMBL26080413
iGMDRD280CYTOCHALASIN B3
iGMDRD608Refametinib1
iGMDRD261OSI-0271
iGMDRD557MGCD-2651
iGMDRD700AUY9221
iGMDRD298L-6854581
iGMDRD320PIK-931
iGMDRD1039X6816401
iGMDRD701NVP-AUY9223
iGMDRD160Cis-Platin1
iGMDRD410Ko-1431
iGMDRD262KU-559331
iGMDRD404PD3180881
iGMDRD177Teniposide3
iGMDRD450JNJ-268541651
iGMDRD351GW843682X3
iGMDRD85Ursolic acid3
iGMDRD459RO-33061
iGMDRD42Vorinostat3
iGMDRD82Quiflapon3
iGMDRD353PD03259012
iGMDRD505Pevonedistat3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in E2F1

​​​​